ID K3Z3I7_SETIT Unreviewed; 965 AA.
AC K3Z3I7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE RecName: Full=RING-type E3 ubiquitin transferase BRCA1 {ECO:0008006|Google:ProtNLM};
GN Name=101767419 {ECO:0000313|EnsemblPlants:KQL14789};
GN ORFNames=SETIT_3G183600v2 {ECO:0000313|EMBL:RCV17000.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQL14789, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EMBL:RCV17000.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL14789,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV17000.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV17000.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV17000.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL14789}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL14789};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AGNK02001606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003530; RCV17000.1; -; Genomic_DNA.
DR RefSeq; XP_004961548.1; XM_004961491.1.
DR AlphaFoldDB; K3Z3I7; -.
DR STRING; 4555.K3Z3I7; -.
DR EnsemblPlants; KQL14789; KQL14789; SETIT_021105mg.
DR GeneID; 101767419; -.
DR Gramene; KQL14789; KQL14789; SETIT_021105mg.
DR KEGG; sita:101767419; -.
DR eggNOG; KOG4362; Eukaryota.
DR HOGENOM; CLU_004218_0_0_1; -.
DR InParanoid; K3Z3I7; -.
DR OMA; PVCKVPY; -.
DR OrthoDB; 318045at2759; -.
DR Proteomes; UP000004995; Chromosome III.
DR GO; GO:0070531; C:BRCA1-A complex; IBA:GO_Central.
DR GO; GO:0031436; C:BRCA1-BARD1 complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0071480; P:cellular response to gamma radiation; IEA:EnsemblPlants.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0035067; P:negative regulation of histone acetylation; IBA:GO_Central.
DR GO; GO:0035066; P:positive regulation of histone acetylation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd17734; BRCT_Bard1_rpt1; 1.
DR CDD; cd15571; ePHD; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR13763:SF0; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 16..54
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 578..698
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 756..831
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 852..965
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 91..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..191
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 965 AA; 105919 MW; AC526DD243A69355 CRC64;
MADAGSLEKM GRELKCPICL SLLSSAVSIT CNHIFCNGCL MESMKSASSC PVCKVPFRRR
EIRPAPHMDN LVSVFKSMEV AAGTSIVATP LAPSPKVADG SQCGGNSGSK PKSSRKKKVA
SKKKNNTSKA AAASASCPTT KPSISMNKRI HVTLFPECET PTRPKKIMKP EEQKTKLNGD
AEEDKNKTLN SDRPESPSLS PFFWLRGEEQ EEGGTAGSLS EPLSLDTPLR HNAPTFSDIM
DSDDEIPNNV TPNSKAEVSE IFDSEIFEWS QRPCSPELRS TPLKKQGKLK KILDQITETD
DVEDMNLGGS FDKLDHESNA AQLVNGAEIK KRKSARARTK KNSKLPDCGK LCTKGCDAVH
QVTDIPVSIT TMPGQKNSGK KESNTSSGRS KVSCNSSRFL CSSDKSMETF PPQENSLEIE
ASENQLSERS HKNDKDSRRK LERTGNSALK TAENKSEQTS KRIRRISHGA VADEIRVISV
AENKTESPQH HTLIKGCTRH KHLDGRSKQS MESNIGPNTP SPLPGRCQFN EAIRTVPSVK
NFLVKNGSVK SIEQSDYSET IRSARNAVLQ KCEEKAPMAS CAFCQSDDIT EESGKMVHYH
NGKEVPAEFN GGTGVIHSHK NCLEWAPDVY FKDDSVFNLT TELARSRRIK CACCGIKGAA
LGCFDMSCRK SFHFTCAKLI PECRWDDENF VMLCPLHQSS KLPIETSESK KKSQRRLTPK
GSAQVRPCQV YGNKWTWPSG SPQKWVLCCS ALSPAEKGIV SEFAKIAGVP ISTSWNPSVT
HVIASTDLSG ACKRTLKFLM AILNGKWVVS IDWVKTCMEH MEPVDEVRFE VTTDVHGTRE
GPKLGRQRVI NKQPKLFASI HLYLHGDYTQ SYRGYLQDLV VAAGGTVLQR KPVSRDQQKL
LDDSSLILIV YSVENQDKGN PKSKDGVDTG RSQADAQALA CASGGKVVSS AWIIDSISAC
NLQPL
//
