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Database: UniProt
Entry: K3ZGZ6_SETIT
LinkDB: K3ZGZ6_SETIT
Original site: K3ZGZ6_SETIT 
ID   K3ZGZ6_SETIT            Unreviewed;      1105 AA.
AC   K3ZGZ6;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   03-JUL-2019, entry version 45.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   Name=101765223 {ECO:0000313|EnsemblPlants:KQK93909};
GN   ORFNames=SETIT_8G062200v2 {ECO:0000313|EMBL:RCV37432.1};
OS   Setaria italica (Foxtail millet) (Panicum italicum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae;
OC   PACMAD clade; Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX   NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQK93909};
RN   [1] {ECO:0000313|EMBL:RCV37432.1, ECO:0000313|EnsemblPlants:KQK93909, ECO:0000313|Proteomes:UP000004995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQK93909,
RC   ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC   {ECO:0000313|EMBL:RCV37432.1};
RX   PubMed=22580951; DOI=10.1038/nbt.2196;
RA   Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA   Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J.,
RA   Jenkins J., Barry K., Lindquist E., Hellsten U., Deshpande S.,
RA   Wang X., Wu X., Mitros T., Triplett J., Yang X., Ye C.Y.,
RA   Mauro-Herrera M., Wang L., Li P., Sharma M., Sharma R., Ronald P.C.,
RA   Panaud O., Kellogg E.A., Brutnell T.P., Doust A.N., Tuskan G.A.,
RA   Rokhsar D., Devos K.M.;
RT   "Reference genome sequence of the model plant Setaria.";
RL   Nat. Biotechnol. 30:555-561(2012).
RN   [2] {ECO:0000313|EMBL:RCV37432.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Yugu1 {ECO:0000313|EMBL:RCV37432.1};
RA   Noorani M.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblPlants:KQK93909}
RP   IDENTIFICATION.
RC   STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQK93909};
RG   EnsemblPlants;
RL   Submitted (AUG-2018) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; AGNK02004710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CM003535; RCV37432.1; -; Genomic_DNA.
DR   RefSeq; XP_004978893.1; XM_004978836.1.
DR   STRING; 4555.Si025848m; -.
DR   EnsemblPlants; KQK93909; KQK93909; SETIT_025848mg.
DR   GeneID; 101765223; -.
DR   Gramene; KQK93909; KQK93909; SETIT_025848mg.
DR   KEGG; sita:101765223; -.
DR   eggNOG; KOG0969; Eukaryota.
DR   eggNOG; COG0417; LUCA.
DR   KO; K02327; -.
DR   OMA; CLVNYTE; -.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000004995; Chromosome VIII.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004995};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      138    481       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      545    978       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1015   1086       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     50       Disordered. {ECO:0000256|MobiDB-lite:
FT                                K3ZGZ6}.
SQ   SEQUENCE   1105 AA;  123540 MW;  C14404BF849C8AA6 CRC64;
     MSSGGRGGKR RAPPPPAPSG AAAKRAHPNP GTPQPPPPAA AAAPGAEEED MMDEDVFLDE
     SILAEDEAAL LMIQRDEALA SRLARWKRPA LPADLATGCS RTVAFQQLEI DYVIGENHKE
     LLPNSSGPAA ILRIFGVTRE GHSICCQVHG FEPYFYIGCP SGMGPDDISR FHQTLEGRMK
     ESNRSSNVPR FVKRVELVQK QTIMHYQTQQ SQPFLKIVVA LPTMVASCRG ILERGITIEG
     LGSKSFLTYE SNILFALRFM IDCNIVGGNW IEVPAGKYRK AARVMSYCQL ELDCLYSDLV
     SHAAEGEYSK MAPFRILSFD IECAGRKGHF PEPTHDPVIQ IANLVTHQGE GQPFVRNVMT
     LKSCSPIVGV DVMSFDTERD ILLAWRDLIR EVDPDIIIGY NICKFDLPYL IERAEVLKIT
     EFPLLGRIRN SRVRVRDTTF SSRQYGVRES KDVTIEGRVQ FDLLQAMQRD YKLSSYSLNS
     VSAHFLGEQK EDVHHSIISD LQNGNSETRR RLAVYCLKDA YLPQRLLDKL MYIYNYVEMA
     RVTGVPISFL LSRGQSIKVL SQLLRKAKQK NLVIPNIKGQ GSGQDTFEGA TVLEARAGFY
     EKPIATLDFA SLYPSIMMAY NLCYCTLVPP EDARKLNLPP ESLNKTPSGE IFVKPELQKG
     ILPEILEELL AARKRAKADL KEAKDPLERA VLDGRQLALK ISANSVYGFT GATVGQLPCL
     EISSSVTSYG RQMIEHTKKL VEDKFTTVGG YEHNAEVIYG DTDSVMVQFG ASTVEDAMKL
     GREAADYISG TFTKPIKLEF EKVYFPYLLI SKKRYAGLYW TNPEKFDKMD AKGIETVRRD
     NCLLVKNLVT ECLHKILVDR DIPGAVQYVK NTISDLLMNR VDLSLLVITK GLTKTGEDYA
     VKAAHVELAE RMRKRDPATA PTVGDRVPYV IIKAAKGAKA YEKSEDPIYV LDNNIPIDPQ
     YYLENQISKP LLRIFEPILK NASKELLHGS HTRSVSISTP SNSGIMKFAK KQLTCLGCKA
     VISGASQTLC SHCKGREAEL YCKTVANVSD LEVLFGRLWT QCQECQGSLH QDVLCTSRDC
     PIFYRRRKAQ KDMAEARLQL DRWDF
//
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