ID K3ZQ64_SETIT Unreviewed; 1129 AA.
AC K3ZQ64;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN Name=101752499 {ECO:0000313|EnsemblPlants:KQL22643};
GN ORFNames=SETIT_2G051700v2 {ECO:0000313|EMBL:RCV09719.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQL22643, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EMBL:RCV09719.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL22643,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV09719.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV09719.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV09719.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL22643}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL22643};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; AGNK02000700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003529; RCV09719.1; -; Genomic_DNA.
DR RefSeq; XP_004955617.1; XM_004955560.3.
DR AlphaFoldDB; K3ZQ64; -.
DR STRING; 4555.K3ZQ64; -.
DR EnsemblPlants; KQL22643; KQL22643; SETIT_028744mg.
DR GeneID; 101752499; -.
DR Gramene; KQL22643; KQL22643; SETIT_028744mg.
DR KEGG; sita:101752499; -.
DR eggNOG; KOG1967; Eukaryota.
DR HOGENOM; CLU_005943_0_0_1; -.
DR InParanoid; K3ZQ64; -.
DR OMA; FSFMPEF; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000004995; Chromosome II.
DR GO; GO:0097361; C:CIA complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 48..316
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 710..1083
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1129 AA; 125586 MW; B1801D6424852B62 CRC64;
MARVLPGEWV PHVEAYVDVS RPAAQHSASV DALAALVNKD KLTLFDLVSK MEMYLTTTDH
IVRSRGILLL GEILSRISVK WLDVNTITTL SDFFISRLSD WQAIRGALVG CLALLHRKQG
VGCIVIADVK RIVESFLQNV QVQSLAAADR KLCFQILSCI LDRYPEVVKT MDGEQLYWIC
EAIDEEKDPE CLKLSFHVVE VVMKLFPDPS GLAAQFASEF FEILSKYFPV YFTHGVGDDL
NATRDDLSRA LMHAFCSTPY FEPFAIPLLL DKLSSSLPLA KIESLKYLDN CIRFYGTDRM
VRHASAVWFK LKEVIFSSSP EEFLLTSGSP KDAEKNKNQM VLEALKCLKT AIMCIDSSDK
DLFINLILLD EDIVNKIHSI SSEEKSILSS LEDLAQLHAL GSVISILSES STYLCTRVLQ
EHFTQLVDIL GTSTDYESRQ LNTCNGSSSA ADNYGALYLS VQMLTSCREV ALVSYADCSS
IKLAKESWWL ILEKKLDRLI HFLGSFLTID SESMQSMFRQ EYVSCAVKGL LTLATFPEQC
SPLTANAYED ILAMLTSVII SKFENVDLWR LSLKALTSIG SSIGEFHASQ KEVIYCQTVV
DKIVSLVESY DGPMPLSLRL EASYEIGTAG FNYMLRVARS LEGAVVTNIS KTNGGMECTE
HVAHLFECYS GQVLPWLFTS GGINELALSF AMHLLDEIKD LTMLDRIGSQ GLLDSLMAGM
KLLVGVCTEE QQTRIVQKAY SMVSSVIPLP LKSMAYHLLS ADELVPSHTV QETALVGMLS
SVIVGLRPQT PAPDMVVMIN LFTVFLLNGK LPAAYALASV FNKYLHNPEF SHENQLDKIL
DGILERCFST VLASNQSKIS QSGNVLSKID ILSGLAWIGK GLLMRGDEKV KDISMFLLKC
LCSDETLATI PSHEEESYVN DSSNTSIATS AAGAFHVMMS DSEVCLNKKF HARIKPLYKQ
RFFSIMMPIF LSKIKEATSM TTKLALYRAF GHIISNAPVP AVITEAHQIL LVMVDSLAKL
SVDIQDKDLV YNLLLVLSGM LMDEKGKECI LDNVHITISV LTQLVSYPHM MVVRETALQC
LVAFSTFPHS KVFPMRRKVL QAAIKALDDK KRAVRQEAVR CRQTWQSFA
//
