ID   K3ZQR0_SETIT            Unreviewed;       824 AA.
AC   K3ZQR0;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775};
GN   Name=101752649 {ECO:0000313|EnsemblPlants:KQL27296};
GN   ORFNames=SETIT_2G442900v2 {ECO:0000313|EMBL:RCV14661.1};
OS   Setaria italica (Foxtail millet) (Panicum italicum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC   Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX   NCBI_TaxID=4555 {ECO:0000313|EMBL:RCV14661.1};
RN   [1] {ECO:0000313|EMBL:RCV14661.1, ECO:0000313|Proteomes:UP000004995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL27296,
RC   ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC   {ECO:0000313|EMBL:RCV14661.1};
RX   PubMed=22580951; DOI=10.1038/nbt.2196;
RA   Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA   Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA   Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA   Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA   Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA   Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT   "Reference genome sequence of the model plant Setaria.";
RL   Nat. Biotechnol. 30:555-561(2012).
RN   [2] {ECO:0000313|EMBL:RCV14661.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Yugu1 {ECO:0000313|EMBL:RCV14661.1};
RA   Noorani M.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblPlants:KQL27296}
RP   IDENTIFICATION.
RC   STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL27296};
RG   EnsemblPlants;
RL   Submitted (AUG-2018) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   EMBL; AGNK02001383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CM003529; RCV14661.1; -; Genomic_DNA.
DR   RefSeq; XP_004958798.1; XM_004958741.2.
DR   AlphaFoldDB; K3ZQR0; -.
DR   STRING; 4555.K3ZQR0; -.
DR   EnsemblPlants; KQL27296; KQL27296; SETIT_028940mg.
DR   GeneID; 101752649; -.
DR   Gramene; KQL27296; KQL27296; SETIT_028940mg.
DR   KEGG; sita:101752649; -.
DR   eggNOG; KOG1096; Eukaryota.
DR   HOGENOM; CLU_003782_3_0_1; -.
DR   InParanoid; K3ZQR0; -.
DR   OMA; MICECLD; -.
DR   OrthoDB; 20951at2759; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000004995; Chromosome II.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003876; F:AMP deaminase activity; IBA:GO_Central.
DR   GO; GO:0046033; P:AMP metabolic process; IBA:GO_Central.
DR   GO; GO:0006188; P:IMP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF10; AMP DEAMINASE-RELATED; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000004995}.
FT   REGION          49..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        69..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   824 AA;  95019 MW;  5067342387A9A7D6 CRC64;
     MDSPYALHLA VAALVGASFA AASAYYMHRK TLDQLLRFAR SLDRDQRRRT RLLPDGEAHD
     YDLEDAEEDQ DHTPAHRDHD RRTMPIPPGL PPLHTGREGR PVISPGSTKR VGAIVRPTTP
     KSPVPSVSAF ERIEDSDEEE DLVPDAKNDA AYLASNGAVA SELLPDKTSQ NGELKAVPST
     QMIRSHSATG SLHVPQLNPI AADILRKEPE HETFSKINIT AVETPSSDEI EAYKVLQKCL
     ELRERYIFRE EVAPWEKEII TDPSTPKPNP NPFNYEHQAK TEHHFEMVDG VVHVYPNKDS
     KERLYPVADA TTFFTDMHYI LRVLAAGDIR TVCHHRLNLL EQKFNLHLMV NADRELLAQK
     AAPHRDFYNV RKVDTHVHHS ACMNQKHLLR FIKSKLRKEP DEVVIFRDGT YLTLKEVFES
     LDLTGYDLNV DLLDVHADKS TFHRFDKFNL KYNPCGQSRL REIFLKQDNL IQGRFLAELT
     KEVFSDLEAS KYQMAEYRIS IYGRKKSEWD QMASWIVNNE LYSENVVWLI QIPRIYNIYR
     EMGTINSFQN LLDNIFLPLY EVTIDPASHP QLHVFLEQVV GLDLVDDESK PERRPTKHMP
     TPEQWTNVFN PAYAYYVYYC YANLYTLNKL RESKGMTTIK LRPHCGEAGD IDHLAAAFLT
     SHNIAHGVNL RKSPVLQYLY YLAQIGLAMS PLSNNSLFID YHRNPFPTFF LRGLNVSLST
     DDPLQIHLTK EPLVEEYSIA ASLWKLSSCD LCEIARNSVY QSGFSHRLKS HWIGRNYYRR
     GPEGNDIHQT NVPHIRVEFR HTIWKEEMEL IHLRNVKLPE EIDR
//