ID K4A4M0_SETIT Unreviewed; 5181 AA.
AC K4A4M0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQK88856, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EnsemblPlants:KQK88856, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQK88856,
RC ECO:0000313|Proteomes:UP000004995};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EnsemblPlants:KQK88856}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQK88856};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; AGNK02005579; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 4555.K4A4M0; -.
DR EnsemblPlants; KQK88856; KQK88856; SETIT_033824mg.
DR Gramene; KQK88856; KQK88856; SETIT_033824mg.
DR eggNOG; KOG1808; Eukaryota.
DR HOGENOM; CLU_000050_0_2_1; -.
DR InParanoid; K4A4M0; -.
DR OMA; ILEQWHR; -.
DR Proteomes; UP000004995; Chromosome IX.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 7.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 2.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 6.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995}.
FT DOMAIN 4968..5169
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 4319..4356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4413..4777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4790..4823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4426..4442
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4453..4498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4499..4529
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4530..4559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4560..4579
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4580..4631
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4632..4713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4720..4754
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4756..4777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4790..4807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4809..4823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5181 AA; 586567 MW; A02D97119BB69328 CRC64;
MSLDGSFSTA EALARLLARC PALRSDPRLD ALASSTDAAP PARDDVTAAF AEPLLHPNYS
VPVLGCFLPL APALVDRAVA LLRAAGPLAL RADDASRLEE EAGEGDVRVV EFYLSRGRGL
RLHELACLAL ARALDIAPYL LGSVLSYFKF SPPPFQRLRA SFPSQIGSKE LHLFLDATRV
SYRFLQLEPS VFCEQWDWSC FLDLVYSTAD YSLVDNSLNS VGLNLRWCTI QILMIVLKAS
DMGIESFGLR ADEAFRCFLR WKKYCMDTSL EKASLYLQNE DGNSKSSVDG LTTLADCLSN
WPEIATGRDR SVGIYECPFV LTATLRKSYE VALMAVSQKW PVLLYGPVGA GKTALINKLA
QMGGNRGIYI HAIVKGLWIV FEDIDKAPND VQSILLPLLE GSSAFSVGHA EAVEVAESFR
LFATITTSQS DVSHALEDTF EKVNSLGSYQ FGGPNIAGGL SDGVLHRFSL RDLLKWCKRI
LGVDLNFEGL GFAFSCCKLI YQEALIQKGP FADIRRALEV LERVACSIKF NEPVLLVGET
GTGKTTIVQN LAAWLKQPLT VLNLSQQSDI SDLLGGFKPT DARSICFPLY IEFKDLFCQS
FPAKDNEAIL RHCDVYVMEK NWKKLLHTLV KCAEKAQKLI EGISKSSSGS KRKRSLPAQV
VSDWDTFSSR LNAACQQIGS ATGMSFQFVE GAFVSALRNG HWILLDEVNL APPETLQRIG
AVLDGEKGTL CLAERGDVDY VERHPCFRMF ACMNPATDAG KRDLPYTFRS RFTEYFVDDL
MDDDDLRLFV TKYLDGLNVA NGVIDGIVRF YKVAKKESEE RLQDGANQKP QFSLRSLSRA
LGYIKSAEKR FGFRKALYDG FCMFFLTMLD APSAKIIKNL IVSLLLDGKV PPSICFADYF
IEKPMQLDGC ESDEFLQSYV LTNSVTEHIV NLARAVYIKR FPVLLQGPTS SGKTSLVRYL
AAKTGHEFVR INNHEHTDLQ EYLGTYVTDS QGKLQFQEGA LVKAVREGHW IVLDELNLAP
SDVLEALNRL LDDNRELFVP ELQETIPAHP NFMLFATQNP PMLYGGRKML SRAFRNRFIE
VHVDEIPEDE LVTILEQRSR IAPSYAKKMV EVMKDLQRHR QNSRVFAGKH GFITPRDLFR
WANRYRTFEG KSYEDLAKDG YLLLAERLRD DNEKAVVQEA LERQLRVKLN IADLYNSEVT
REDHLSLDAI RQRVEECFGN ITWTKSMWRL YFLIERCYRS REPVLLVGET GGGKTTVCQV
LSAVLGSRLH ILNCHQYTET SDFIGGFCPI RDRSTIALEF KHLVAKIKQM KIFVYVAGDM
PLETDISGAD SVMSHLNEIL DRYRKGKDLF PEVSAQDLDT MEQIKLDLMH LKKRWQAIFL
WQDGPLVQAM KNGDLFLIDE VSLADDSVLE RLNSVLEPER KLSLAEKGGS VLEKISAHPN
FFILATMNPG GDYGKKELSP ALRNRFTELW VPAVTDVDEL KSITLGRFTK AELSCFGDCI
VNFWKWFNQL HIGRTLTIRD LLSWISFINV TEQNLGPKQA LIHGLFLILL DGLSLGVNVS
KSEATEMRST CLSFLLEELQ KVEGKAVDSY LSDLNYYGWG DNMRKADTDH DHLEGHFGIS
PFYIPKGHFA CKQQGFEIMA PTTSKNVLRV LRGMQLSKPL LLEGSPGVGK TSLIVALAGL
SGHDVVRINL SEQTDMMDLL GSDLPAEGEN GMEFSWSDGI LLQALKNGSW VLLDELNLAP
QSVLEGLNAI LDHRAEVFIP ELGRTYKCPP SFRIFACQNP SSQGGGRKGL PKSFLNRFTK
VYVDELSEED YLFICKSRYP LISESFLRNL ICFNNRLYMD TMVHRKYGQQ GSPWEFNLRD
IIRSCEMVAG SPDTSKDDCF LNTVYLQRMR TVVDRHKVIE LFEEVFERKP SIHQSKMLCV
NPHCLVVGNA SIRRNNFQSY KVRNNQLNIF PGTLNSLEAA MHCIHQELLG CFEQYNFFRH
YKAVISQVEH YVDVYFSLSM DLNWKNLVVE RKGLFTKWFE FVAAKKYSSV RTSTLVEMSG
DASLPSLSLI AEIIEQMKCD LEMFDLPISL TKDDLLKTLK SIYKLQQNGT AHQPVKFEWV
AGDLIRAIEC GEWIVLDNAN FCNPTVLDRI NSLVEQERSI VVNECGLVDG NPVIIKAHPK
FRMFLTVNAN YGEVSRAMRN RGVEIFLMDQ RWDLKGSNVP ENSERKDVIR FLISSGIPRM
ELISSMSKAH MYAKAEGLSV GINITLLEIT RWVQLFQQLI IKGNRFLWSL HLSWEHTYLP
SLGEVYGSKI VEAGKNMFLI DFDGYSTSLN SGFSLTLPGG WPSEQTLRDF IWYSKETCVN
RNCMYLQSLS AQYAAYQIYN LKESSPLLVP VGNMHPYIIP TTSLRELQFP TVSGQSVDTL
VTGEFDSDLA DQMLFFAANW VMEQSTEHDL ELYTVWFEWY NDLFQPYCNF FENYLHIRKQ
ESEHPIWHCI LECYREIVAY HKTNIVSQPI PPLSKKLLDM AGCGALKAFQ DRLCNAFNGL
RLLRLTLQQW QFETKFPDLA LPKSTLLPAL KSLRRLEGEV LKRIVKSQEL LRIYSRILDY
HRSIWKMMIS SQFEALPVVW NLLRKEILKL QPKFPEEIGL FLMESVNLNN LHDFNFQYGE
PTLWIYGGHP LVPSSSMVFD GIQAIVAFSA DVWPKKNLLN MHLDDKQQLA DTMLSANHDL
RRLAVEGISM AIVATKTEED ISTIVGRLDD VHQRLRGTVD FERSKLLSKT SVPEVNFCCS
VSSDILCNIY GFNGWLASLS LLNLKSINLD TLLLKRLSKC AQKDPSEAHE IIVNSGYLLT
YAKNYSLGSS SRSPLEYTQH QIIWWICDAW ATVDNVHVEL ANSILEMWYN YHSSLWTYCS
GSPKSLSVTH DETCDLAHLT KMDAINTLIQ QDLRVVDYQK NCFMLKISSG NLWEGVSFMG
NLVASLHSVA DSLFKQIIFA HKKHFKEENF NRLEAVLFQQ LKHDIEKEDL DTICALLSSS
SHGVLASLAG SDELVESLLM DLYSSYSHDS LLHTGAAWMH IGELRFRILL SSYIPDPAFE
SSYIHSHILE KISLVKLEGK VRHDCEELAG SSSPEDSHDY KLLQDLETEE RDIRAKVVFR
PQKSKHKSLV AACFEFENRL SDCKDLLANL KCKGAGQLEV DRVCNWQITS MNFIKRLTEE
YGEYIDLIQP IQVAVYEMKL GLAIALSGSL QREYLKKIKE DDIERVLGTV CAFMQFPSVS
DLTEYAVDDK LRSQYNGSGN VDVLKKLAAV SSQLNVGKVG DKVKSHSEML VSIHHMLLVR
TTYRISCSLI MDTPSYLLLK NTFDHFTNLW IGMKSHLKAK ENDDSQYYKF KSRMISIEEI
FNEDVPLLSD MDVEGDFVPD NEEKLEQAFF KILVAYTPYM PVLISGCLFH FAYLCRNLIL
FQQRIDNGVV EDSWDAIPDS VLKCIVMIHN QLFGSPDLFE QPSKCQISDA QKIQSFIESY
ELGTRILKDL PELTCSMFDE KLMPEHLFRV CLEYQRTSAT SLNCSGYNAY KDPNPFVMFK
MVEPLTTLKK EVTNYLNEWP DHPGLLKILD TIASLLAMPL STSISKALLG LQLLAVKVQT
LQENDSKFFL KGHLPPIFML VYSWQRLELD CWPLLLEELQ EKYDMDAAKL WFPLRALLTQ
TSGISTDEDL SIIKSVEEFV QTSNLGEFKR RLHLLLAFHG EISEGASMGD YSSTAMKKIR
NILYNVFGYY MQFLSLVDGH IGSGKGDIEK ELKDLVKLYS WEQAPYSTAS IESFKRTRQK
IFKLLQQFNK ILRKPVIDLL NEVTARKVPC WLDPHLPESQ FPVDTENFNK RFLWYSKWAS
ETSLSLQALQ NTNGTTVGIP TVKEYSDTVQ NVNHRLDEIE LNDRLKFFWD ALERICGSAN
FANTLKHGKK NQKKTALSNL FKTLEECGLS KHRSMGHEWR DELSAPSSLF LEESYDAAHL
LQQVSSQKKL EDVSIVHSML LTTDNWKYAN CQYFKCLAMM QQLRQVSLKF NKDLGLEEKL
FDSVLNMTTD TNLLLTSFKD CHHSSCGNSK EAAAMSTLLE KFLSRFSESK DLLDKYLLGS
NNIFTGAHKN VPLATREMEE LLPLATREME EHFYENCQLV DSLREDMQVM RQQEISMRSV
KEVLISRLEE LLDKGKMAIE NPREVEDDHK ICSDILPELE GSYEGILKET FMLAVGVLGK
LTDFEICNNG AEDSPVGTIT SWKDVLQSYT VNLKLNHICD ASEKLCITVK RLVDCKPEIR
SNIEVHLMHL HAWLGVILSS AEGILSELLE AHRTTAEITH ALGDLFIYLF VEGFGSTEDT
TEAADDEQQQ DAVETGTGLG DGDGGKSVSS KIEDPSEIED KATVSVSKYI LLTVTVSVCF
IAANIPDVEQ DATHKPDQAP KNDNEAVEMK EDFDADLSDV SEDPEGKESG TEDEDEDMNL
DSQMGDTGDS SEVVGKKSWD KDEDDDPKTS TEKYDSSSSV RAEKNDRELR AKDDGSVEEE
DHMEMDNDDE QGKNDDLEDE PITCEETDLN TEEVMDKTDA YDDRTGPELP EPDNDSHDID
METQELDEED ADNEDIGSEE VEQADQRSDA SDDMELGDMA QHGDSAVDHD GDHVEDANTE
NIDKQQLDKI DSLKHPSQGQ PENMQVDNNR ESEANLANSS DMNGAVAPSV NFSGNELPNM
EISMPNSGDD SRLSNTKPEM QNDAPQSHIK QANPFRSIGD AMEEWKERAR VSADTQDNPP
ENGHHSDDEN ATQFRYVPEG EQSTSQALGA ATADQISDDT QIKQSFIEDE SRVKQLEQSE
ERTPDNPEVP HIQASQALTS KSENANVLEG PEIQTDTSVQ DLVEVGKDNS FQNLVSFKRP
PADDKIALDD LAVDTELSTQ MDLDIPDAET KRAFVDWKNL ELATMKLSQE LAEQLRLVME
PTLASKLQGD YRTGKRINMK KVIPYIASHF RRDKIWLRRT KPNKRNYQVV IAIDDSRSMS
EGKCGKVAIE ALVTVCRAMS QLEVGQFAVA SFGKKGNVRV LHDFHQIFNS EAGVKMISSL
SFEQDNKIED QPVSDLLTHL NTMLDTAVAR ARTPSGQNPL QQLILIISDG KFHEKENLRR
HVRDVLNRKR MVAYVLLDSP EDSIMNLQEA CFKAGENLQL KKYMDSFPFP YYVMLQNIEA
LPRTLADLLR QWFELMQSAN E
//
