ID K4A5C6_SETIT Unreviewed; 989 AA.
AC K4A5C6;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=5'-3' exoribonuclease {ECO:0000256|PIRNR:PIRNR037239};
DE EC=3.1.13.- {ECO:0000256|PIRNR:PIRNR037239};
GN Name=101776459 {ECO:0000313|EnsemblPlants:KQK86694};
GN ORFNames=SETIT_9G057500v2 {ECO:0000313|EMBL:RCV40482.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQK86694, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EMBL:RCV40482.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQK86694,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV40482.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV40482.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV40482.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK86694}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQK86694};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- FUNCTION: Possesses 5'->3' exoribonuclease activity. Acts as an
CC endogenous post-transcriptional gene silencing (PTGS) suppressor.
CC {ECO:0000256|PIRNR:PIRNR037239}.
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1
CC subfamily. {ECO:0000256|ARBA:ARBA00006994,
CC ECO:0000256|PIRNR:PIRNR037239}.
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DR EMBL; AGNK02005326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003536; RCV40482.1; -; Genomic_DNA.
DR RefSeq; XP_004981452.1; XM_004981395.2.
DR AlphaFoldDB; K4A5C6; -.
DR STRING; 4555.K4A5C6; -.
DR EnsemblPlants; KQK86694; KQK86694; SETIT_034080mg.
DR GeneID; 101776459; -.
DR Gramene; KQK86694; KQK86694; SETIT_034080mg.
DR eggNOG; KOG2044; Eukaryota.
DR HOGENOM; CLU_006038_1_0_1; -.
DR InParanoid; K4A5C6; -.
DR OMA; AFLYQMC; -.
DR OrthoDB; 167745at2759; -.
DR Proteomes; UP000004995; Chromosome IX.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-UniRule.
DR GO; GO:0000956; P:nuclear-transcribed mRNA catabolic process; IBA:GO_Central.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR017151; Xrn2/3/4.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR12341:SF74; 5'-3' EXORIBONUCLEASE 4; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF17846; XRN_M; 2.
DR Pfam; PF03159; XRN_N; 1.
DR Pfam; PF00098; zf-CCHC; 1.
DR PIRSF; PIRSF037239; Exonuclease_Xrn2; 2.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|PIRNR:PIRNR037239};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR037239};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|PIRNR:PIRNR037239};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|PIRNR:PIRNR037239};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT DOMAIN 264..279
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT REGION 780..819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..989
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..964
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 989 AA; 112731 MW; 3CC927B9EE4A9671 CRC64;
MGVPAFYRWL ADRYPLTVSD AEEEEPVELE PGAFVPVDLR RPNPNGIEFD NLYLDMNGII
HPCFHPEGRP APTTYDEVFK SIFDYIDHLF GLVRPRKLLY MAIDGVAPRA KMNQQRSRRF
RAAKDAADAA AEEERLRKEF EAEGRTLAQK EKSEAIDSNV ITPGTQFMFV LSTALQYYIQ
LRLNHTLGWQ SVKVILSDSN VPGEGEHKIM SYIRLQRNLP GFDPNTRHCL YGLDADLIML
ALATHEVHFS ILREVISMPG QQEKCFLCGQ VGHLAAECRG PSQVDSAVEL PPIHKKKYQF
LHIWVLREYL AKDLEIVDAP FKINFERLID DFVFMCFFVG NDFLPHMPTL EIREGAINLL
MSIYRAEFIS MGGYLTDGGE VVLDRVEHFI QSVAFNEEQI FQKRARIQQA RENNEERNKI
QRESTEENQY VDKVKLGEPG YRERYYAEKF KEEAESKPID QVRRDVVQKY VEGLCWVMRY
YYQGVCSWQW FYPYHYAPFA SDLKDLAELE ITFFLGQPFK PFDQLMGTLP AASSNALPKY
YGDLMTDPNS PLKSFYPKDF EIDMNGKRFA WQGVAKLPFI DETRLLAETR KLEDTLTEEE
KFRNTTMFDI IYVRETHPLT AQIAFLYRMY NHLPRTDPYV IPIDPAASGG MNGFLCLSER
NWYSITVTSP VKCFNGIAQN RVLNATYLNP QYHKHIPEPP VGVIVPGKIL KPSDFKPFPV
LWHEDNSRRQ ARERPQVSGA LSGSLLGQAA HRLVKNSLQI KSGSAAGLLE MPYRGAPYGP
GNRPRPAGPL GYERGFVDNP HHAHTSRSVP NSHPQFFGDA QANRQPMRIL ERPNSGSHEA
GIHASMSKLT IHEGPRLHQN NRMQNSGYWP NQPHPNHYAG PPPQQPMQNI SFTPQRPFQT
GGFPQQRPVN GVPPPLPPSN WIGKQPTGGP PGVPAKHDPR TAPDRQLKQD NPRSQQDKRQ
QATKVYRVKT QATNGNGLSE SGKQEEPAA
//
