ID K4A904_SETIT Unreviewed; 494 AA.
AC K4A904;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=3-ketoacyl-CoA synthase {ECO:0000256|PIRNR:PIRNR036417};
DE EC=2.3.1.- {ECO:0000256|PIRNR:PIRNR036417};
GN Name=101761757 {ECO:0000313|EnsemblPlants:KQK91917};
GN ORFNames=SETIT_9G487500v2 {ECO:0000313|EMBL:RCV45863.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQK91917, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EMBL:RCV45863.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQK91917,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV45863.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV45863.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV45863.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK91917}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQK91917};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|PIRNR:PIRNR036417}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|PIRNR:PIRNR036417}.
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DR EMBL; AGNK02006082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003536; RCV45863.1; -; Genomic_DNA.
DR RefSeq; XP_004985167.1; XM_004985110.3.
DR AlphaFoldDB; K4A904; -.
DR STRING; 4555.K4A904; -.
DR EnsemblPlants; KQK91917; KQK91917; SETIT_035360mg.
DR GeneID; 101761757; -.
DR Gramene; KQK91917; KQK91917; SETIT_035360mg.
DR KEGG; sita:101761757; -.
DR eggNOG; ENOG502QPKZ; Eukaryota.
DR HOGENOM; CLU_013238_2_2_1; -.
DR InParanoid; K4A904; -.
DR OMA; WYELNFI; -.
DR OrthoDB; 930987at2759; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000004995; Chromosome IX.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR012392; 3-ktacl-CoA_syn.
DR InterPro; IPR013747; ACP_syn_III_C.
DR InterPro; IPR013601; FAE1_typ3_polyketide_synth.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR31561; 3-KETOACYL-COA SYNTHASE; 1.
DR PANTHER; PTHR31561:SF5; 3-KETOACYL-COA SYNTHASE 5-RELATED; 1.
DR Pfam; PF08541; ACP_syn_III_C; 1.
DR Pfam; PF08392; FAE1_CUT1_RppA; 1.
DR PIRSF; PIRSF036417; 3-ktacl-CoA_syn; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|PIRNR:PIRNR036417};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Transferase {ECO:0000256|PIRNR:PIRNR036417};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..367
FT /note="FAE"
FT /evidence="ECO:0000259|Pfam:PF08392"
FT DOMAIN 384..464
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08541"
FT ACT_SITE 222
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 301
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 385
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 389
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 418
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 422
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
SQ SEQUENCE 494 AA; 55573 MW; A0DDA167B55966DE CRC64;
MPGGGVFSGS VNLKYVKLGY QYLVNHFLTL LLVPVMAATA LELARLGPGE LLTLWRSLEL
DLVHILCSAF LVVFVGTVYV MSRPRPVYLV DYSCYKPPAS CRVPFATFME HTRLISDDEK
SVRFQTRILE RSGLGEDTCL PPANHYIPPN PSMEASRAEA QLVIFSAIDD LVRRTGLKPK
DIDILVVNCS LFSPTPSLSA MIINKYKLRS NIRSFNLSGM GCSAGLISID LARDMLQVHP
NSNALVVSTE IITPNFYQGT RRDMLLPNCL FRMGAAAILL SNRRREARRA KYRLVHVVRT
HKGADDRAYR CVYQEEDDQG FSGISLSKEL MAIAGDALKS NITTIGPLVL PMSEQLLFFF
RLVGRKLINK KWKPYIPDFK LAFEHFCIHA GGRAVIDELQ KNLQLSARHV EASRMTLHRF
GNTSSSSLWY ELAYIEAKGR MRRGDRVWQI GFGSGFKCNS AVWKCLRSIK TPTNGPWDDC
IDRYPVDIPE VVKL
//
