ID K4ACM3_SETIT Unreviewed; 324 AA.
AC K4ACM3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Translocase of chloroplast {ECO:0000256|PIRNR:PIRNR038134};
DE EC=3.6.5.- {ECO:0000256|PIRNR:PIRNR038134};
GN Name=101784033 {ECO:0000313|EnsemblPlants:KQK91748};
GN ORFNames=SETIT_9G474200v2 {ECO:0000313|EMBL:RCV45699.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQK91748, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EMBL:RCV45699.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQK91748,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV45699.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV45699.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV45699.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK91748}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQK91748};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- FUNCTION: GTPase involved in protein precursor import into
CC chloroplasts. Seems to recognize chloroplast-destined precursor
CC proteins and regulate their presentation to the translocation channel
CC through GTP hydrolysis. {ECO:0000256|PIRNR:PIRNR038134}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR038134}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast outer membrane
CC {ECO:0000256|PIRNR:PIRNR038134}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC TOC34 subfamily. {ECO:0000256|PIRNR:PIRNR038134}.
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DR EMBL; AGNK02006061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003536; RCV45699.1; -; Genomic_DNA.
DR RefSeq; XP_004985054.1; XM_004984997.3.
DR AlphaFoldDB; K4ACM3; -.
DR STRING; 4555.K4ACM3; -.
DR EnsemblPlants; KQK91748; KQK91748; SETIT_036630mg.
DR GeneID; 101784033; -.
DR Gramene; KQK91748; KQK91748; SETIT_036630mg.
DR KEGG; sita:101784033; -.
DR eggNOG; ENOG502QSV2; Eukaryota.
DR HOGENOM; CLU_051932_0_0_1; -.
DR InParanoid; K4ACM3; -.
DR OMA; QRGKLWI; -.
DR OrthoDB; 597322at2759; -.
DR Proteomes; UP000004995; Chromosome IX.
DR GO; GO:0009707; C:chloroplast outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0015450; F:protein-transporting ATPase activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR CDD; cd01853; Toc34_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR045058; GIMA/IAN/Toc.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005688; Toc34.
DR NCBIfam; TIGR00991; 3a0901s02IAP34; 1.
DR PANTHER; PTHR10903; GTPASE, IMAP FAMILY MEMBER-RELATED; 1.
DR PANTHER; PTHR10903:SF149; TRANSLOCASE OF CHLOROPLAST 33, CHLOROPLASTIC; 1.
DR Pfam; PF04548; AIG1; 1.
DR PIRSF; PIRSF038134; Toc34; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51720; G_AIG1; 1.
PE 3: Inferred from homology;
KW Chloroplast {ECO:0000256|PIRNR:PIRNR038134};
KW GTP-binding {ECO:0000256|PIRNR:PIRNR038134};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR038134};
KW Magnesium {ECO:0000256|PIRSR:PIRSR038134-2};
KW Membrane {ECO:0000256|PIRNR:PIRNR038134};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR038134-2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR038134}; Plastid {ECO:0000256|PIRNR:PIRNR038134};
KW Plastid outer membrane {ECO:0000256|PIRNR:PIRNR038134};
KW Protein transport {ECO:0000256|PIRNR:PIRNR038134};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Transmembrane {ECO:0000256|PIRNR:PIRNR038134};
KW Transport {ECO:0000256|PIRNR:PIRNR038134}.
FT DOMAIN 35..259
FT /note="AIG1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51720"
FT BINDING 47..52
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|PIRSR:PIRSR038134-1"
FT BINDING 51
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR038134-2"
FT BINDING 66..71
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|PIRSR:PIRSR038134-1"
FT BINDING 69
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR038134-2"
FT BINDING 161
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|PIRSR:PIRSR038134-1"
FT BINDING 209..210
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|PIRSR:PIRSR038134-1"
SQ SEQUENCE 324 AA; 36281 MW; FEEAAE38F7BAE102 CRC64;
MAAPIPREWT GLQQFPAATQ TKLHELLGKL KEENVSTLTI LVMGKGGVGK SSTVNSIVGE
RVATVSAFQS EGLRPTMCSR TRAGFTLNII DTPGLIEGGY INEQAVEIIK RFLLGKTVDV
LLYVDRLDAY RMDTLDEQVI RAITNSFGKD IWRRALVVLT HAQLSPPDGI DYNEFFTRRS
EALLRYIRSG AGINKREYGD FQLPIALVEN SGRCKTNEHG EKILPDGTPW VPNLMKEITV
VISNGSEPIH VDQKLIDGPN PNNRWKMFIP LILAVEYFLV VKGIRRAIHA DIANGKVDDW
EQRYRDLVGS RDPVEQKGSR NRKA
//
