ID K4B1I0_SOLLC Unreviewed; 475 AA.
AC K4B1I0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=MLO-like protein {ECO:0000256|RuleBase:RU280816};
GN Name=101252637 {ECO:0000313|EnsemblPlants:Solyc01g102520.3.1};
GN Synonyms=MLO {ECO:0000256|RuleBase:RU280816};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081 {ECO:0000313|EMBL:AOL57980.1};
RN [1] {ECO:0000313|EnsemblPlants:Solyc01g102520.3.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc01g102520.3.1};
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [2] {ECO:0000313|EMBL:AOL57980.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Fruit {ECO:0000313|EMBL:AOL57980.1};
RX PubMed=27579028; DOI=10.3389/fpls.2016.00380;
RA Zheng Z., Appiano M., Pavan S., Bracuto V., Ricciardi L., Visser R.G.,
RA Wolters A.M., Bai Y.;
RT "Genome-Wide Study of the Tomato SlMLO Gene Family and Its Functional
RT Characterization in Response to the Powdery Mildew Fungus Oidium
RT neolycopersici.";
RL Front. Plant Sci. 7:380-380(2016).
RN [3] {ECO:0000313|EnsemblPlants:Solyc01g102520.3.1}
RP IDENTIFICATION.
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc01g102520.3.1};
RG EnsemblPlants;
RL Submitted (JAN-2019) to UniProtKB.
CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC cell death. {ECO:0000256|RuleBase:RU280816}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280816}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU280816}.
CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC binds calmodulin in a calcium-dependent fashion.
CC {ECO:0000256|RuleBase:RU280816}.
CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000256|ARBA:ARBA00006574,
CC ECO:0000256|RuleBase:RU280816}.
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DR EMBL; KU759538; AOL57980.1; -; mRNA.
DR RefSeq; XP_004231310.1; XM_004231262.3.
DR AlphaFoldDB; K4B1I0; -.
DR STRING; 4081.K4B1I0; -.
DR PaxDb; 4081-Solyc01g102520-2-1; -.
DR EnsemblPlants; Solyc01g102520.3.1; Solyc01g102520.3.1; Solyc01g102520.3.
DR GeneID; 101252637; -.
DR Gramene; Solyc01g102520.3.1; Solyc01g102520.3.1; Solyc01g102520.3.
DR KEGG; sly:101252637; -.
DR eggNOG; ENOG502QSME; Eukaryota.
DR HOGENOM; CLU_024720_3_0_1; -.
DR InParanoid; K4B1I0; -.
DR OMA; MMERKPY; -.
DR OrthoDB; 368831at2759; -.
DR Proteomes; UP000004994; Chromosome 1.
DR ExpressionAtlas; K4B1I0; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR InterPro; IPR004326; Mlo.
DR PANTHER; PTHR31942; MLO-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR31942:SF54; MLO-LIKE PROTEIN 13; 1.
DR Pfam; PF03094; Mlo; 1.
PE 2: Evidence at transcript level;
KW Calmodulin-binding {ECO:0000256|RuleBase:RU280816};
KW Membrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius};
KW Pathogenesis-related protein {ECO:0000256|ARBA:ARBA00023265,
KW ECO:0000256|RuleBase:RU280816};
KW Plant defense {ECO:0000256|RuleBase:RU280816};
KW Reference proteome {ECO:0000313|Proteomes:UP000004994};
KW Transmembrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280816,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 475 AA; 54402 MW; C8F7D329AD10F154 CRC64;
MAEKSESSLE YTPTWVVAVV CFIIVLISLA AERGLHRLGK FFLQKNQDAL FKALQKLKEE
LMLLGFISLL LTVSQGAISQ ICVPENISKV MLPCKLKEAS TSKHLITGRH LLAGSSGEQH
CNHHEGKVPL LSLEALHQLH IFIFVLAVTH VIFCATTMVL GGAKIQQWRH WENSIQKQSK
PHHVHILHIQ SFVDRAGKRW RKYALISWTV AFFKQFYGSV TKSDYIVLRT GFIKKHCPSN
PTYNFHRYIL RTLEHDFKKI VGISWYLWLF VVLFLLINIA GWHSYFWLSF LPLVLLLLVG
TKLEHIITEL AQEVSERSSV VDETTPIKPS DELFWFDSPN LVLYLIHFIL FQNSFEIAFF
VWIWCTYGFK SCIMEDLGFI IPRLIIGVIV QVLCSYSTLP LYALVTQMGT TYKRGIFGEQ
TEDSLRIWAG TSSHNKMVTE TQESITVSNR PACNEIQDIS STVELSYPNK PHTTP
//
