ID K4DIA6_HUMAN Unreviewed; 582 AA.
AC K4DIA6;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Peroxidasin like {ECO:0000313|Ensembl:ENSP00000429855.1};
DE Flags: Fragment;
GN Name=PXDNL {ECO:0000313|Ensembl:ENSP00000429855.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000429855.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000429855.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000429855.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
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DR EMBL; AC011128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC012413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC103958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107374; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K4DIA6; -.
DR SMR; K4DIA6; -.
DR MassIVE; K4DIA6; -.
DR MaxQB; K4DIA6; -.
DR PeptideAtlas; K4DIA6; -.
DR Ensembl; ENST00000522628.5; ENSP00000429855.1; ENSG00000147485.13.
DR UCSC; uc064msq.1; human.
DR HGNC; HGNC:26359; PXDNL.
DR VEuPathDB; HostDB:ENSG00000147485; -.
DR GeneTree; ENSGT00940000163562; -.
DR HOGENOM; CLU_006087_2_2_1; -.
DR ChiTaRS; PXDNL; human.
DR Proteomes; UP000005640; Chromosome 8.
DR Bgee; ENSG00000147485; Expressed in cardiac muscle of right atrium and 96 other cell types or tissues.
DR ExpressionAtlas; K4DIA6; baseline and differential.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR PANTHER; PTHR11475:SF38; OXIDOREDUCTASE PXDNL-RELATED; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 1: Evidence at protein level;
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Proteomics identification {ECO:0007829|MaxQB:K4DIA6,
KW ECO:0007829|PeptideAtlas:K4DIA6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT BINDING 323
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000429855.1"
SQ SEQUENCE 582 AA; 64700 MW; 0552662F88B6CDDB CRC64;
NNLQQPTWGA ALTAFARLLQ PAYRDGIRAP RGLGLPVGSR QPLPPPRLVA TVWARAAAVT
PDHSYTRMLM HWGWFLEHDL DHTVPALSTA RFSDGRPCSS VCTNDPPCFP MNTRHADPRG
THAPCMLFAR SSPACASGRP SATVDSVYAR EQINQQTAYI DGSNVYGSSE RESQALRDPS
VPRGLLKTGF PWPPSGKPLL PFSTGPPTEC ARQEQESPCF LAGDHRANEH LALAAMHTLW
FREHNRMATE LSALNPHWEG NTVYQEARKI VGAELQHITY SHWLPKVLGD PGTRMLRGYR
GYNPNVNAGI INSFATAAFR FGHTLINPIL YRLNATLGEI SEGHLPFHKA LFSPSRIIKE
GGIDPVLRGL FGVAAKWRAP SYLLSPELTQ RLFSAAYSAA VDSAATIIQR GRDHGIPPYV
DFRVFCNLTS VKNFEDLQNE IKDSEIRQKL RKLYGSPGDI DLWPALMVED LIPGTRVGPT
LMCLFVTQFQ RLRDGDRFWY ENPGVFTPAQ LTQLKQASLS RVLCDNGDSI QQVQADVFVK
AEYPQDYLNC SEIPKVDLRV WQDCCADKQA GGTPEAGRVY RC
//
