ID K4IPX4_PSYTT Unreviewed; 1441 AA.
AC K4IPX4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Toxic metal ion efflux pump, CzcA family {ECO:0000313|EMBL:AFU67540.1};
GN OrderedLocusNames=P700755_000517 {ECO:0000313|EMBL:AFU67540.1};
OS Psychroflexus torquis (strain ATCC 700755 / ACAM 623).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Psychroflexus.
OX NCBI_TaxID=313595 {ECO:0000313|EMBL:AFU67540.1, ECO:0000313|Proteomes:UP000008514};
RN [1] {ECO:0000313|EMBL:AFU67540.1, ECO:0000313|Proteomes:UP000008514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700755 / ACAM 623 {ECO:0000313|Proteomes:UP000008514};
RA Bowman J., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K.,
RA Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFU67540.1, ECO:0000313|Proteomes:UP000008514}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700755 / ACAM 623 {ECO:0000313|Proteomes:UP000008514};
RA Feng S., Powell S.M., Bowman J.P.;
RT "The complete sequence of Psychroflexus torquis an extreme psychrophile
RT from sea-ice that is stimulated by light.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC family. {ECO:0000256|ARBA:ARBA00007613}.
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DR EMBL; CP003879; AFU67540.1; -; Genomic_DNA.
DR RefSeq; WP_015023158.1; NC_018721.1.
DR STRING; 313595.P700755_000517; -.
DR KEGG; ptq:P700755_000517; -.
DR eggNOG; COG1538; Bacteria.
DR eggNOG; COG3696; Bacteria.
DR HOGENOM; CLU_002755_1_2_10; -.
DR OrthoDB; 9758757at2; -.
DR Proteomes; UP000008514; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR Gene3D; 1.20.1600.10; Outer membrane efflux proteins (OEP); 1.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR InterPro; IPR003423; OMP_efflux.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR Pfam; PF02321; OEP; 2.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR SUPFAM; SSF56954; Outer membrane efflux proteins (OEP); 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 905..924
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 930..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 976..997
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1009..1034
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1441 AA; 160625 MW; 1F49EC90104E7AC4 CRC64;
MLSKIIEFSL KSKFFILLMV SCIVGFGVYS LTQIPIGAVP DITNNQVQVI TTSRNLSTTD
VEQFITYPVE LEMVNLPGVK EIRSVSKFGL SVVTIVFEDD LGTYLPRQLI AEKLKSAAEK
IPSGFGTPEM GPITTGLGEI YQYTLETKPG YEDQYDATEL RTIQDWIVRR QLSGIPGVVE
INTWGGYLKE YEVSINSKRL QANNITIAEV FQALENNNSV AGGSYIEKNE EAYFIRGEGL
IKSLEDIKNI SVTTRNNQPV YIKDIAEVGF GYARRFGAVT GNGEGEKVLG QVMMLKDADS
KRVIDAVKIR IAEIETTLPE GVYINGFLDR SELIQRTTYT IAENLLLGFL VVAFIVVLLI
GDWRAGLVIS SIIPLSFLIA ISLMYIFGVD ANLMSLGALD FGIIIDGAVI IVEFVAFKLW
QRSNEFSNKT STEINILKDK ITSKGASKML NSAIFGQLII LIVFIPILSL SGIEGKMFRP
MALTFSFALI GAMILCFTWV PVACSLILKP QSKSSFTIST KLLNGVKRLY LPSIKWALNH
TKPVLISAVV LLALGVFTFT RMGAEFVPTL DEGDFVIQPI LKTGKSLKST VERTTAIEKI
LLEQFPEVTQ VVSRIGAAEV PTDPMSMQDS DIIVRLKPKS EWTSADTKEG LAEKIDEALS
VFPGMDLEFT QPIEMRFNEL ITGVRSDIAI KVFGEDLDVL ARKGNEIKSL IENVEGAADI
SVEKIVGLPQ MLVNYKRDKI GRYGLDIKSI NEVITAGFAG RTTGVVFEGE KRFDLVVRLQ
DTERQDIDDL RNLMIDTPGY GKIPLNEVAD ITFDRGPAKI SRDESKRRIV VGVNVRNRDL
ESVVTDIQKI IDENLDLPVG YTMTYGGQFE NLESAKARLK IAVPIALVLI YIMLFFALRT
HKDALLIFTA IPFSAVGGVF LLWLRDMPFS ISAGVGFIAL FGIAVLNGII LVEYFKDILK
THDKLSLQHI IDATQDRLRA VLLTASSTAL GFLPMAISTG AGAEVQRPLA TVVIGGLITS
TLLTLIILPV LYALKNNVTK LRLNPKPSLF ILMMGCAGFT ANAQDDEFES LKTQMLDNNK
QLKAAQLRAE STEAAEGQAF TFNNAQIYQN YDESEADPIA NQPLYQWGII QQFDFPTVYG
SRLKLNKVKT KLARTQYSIV EIRKIKTLQV NYQNYLEAVA KLEIYDSIYK IYTDFSRMAK
RKFEEGESNY LEKITAQSKA NQITIEQEQL KQELTHSILA IKGLLQSQES LVLREKTLYK
LQLNMENTSS ENLSLSALEL DQKLAKRNSA LAKNELLPGI SASYFIRSNS AIDKNFNGYQ
IGLNIPLLFF GDRSKIKSAE ITTLAKQAAL EDAQIDLTQQ KDQLINQLSV QQDALNNYEE
NQLKIADELL KTAKLSYKAG EIDFFRYVQS LEYAQRIQLD YLTKLRDYNQ TIIALNYFLL
N
//
