ID K4LCZ7_THEPS Unreviewed; 503 AA.
AC K4LCZ7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Methylthiotransferase {ECO:0000313|EMBL:AFV10801.1};
GN OrderedLocusNames=Tph_c05630 {ECO:0000313|EMBL:AFV10801.1};
OS Thermacetogenium phaeum (strain ATCC BAA-254 / DSM 26808 / PB).
OC Bacteria; Bacillota; Clostridia; Thermoanaerobacterales;
OC Thermoanaerobacteraceae; Thermacetogenium.
OX NCBI_TaxID=1089553 {ECO:0000313|EMBL:AFV10801.1, ECO:0000313|Proteomes:UP000000467};
RN [1] {ECO:0000313|EMBL:AFV10801.1, ECO:0000313|Proteomes:UP000000467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-254 / DSM 26808 / PB
RC {ECO:0000313|Proteomes:UP000000467};
RX PubMed=23259483; DOI=10.1186/1471-2164-13-723;
RA Oehler D., Poehlein A., Leimbach A., Muller N., Daniel R., Gottschalk G.,
RA Schink B.;
RT "Genome-guided analysis of physiological and morphological traits of the
RT fermentative acetate oxidizer Thermacetogenium phaeum.";
RL BMC Genomics 13:723-723(2012).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP003732; AFV10801.1; -; Genomic_DNA.
DR RefSeq; WP_015049719.1; NZ_KI912609.1.
DR AlphaFoldDB; K4LCZ7; -.
DR STRING; 1089553.Tph_c05630; -.
DR KEGG; tpz:Tph_c05630; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_021572_4_4_9; -.
DR OrthoDB; 9801659at2; -.
DR Proteomes; UP000000467; Chromosome.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000467};
KW Transferase {ECO:0000313|EMBL:AFV10801.1}.
FT DOMAIN 8..149
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 186..413
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 503 AA; 55952 MW; 4FD94E2580F9E806 CRC64;
MRVVLLEHPR AVVPERCNDI ANTPLASCLL TGYTAGVLQE AGHEVEIVEG YLDHLSYEEI
GRRIGDAVPG LLGVHMVYQW QRDRLLFDFL EGLKASGAVP YIAVYGYYPT FAFDAVLREC
TAVDAVVVGE PELTFAELAG RLARGGEIGG IPGLAVRDAD GGIRCTRREP VKDLDRLPFP
VRTPAMMRLP EVNLQGSRGC YGGCTFCYIN PFYGQGSHWR GRSPENIAAE IDKILEKWGK
RDFYFTDPNF FGPGERGQKR ALRLASLLKD RGVRFGIEAR VNDIRDETIG ALVAAGLRSI
LIGLESGRDE SLQRMNKRTT VAQNEAALRI LRKHGIEPNV GFIMFEPDST LEDVRANFEF
LKRNRLLEKL EITANVLYHH QIVLKGTPAY RELDRSGRLR ISDNPYEGTA VYENDGVACL
AEVMRGLTNF LFTRLSGVWS GRVQPPPEAP EIFRRANAHL VECFETILST LEAGGCLQEA
ERDAFVKRHE LHLAGLLAGI PEG
//