ID K4MSQ7_9MONO Unreviewed; 695 AA.
AC K4MSQ7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Nucleoprotein {ECO:0000256|ARBA:ARBA00014389, ECO:0000256|PIRNR:PIRNR003900};
DE AltName: Full=Nucleocapsid protein {ECO:0000256|ARBA:ARBA00033344, ECO:0000256|PIRNR:PIRNR003900};
GN Name=NP {ECO:0000313|EMBL:AFV31241.1};
OS Orthomarburgvirus marburgense.
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Filoviridae; Orthomarburgvirus.
OX NCBI_TaxID=3052505 {ECO:0000313|EMBL:AFV31241.1, ECO:0000313|Proteomes:UP000136689};
RN [1] {ECO:0000313|Proteomes:UP000101191, ECO:0000313|Proteomes:UP000106553}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MARV/H.sapiens-tc/COD/2000/12 DRC
RC {ECO:0000313|EMBL:AFV31248.1}, MARV/H.sapiens-tc/COD/2000/13 DRC
RC {ECO:0000313|EMBL:AFV31283.1}, MARV/H.sapiens-tc/COD/2000/15 DRC
RC {ECO:0000313|EMBL:AFV31297.1}, MARV/H.sapiens-tc/COD/2000/16 DRC
RC {ECO:0000313|EMBL:AFV31241.1}, MARV/H.sapiens-tc/COD/2000/17 DRC
RC {ECO:0000313|EMBL:AFV31234.1}, MARV/H.sapiens-tc/COD/2000/18 DRC
RC {ECO:0000313|EMBL:AFV31262.1}, MARV/H.sapiens-tc/COD/2000/20 DRC
RC {ECO:0000313|EMBL:AFV31255.1}, MARV/H.sapiens-tc/COD/2000/21 DRC
RC {ECO:0000313|EMBL:AFV31269.1}, MARV/H.sapiens-tc/COD/2000/22 DRC
RC {ECO:0000313|EMBL:AFV31304.1}, MARV/H.sapiens-tc/COD/2000/25 DRC
RC {ECO:0000313|EMBL:AFV31311.1}, MARV/H.sapiens-tc/COD/2000/26 DRC
RC {ECO:0000313|EMBL:AFV31276.1}, MARV/H.sapiens-tc/COD/2000/27 DRC
RC {ECO:0000313|EMBL:AFV31227.1}, MARV/H.sapiens-tc/COD/2000/28 DRC
RC {ECO:0000313|EMBL:AFV31290.1}, MARV/H.sapiens-tc/COD/2000/29 DRC
RC {ECO:0000313|EMBL:AFV31220.1}, and MARV/H.sapiens-tc/COD/2000/33 DRC
RC {ECO:0000313|EMBL:AFV31318.1};
RX PubMed=23055920; DOI=10.1371/journal.ppat.1002877;
RA Amman B.R., Carroll S.A., Reed Z.D., Sealy T.K., Balinandi S.,
RA Swanepoel R., Kemp A., Erickson B.R., Comer J.A., Campbell S., Cannon D.L.,
RA Khristova M.L., Atimnedi P., Paddock C.D., Kent Crockett R.J.,
RA Flietstra T.D., Warfield K.L., Unfer R., Katongole-Mbidde E., Downing R.,
RA Tappero J.W., Zaki S.R., Rollin P.E., Ksiazek T.G., Nichol S.T.,
RA Towner J.S.;
RT "Seasonal Pulses of Marburg Virus Circulation in Juvenile Rousettus
RT aegyptiacus Bats Coincide with Periods of Increased Risk of Human
RT Infection.";
RL PLoS Pathog. 8:E1002877-E1002877(2012).
CC -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. The
CC encapsidated genomic RNA is termed the nucleocapsid and serves as
CC template for transcription and replication. During replication,
CC encapsidation by NP is coupled to RNA synthesis and all replicative
CC products are resistant to nucleases. {ECO:0000256|ARBA:ARBA00025530}.
CC -!- SUBUNIT: Homooligomer. Homomultimerizes to form the nucleocapsid. Binds
CC to viral genomic RNA. Interacts with VP35 and VP30 to form the
CC nucleocapsid. Also interacts with VP24 and VP40.
CC {ECO:0000256|ARBA:ARBA00026090}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|PIRNR:PIRNR003900}. Host
CC cytoplasm {ECO:0000256|PIRNR:PIRNR003900}.
CC -!- SIMILARITY: Belongs to the filoviruses nucleoprotein family.
CC {ECO:0000256|ARBA:ARBA00005492, ECO:0000256|PIRNR:PIRNR003900}.
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DR EMBL; JX458836; AFV31220.1; -; Viral_cRNA.
DR EMBL; JX458837; AFV31227.1; -; Viral_cRNA.
DR EMBL; JX458838; AFV31234.1; -; Viral_cRNA.
DR EMBL; JX458839; AFV31241.1; -; Viral_cRNA.
DR EMBL; JX458840; AFV31248.1; -; Viral_cRNA.
DR EMBL; JX458841; AFV31255.1; -; Viral_cRNA.
DR EMBL; JX458842; AFV31262.1; -; Viral_cRNA.
DR EMBL; JX458843; AFV31269.1; -; Viral_cRNA.
DR EMBL; JX458844; AFV31276.1; -; Viral_cRNA.
DR EMBL; JX458845; AFV31283.1; -; Viral_cRNA.
DR EMBL; JX458846; AFV31290.1; -; Viral_cRNA.
DR EMBL; JX458847; AFV31297.1; -; Viral_cRNA.
DR EMBL; JX458848; AFV31304.1; -; Viral_cRNA.
DR EMBL; JX458849; AFV31311.1; -; Viral_cRNA.
DR EMBL; JX458850; AFV31318.1; -; Viral_cRNA.
DR Proteomes; UP000101191; Genome.
DR Proteomes; UP000106553; Genome.
DR Proteomes; UP000106713; Genome.
DR Proteomes; UP000116246; Genome.
DR Proteomes; UP000126198; Genome.
DR Proteomes; UP000130560; Genome.
DR Proteomes; UP000134304; Genome.
DR Proteomes; UP000135556; Genome.
DR Proteomes; UP000136689; Genome.
DR Proteomes; UP000136840; Genome.
DR Proteomes; UP000158939; Genome.
DR Proteomes; UP000160801; Genome.
DR Proteomes; UP000163184; Genome.
DR Proteomes; UP000165241; Genome.
DR Proteomes; UP000168333; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039702; P:viral budding via host ESCRT complex; IEA:UniProtKB-KW.
DR GO; GO:0019074; P:viral RNA genome packaging; IEA:UniProtKB-UniRule.
DR InterPro; IPR008609; Ebola_NP.
DR Pfam; PF05505; Ebola_NP; 1.
DR PIRSF; PIRSF003900; N_FiloV; 1.
PE 3: Inferred from homology;
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561,
KW ECO:0000256|PIRNR:PIRNR003900};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Host cytoplasm {ECO:0000256|PIRNR:PIRNR003900};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022462};
KW Ribonucleoprotein {ECO:0000256|PIRNR:PIRNR003900};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR003900};
KW Viral budding {ECO:0000256|ARBA:ARBA00022637};
KW Viral budding via the host ESCRT complexes {ECO:0000256|ARBA:ARBA00022462};
KW Viral nucleoprotein {ECO:0000256|ARBA:ARBA00023086,
KW ECO:0000256|PIRNR:PIRNR003900};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00022612};
KW Virion {ECO:0000256|PIRNR:PIRNR003900}.
FT REGION 412..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 77600 MW; 534A87F1A12FD85A CRC64;
MDLHSLLELG TKPTAPHVRN KKVILFDTNH QVSICNQIID AINSGIDLGD LLEGGLLTLC
VEHYYNSDKD KFNTSPIAKY LRDAGYEFDV IKNADATRFL DVIPNEPHYS PLILALKTLE
STESQRGRIG LFLSFCSLFL PKLVVGDRAS IEKALRQVTV HQEQGIVTYP NHWLTTGHMK
VIFGILRSSF ILKFVLIHQG VNLVTGHDAY DSIISNSVGQ TRFSGLLIVK TVLEFILQKT
DSGVTLHPLV RTSKVKNEVA SFKQALSNLA RHGEYAPFAR VLNLSGINNL EHGLYPQLSA
IALGVATAHG STLAGVNVGE QYQQLREAAH DAEVKLQRRH EHQEIQAIAE DDEERKILEQ
FHLQKTEITH SQTLAVLSQK REKLARLAAE IENNIVEDQG FKQSQNRVSQ SFLNDPTPVE
VTVQARPVNR PTALPPPVDD KIEHESTGDS SSSSSFVDLN DPFALLNEDE DTLDDSVMIP
STTSREFQGI PESPGQSQDL DNSQGKQEDE STNPIKKQFL RYQELPPVQE DDESEYTTDS
QESIDQPGSD NEQGVDLPPP PLYTQEKRQD PIQHPAASSQ DPFGSIGDVN GDILEPIRSP
SSPSAPQEDT RAREAYELSP DFTNYEDNQQ NWPQRVVTKK GRTFLYPNDL LQTSPPESLV
TALVEEYQNP VSAKELQADW PDMSFDERRH VAMNL
//
