ID   K4R111_STRDJ            Unreviewed;       601 AA.
AC   K4R111;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase PaaC {ECO:0000313|EMBL:CCK26329.1};
GN   ORFNames=BN159_1950 {ECO:0000313|EMBL:CCK26329.1};
OS   Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1214101 {ECO:0000313|EMBL:CCK26329.1, ECO:0000313|Proteomes:UP000008043};
RN   [1] {ECO:0000313|EMBL:CCK26329.1, ECO:0000313|Proteomes:UP000008043}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 101723 / JCM 4913 / KCC S-0913 / 768
RC   {ECO:0000313|Proteomes:UP000008043};
RX   PubMed=23043000; DOI=10.1128/JB.01592-12;
RA   Jankowitsch F., Schwarz J., Ruckert C., Gust B., Szczepanowski R., Blom J.,
RA   Pelzer S., Kalinowski J., Mack M.;
RT   "Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and
RT   heterologous production of the unique antibiotic roseoflavin.";
RL   J. Bacteriol. 194:6818-6827(2012).
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
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DR   EMBL; HE971709; CCK26329.1; -; Genomic_DNA.
DR   RefSeq; WP_015656723.1; NC_020504.1.
DR   AlphaFoldDB; K4R111; -.
DR   STRING; 1214101.BN159_1950; -.
DR   KEGG; sdv:BN159_1950; -.
DR   PATRIC; fig|1214101.3.peg.1980; -.
DR   eggNOG; COG1250; Bacteria.
DR   HOGENOM; CLU_009834_21_0_11; -.
DR   OrthoDB; 9771883at2; -.
DR   Proteomes; UP000008043; Chromosome.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 2.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008043}.
FT   DOMAIN          15..193
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          196..292
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          322..499
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          502..598
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   601 AA;  63267 MW;  33D3CC3EA198739E CRC64;
     MATPLSDTPQ SSIRTVAVVG LGTMGTGIAE VLAKAGREVI GIDVCDAAAA QSLAALEAST
     ARAVERGKLT EQDRTAALAR IRTATDLAAA ADADLVIEVA PESYEIKQQI FRALDGIVRP
     ETILATGTNA LSVTRLAADS ARPERVLGLH FFNPAPAMRL VEVVSSVLTA PAAVTAVTNL
     ALDLGKEPVA VGDRPGFVAD GLLFGYLNQA AAMYEAKYAS REDIDAAMRL GCGLPMGPLA
     LLDLIGIDTA RTVLDAMYAE SRDRLHAPAP ILKQLSEAGL TGRKSGRGFY SYEAPGSSVV
     VRDALTPLEG ETLAQGREVR SVGVAGSGTM ASGIAEVFAK AGYEVVLAAR SEEKAQAARA
     RIGKSLARSV DKGRMTAEAA ARTLDLITPA GSYDAFAEVD LAVEAVAEDL EIKQQLFATL
     DKVCKPGAVL ATTTSSLPVV ACARATSRPQ DVIGMHFFNP APAMKLVEVV RTVLTADDVH
     ATVREVCGRI RKHAVDCGDR AGFIVNALLF PYLNNAIKMV QEHYATLDDI DAAMKLGGGY
     PMGPFELLDV VGLDVSLAIE KVLHREFRDP GLAPAPLLEH LVAAGCLGRK TGRGFREYAR
     R
//