ID K4R198_STRDJ Unreviewed; 408 AA.
AC K4R198;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Granaticin polyketide putative beta-ketoacyl synthase 1 {ECO:0000313|EMBL:CCK26850.1};
DE EC=2.3.1.- {ECO:0000313|EMBL:CCK26850.1};
GN ORFNames=BN159_2471 {ECO:0000313|EMBL:CCK26850.1};
OS Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1214101 {ECO:0000313|EMBL:CCK26850.1, ECO:0000313|Proteomes:UP000008043};
RN [1] {ECO:0000313|EMBL:CCK26850.1, ECO:0000313|Proteomes:UP000008043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 101723 / JCM 4913 / KCC S-0913 / 768
RC {ECO:0000313|Proteomes:UP000008043};
RX PubMed=23043000; DOI=10.1128/JB.01592-12;
RA Jankowitsch F., Schwarz J., Ruckert C., Gust B., Szczepanowski R., Blom J.,
RA Pelzer S., Kalinowski J., Mack M.;
RT "Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and
RT heterologous production of the unique antibiotic roseoflavin.";
RL J. Bacteriol. 194:6818-6827(2012).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; HE971709; CCK26850.1; -; Genomic_DNA.
DR AlphaFoldDB; K4R198; -.
DR STRING; 1214101.BN159_2471; -.
DR KEGG; sdv:BN159_2471; -.
DR PATRIC; fig|1214101.3.peg.2508; -.
DR eggNOG; COG0304; Bacteria.
DR HOGENOM; CLU_000022_69_2_11; -.
DR Proteomes; UP000008043; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000313|EMBL:CCK26850.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008043};
KW Transferase {ECO:0000256|RuleBase:RU003694, ECO:0000313|EMBL:CCK26850.1}.
FT DOMAIN 1..406
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 408 AA; 42063 MW; B780A73BCBA83B07 CRC64;
MVAPGGIGTK DYWALLTGGR AATRYTTFFD ASTYRSRVAA EVDFDPAAAG LGVREIHRMD
RSAQFAVVSA WEAVADSGLA LGGLDPLRTG VSIGSAVGAA TSLDQAYPLL SDEGRDWRTD
TTYAVPQLYD YMVPSALARE VAWTVAAQGP VALVSTGCTS GLDALGHAAG IIAEGSADVM
LAGAAEAPVC AITAASFDAI KATTPYEGDD PAEACRPFDL DRDGFVLGEG GAILVVEEKE
HARRRGAHVY AEIAGFATRG NAFHMTGLRP DGTELAAAVG AALDEARLPA DAVDYVNAHG
SGTRQNDVHE TNALKLSLGS HAYDVPVSSI KSMIGHSLGA IGSLEAAACA LALENGAVPP
TANLHTPDPE CDLDYVPLTA RAQPLNTVLS VGSGFGGLQS ALVLRKPE
//
