ID K4R3G4_STRDJ Unreviewed; 642 AA.
AC K4R3G4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Succinate dehydrogenase flavoprotein subunit {ECO:0000313|EMBL:CCK27682.1};
GN ORFNames=BN159_3303 {ECO:0000313|EMBL:CCK27682.1};
OS Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1214101 {ECO:0000313|EMBL:CCK27682.1, ECO:0000313|Proteomes:UP000008043};
RN [1] {ECO:0000313|EMBL:CCK27682.1, ECO:0000313|Proteomes:UP000008043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 101723 / JCM 4913 / KCC S-0913 / 768
RC {ECO:0000313|Proteomes:UP000008043};
RX PubMed=23043000; DOI=10.1128/JB.01592-12;
RA Jankowitsch F., Schwarz J., Ruckert C., Gust B., Szczepanowski R., Blom J.,
RA Pelzer S., Kalinowski J., Mack M.;
RT "Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and
RT heterologous production of the unique antibiotic roseoflavin.";
RL J. Bacteriol. 194:6818-6827(2012).
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DR EMBL; HE971709; CCK27682.1; -; Genomic_DNA.
DR RefSeq; WP_015658059.1; NC_020504.1.
DR AlphaFoldDB; K4R3G4; -.
DR STRING; 1214101.BN159_3303; -.
DR KEGG; sdv:BN159_3303; -.
DR PATRIC; fig|1214101.3.peg.3351; -.
DR eggNOG; COG1053; Bacteria.
DR HOGENOM; CLU_014312_8_1_11; -.
DR OrthoDB; 9805351at2; -.
DR Proteomes; UP000008043; Chromosome.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR030664; SdhA/FrdA/AprA.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR PANTHER; PTHR11632:SF89; SUCCINATE DEHYDROGENASE [IRON-SULFUR SUBUNIT] (SUCCINIC DEHYDROGENASE)-RELATED; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR PIRSF; PIRSF000171; SDHA_APRA_LASPO; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008043}.
FT DOMAIN 10..430
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 491..578
FT /note="Fumarate reductase/succinate dehydrogenase
FT flavoprotein-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02910"
FT ACT_SITE 322
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000171-1"
SQ SEQUENCE 642 AA; 71150 MW; D2EF5D82F03B10EE CRC64;
MSVVDRQEWD VVVIGAGGAG LRAAIEARER GARTAVICKS LFGKAHTVMA EGGIAAAMAN
VNEHDSWQVH FRDTMRGGKF LNQWRMAELH AQEAPDRVWE LETWGALFDR TKDGKISQRN
FGGHEYPRLA HVGDRTGLEL IRTLQQKIVS LQQQDFKETG DYESRLKVFQ ECTVTRVLKD
GPRVSGVFAY DRETGRFFVL EAPAVVIATG GIGKSFKVTS NSWEYTGDGH ALALLAGAPL
LNMEFVQFHP TGMVWPPSVK GILVTESVRG DGGVLRNSEG KRFMFDYVPD VFKEKYAESE
EEGDRWYDDP DNNRRPPELL PRDEVARAIN SEVKAGRGSP HGGVFLDVST RMPAEVIKRR
LPSMYHQFKE LADVDITAEA MEVGPTCHYV MGGIAVDSDT AAARGVPGLF AAGEVAGGMH
GSNRLGGNSL SDLLVFGRRA GWHAAEYTAA LAFERPEVDD VQIDTAAAEA LRPFSAESPD
EAAPENPYSL HQELQQTMND LVGIIRREGE MAHALEKLGE LRVRARRAGV EGHRQFNPGW
HLALDLRNML LVSECVARAA LERSESRGGH TREDHPTMER VWRNINLLCR LADPTGGLAA
TDPERGQIDL TRETTDPIRP DLLALFDKEE LVKYLAEEEL YE
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