ID K4R3Y7_STRDJ Unreviewed; 325 AA.
AC K4R3Y7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Daunorubicin/doxorubicin resistance ATP-binding protein DrrA {ECO:0000313|EMBL:CCK27822.1};
DE EC=3.6.3.- {ECO:0000313|EMBL:CCK27822.1};
GN Name=drrA3 {ECO:0000313|EMBL:CCK27822.1};
GN ORFNames=BN159_3443 {ECO:0000313|EMBL:CCK27822.1};
OS Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1214101 {ECO:0000313|EMBL:CCK27822.1, ECO:0000313|Proteomes:UP000008043};
RN [1] {ECO:0000313|EMBL:CCK27822.1, ECO:0000313|Proteomes:UP000008043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 101723 / JCM 4913 / KCC S-0913 / 768
RC {ECO:0000313|Proteomes:UP000008043};
RX PubMed=23043000; DOI=10.1128/JB.01592-12;
RA Jankowitsch F., Schwarz J., Ruckert C., Gust B., Szczepanowski R., Blom J.,
RA Pelzer S., Kalinowski J., Mack M.;
RT "Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and
RT heterologous production of the unique antibiotic roseoflavin.";
RL J. Bacteriol. 194:6818-6827(2012).
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DR EMBL; HE971709; CCK27822.1; -; Genomic_DNA.
DR RefSeq; WP_015658199.1; NC_020504.1.
DR AlphaFoldDB; K4R3Y7; -.
DR STRING; 1214101.BN159_3443; -.
DR KEGG; sdv:BN159_3443; -.
DR PATRIC; fig|1214101.3.peg.3494; -.
DR eggNOG; COG1131; Bacteria.
DR HOGENOM; CLU_000604_1_2_11; -.
DR OrthoDB; 9804819at2; -.
DR Proteomes; UP000008043; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR005894; DrrA.
DR InterPro; IPR025302; DUF4162.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01188; drrA; 1.
DR PANTHER; PTHR42711; ABC TRANSPORTER ATP-BINDING PROTEIN; 1.
DR PANTHER; PTHR42711:SF18; DOXORUBICIN RESISTANCE ATP-BINDING PROTEIN DRRA; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF13732; DUF4162; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:CCK27822.1};
KW Hydrolase {ECO:0000313|EMBL:CCK27822.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008043};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 5..235
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 325 AA; 35093 MW; C89D46D90A52EEB4 CRC64;
MPGAIHAEGL VKTFGDVRAL DGVDLDVPEG TVLGLLGPNG AGKTTTVRCL TTLLRPDSGK
AVVAGVDVLK HPDAVRRSIG LSGQFAAVDE YLTGRENLQM VGRLYQMRAK AAKARAQELL
EQFDLADAAD RPTKTYSGGM RRRLDLAAAL VVSPPVMFMD EPTTGLDPRN RQLLWEVIKK
LVSGGTTLLL TTQYLEEADH LAHDIAVVDH GHVIAQGTSD QLKARTGGER VEVVVHEREH
MATAAEVLSG FGKGETTVED HMRMLTVPVT GGAKLLAEVI RELDTRGIEI DDIGLRRPTL
DDVFLSLTGH IAEEKNAETD KETVK
//
