ID K4R4L9_STRDJ Unreviewed; 597 AA.
AC K4R4L9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Cholesterol oxidase {ECO:0000313|EMBL:CCK28015.1};
DE EC=1.1.3.6 {ECO:0000313|EMBL:CCK28015.1};
GN Name=choD {ECO:0000313|EMBL:CCK28015.1};
GN ORFNames=BN159_3636 {ECO:0000313|EMBL:CCK28015.1};
OS Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1214101 {ECO:0000313|EMBL:CCK28015.1, ECO:0000313|Proteomes:UP000008043};
RN [1] {ECO:0000313|EMBL:CCK28015.1, ECO:0000313|Proteomes:UP000008043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 101723 / JCM 4913 / KCC S-0913 / 768
RC {ECO:0000313|Proteomes:UP000008043};
RX PubMed=23043000; DOI=10.1128/JB.01592-12;
RA Jankowitsch F., Schwarz J., Ruckert C., Gust B., Szczepanowski R., Blom J.,
RA Pelzer S., Kalinowski J., Mack M.;
RT "Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and
RT heterologous production of the unique antibiotic roseoflavin.";
RL J. Bacteriol. 194:6818-6827(2012).
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DR EMBL; HE971709; CCK28015.1; -; Genomic_DNA.
DR RefSeq; WP_015658392.1; NC_020504.1.
DR AlphaFoldDB; K4R4L9; -.
DR STRING; 1214101.BN159_3636; -.
DR KEGG; sdv:BN159_3636; -.
DR PATRIC; fig|1214101.3.peg.3690; -.
DR eggNOG; COG2303; Bacteria.
DR HOGENOM; CLU_002483_2_0_11; -.
DR OrthoDB; 517968at2; -.
DR Proteomes; UP000008043; Chromosome.
DR GO; GO:0016995; F:cholesterol oxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 3.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR47470; CHOLESTEROL OXIDASE; 1.
DR PANTHER; PTHR47470:SF1; FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:CCK28015.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008043}.
FT DOMAIN 204..293
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 485..542
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT REGION 547..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 597 AA; 64296 MW; 77BC26D1892991CF CRC64;
MSNDADDNDA YDYDVLVVGS GFGGSVTALR LTEKGYKVGV LEAGRRFTRE SLPKNSWDLK
NFLWAPKLGM FGIQRIHLLG NVMVLAGAGV GGGSLNYANT LYVPPKPFFD DPQWRDITDW
QEELKPYYDQ AQRMLGVRLN PTMTPSDVHL KDAAQKMGVG DSFHMAPVGV FFGDGEDADG
ATKAKPGQQV DDPYFGGAGP ARKACTECGE CMTGCRHGAK NTLNENYLYL AEKAGAVVHP
MTTVVSVTDD SRGGYAVTTL PTDRKKKGES RVFKARRVVL AAGTYGTQTL LHRMKASGRL
PYLSPKLGEL TRTNSEALVG AQTDDRRYRK ATGEKKVDFT RGVAITSSVH PDTNTHIEPV
RYGKGSNSMG SLTILQVPYT EGASRLAAWL GNAARHPLLI MRSLSNRRWS EKTIIGLVMQ
SLDNSLTTYL KPDGVGKGML TARQGHGSPN PMQIKAATEG ASALAESING FPGSNVGELM
GTPLTAHFLG GCPIGASRES GVIDPYHRLY GHPGISVVDG AAVSANLGVN PSLTITAQAE
RAMSYWPNKG EEDPRPAQDQ PYERLQAVEP KQPAVPAEAF GALRLPFLGM PTVPPKK
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