ID K4R541_STRDJ Unreviewed; 397 AA.
AC K4R541;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Dolichol-phosphate mannosyltransferase {ECO:0000313|EMBL:CCK27804.1};
GN Name=dpm {ECO:0000313|EMBL:CCK27804.1};
GN ORFNames=BN159_3425 {ECO:0000313|EMBL:CCK27804.1};
OS Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1214101 {ECO:0000313|EMBL:CCK27804.1, ECO:0000313|Proteomes:UP000008043};
RN [1] {ECO:0000313|EMBL:CCK27804.1, ECO:0000313|Proteomes:UP000008043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 101723 / JCM 4913 / KCC S-0913 / 768
RC {ECO:0000313|Proteomes:UP000008043};
RX PubMed=23043000; DOI=10.1128/JB.01592-12;
RA Jankowitsch F., Schwarz J., Ruckert C., Gust B., Szczepanowski R., Blom J.,
RA Pelzer S., Kalinowski J., Mack M.;
RT "Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and
RT heterologous production of the unique antibiotic roseoflavin.";
RL J. Bacteriol. 194:6818-6827(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006739}.
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DR EMBL; HE971709; CCK27804.1; -; Genomic_DNA.
DR RefSeq; WP_015658181.1; NC_020504.1.
DR AlphaFoldDB; K4R541; -.
DR STRING; 1214101.BN159_3425; -.
DR KEGG; sdv:BN159_3425; -.
DR PATRIC; fig|1214101.3.peg.3476; -.
DR eggNOG; COG1215; Bacteria.
DR HOGENOM; CLU_039727_1_0_11; -.
DR OrthoDB; 9810303at2; -.
DR Proteomes; UP000008043; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004582; F:dolichyl-phosphate beta-D-mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR CDD; cd06442; DPM1_like; 1.
DR InterPro; IPR039528; DPM1-like.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR007267; GtrA_DPMS_TM.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43398:SF2; DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43398; DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF04138; GtrA; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000313|EMBL:CCK27804.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008043};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CCK27804.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..193
FT /note="Glycosyltransferase 2-like"
FT /evidence="ECO:0000259|Pfam:PF00535"
FT DOMAIN 262..376
FT /note="GtrA/DPMS transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04138"
SQ SEQUENCE 397 AA; 43310 MW; 136849A032898910 CRC64;
MSQEYTTPVP DLEASEVPEP GAVTIVVPTF NESANIRELL HQITESVPAR LPCEVVFVDD
STDDTPEVIK EAAQDCPFPV AVIHRDEPAG GLGGAVVEGL KAATSDWIVV MDGDCQHPPS
LVPELVATGE RAGAELVVAS RYIKGGSRAG LAGSYRVAVS RGATWLTKSL FPRRLHGISD
PMSGFFAIRR QAVTADVLKP LGYKILLELA VRSRPRQVAE VPFVFQDRFA GESKSTAQEG
LRFLRHLVGL RTATPAARMI GFGLIGASGF LPNLLALWIL TGLGMHYLPA EIVANQFGVA
WNFLLIEHLL FRDRRLHRRW WDRAGRFALL ANADLVLRIP LIALFVHQLG MDALTATAVA
LVTTFVLRFA ATEALVYLPR RKSGGEQHRS RTARSTA
//
