ID K4R9P8_STRDJ Unreviewed; 984 AA.
AC K4R9P8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Regulatory protein AfsR {ECO:0000313|EMBL:CCK29394.1};
GN Name=afsR {ECO:0000313|EMBL:CCK29394.1};
GN ORFNames=BN159_5015 {ECO:0000313|EMBL:CCK29394.1};
OS Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1214101 {ECO:0000313|EMBL:CCK29394.1, ECO:0000313|Proteomes:UP000008043};
RN [1] {ECO:0000313|EMBL:CCK29394.1, ECO:0000313|Proteomes:UP000008043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 101723 / JCM 4913 / KCC S-0913 / 768
RC {ECO:0000313|Proteomes:UP000008043};
RX PubMed=23043000; DOI=10.1128/JB.01592-12;
RA Jankowitsch F., Schwarz J., Ruckert C., Gust B., Szczepanowski R., Blom J.,
RA Pelzer S., Kalinowski J., Mack M.;
RT "Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and
RT heterologous production of the unique antibiotic roseoflavin.";
RL J. Bacteriol. 194:6818-6827(2012).
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
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DR EMBL; HE971709; CCK29394.1; -; Genomic_DNA.
DR RefSeq; WP_015659734.1; NC_020504.1.
DR AlphaFoldDB; K4R9P8; -.
DR STRING; 1214101.BN159_5015; -.
DR KEGG; sdv:BN159_5015; -.
DR PATRIC; fig|1214101.3.peg.5084; -.
DR eggNOG; COG3629; Bacteria.
DR eggNOG; COG3903; Bacteria.
DR HOGENOM; CLU_004665_2_0_11; -.
DR OrthoDB; 3845029at2; -.
DR Proteomes; UP000008043; Chromosome.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 4.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01091}; Reference proteome {ECO:0000313|Proteomes:UP000008043};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 16..112
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT REPEAT 854..887
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DNA_BIND 16..112
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 105687 MW; 08A045667D90973A CRC64;
MDGVPRVPEQ RRGGRDGSTE PTALRFSVLG PVRAWRGEEA LNTGSPQQRA LLAALLLREG
RTATAAELID ALWGEEPPSQ ALAALRTYAS RLRKVLDPGV LASESGGYAV RSLGEGALDL
SVAQELATEA EKARGTGDLC HARDVLNRVL SLWDGEALAG VPGPYAEAQR VRLEEWRLQL
LESRLDMDLE QGCHAEAVSE LTALTAAHPL RERLRELLML ALYRSGRQAE ALAVYADTRR
LLADELGVDP RPGLRELQQR ILQADPGLAE PSAPLAEPAV VPVRPAQLPA TVPDFTGRSS
FVTELSDVLA SAEGRVMAVS ALAGIGGVGK TTLAVHVAHQ ARSAFPDGQL YVDLQGAGSR
AADPETVLGS FLRALGTADS AIPDSLEERA ALYRSVLDGR RVLVLLDNAR DAAQVRPLLP
GTSGCAALVT SRVRMVDLAG AHLVDLDVMS PDEALSLFTK IVGEERVASE REAALDVVAA
CGFLPLAIRI AASRLAARRT WTVSVLAAKL GDERRRLDEL QAGDLAVKAT IELGYGQLEP
AQARAFRLLG LADGPDISLA AAAALLDLGV EETEELLESL VDTSLLESAA PGRYRFHDLV
RLYARACAER DEWPPSERGA ALSRLLDFYL ATTAQVYAIE HGEDRLIDHL EPTRYPGLRF
TEAPTALDWL YTEAGQLLAC VRQAAGTERL RRAVDLLWAA KDLTESGANS HQYEMTAKAT
CEATRVAGHE RAEGRARTVL SDVLLVSGRV REAEQEARVA MELAASARDS IAVSWVANNR
GLICLHESRF ADGKVFFDQA LEGLRATGNR PFEATVLGNL SRAHLGLGNI AKAVEIAQSG
LAVHTEVGRT VRLANGHFQL GVALTRAGRY TEALSQFSDA LGLFNDHRQR LWEGVTHFRT
AEVHAAEHRA AHAAQHAEQA LALGCIGGDR MRGNVLTLLG RSLSALGQAD RARACWREAL
NLYEQNSAPE AEEARALLTS AAAA
//
