ID K4RCT4_STRDJ Unreviewed; 526 AA.
AC K4RCT4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Nickel transporter {ECO:0008006|Google:ProtNLM};
GN ORFNames=BN159_6838 {ECO:0000313|EMBL:CCK31217.1};
OS Streptomyces davaonensis (strain DSM 101723 / JCM 4913 / KCC S-0913 / 768).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1214101 {ECO:0000313|EMBL:CCK31217.1, ECO:0000313|Proteomes:UP000008043};
RN [1] {ECO:0000313|EMBL:CCK31217.1, ECO:0000313|Proteomes:UP000008043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 101723 / JCM 4913 / KCC S-0913 / 768
RC {ECO:0000313|Proteomes:UP000008043};
RX PubMed=23043000; DOI=10.1128/JB.01592-12;
RA Jankowitsch F., Schwarz J., Ruckert C., Gust B., Szczepanowski R., Blom J.,
RA Pelzer S., Kalinowski J., Mack M.;
RT "Genome sequence of the bacterium Streptomyces davawensis JCM 4913 and
RT heterologous production of the unique antibiotic roseoflavin.";
RL J. Bacteriol. 194:6818-6827(2012).
CC -!- FUNCTION: Efflux system for nickel and cobalt.
CC {ECO:0000256|ARBA:ARBA00002510}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; HE971709; CCK31217.1; -; Genomic_DNA.
DR RefSeq; WP_015661551.1; NC_020504.1.
DR AlphaFoldDB; K4RCT4; -.
DR STRING; 1214101.BN159_6838; -.
DR KEGG; sdv:BN159_6838; -.
DR PATRIC; fig|1214101.3.peg.6927; -.
DR eggNOG; COG2215; Bacteria.
DR HOGENOM; CLU_030955_0_0_11; -.
DR OrthoDB; 271709at2; -.
DR Proteomes; UP000008043; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015099; F:nickel cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006824; P:cobalt ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR PANTHER; PTHR40659; NICKEL/COBALT EFFLUX SYSTEM RCNA; 1.
DR PANTHER; PTHR40659:SF1; NICKEL_COBALT EFFLUX SYSTEM RCNA; 1.
DR Pfam; PF03824; NicO; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Cobalt transport {ECO:0000256|ARBA:ARBA00022426};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nickel {ECO:0000256|ARBA:ARBA00022596};
KW Nickel transport {ECO:0000256|ARBA:ARBA00023112};
KW Reference proteome {ECO:0000313|Proteomes:UP000008043};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..526
FT /note="Nickel transporter"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003883735"
FT TRANSMEM 239..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 341..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 526 AA; 54210 MW; C8F3395729FD6A2A CRC64;
MTPRRLIASG AAVFAAVGAL VLVPSSVASA HPLGNFTVNR YDGLVVASGT LRVDHVEDLA
EIPATQAKPD IERLGLEQWA GRRCASAARD SELTVEGRSV ALTVKSSHAR VRPGQAGLDT
LRVECALRAP LPDSETLTLD FRAAGAESGP GWREVTARGD RMTLAESDVP KESLSGELTT
YPEELLSSPA DTASASLTVR PGGPALVEEE RDAPAASVLP RGADRWTRAL DSLVARNDLT
VGFAALALFI AIGLGALHAV APGHGKTLMA AVATARGGRA RMKDVLPLAA SVTVTHTLGV
VALGLLVTAG SAAAPSVITW LGIASGALVM AAGATLVRRA WHQRGHHHPH SPAPERTPTP
VLVGAHTHGH GHGHDHSHGH EHSHDHEHDH ERPKEHTHTH THGGTTHTHA TAPTIRGTIL
LGFAGGLVPS PSAVVVLVGA AALGHAWFGL LLVVAYGVGL ALTLTAAGYA VVRLGAGASR
WVERRPSWAV HPVAGLIRRT APLVSALVVV ALGAGLVLKG AASALG
//