ID K5B7V9_MYCHD Unreviewed; 405 AA.
AC K5B7V9;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=3-ketoacyl-CoA thiolase {ECO:0000313|EMBL:VCT91535.1};
DE EC=2.3.1.16 {ECO:0000313|EMBL:VCT91535.1};
DE SubName: Full=Acetyl-CoA C-acetyltransferase family protein {ECO:0000313|EMBL:EKF22628.1};
GN Name=fadA_8 {ECO:0000313|EMBL:VCT91535.1};
GN ORFNames=C731_3368 {ECO:0000313|EMBL:EKF22628.1}, MHAS_03250
GN {ECO:0000313|EMBL:VCT91535.1};
OS Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 /
OS 3849) (Mycobacterium hassiacum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1122247 {ECO:0000313|EMBL:EKF22628.1, ECO:0000313|Proteomes:UP000006265};
RN [1] {ECO:0000313|EMBL:EKF22628.1, ECO:0000313|Proteomes:UP000006265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 {ECO:0000313|EMBL:EKF22628.1}, and DSM 44199 / CIP
RC 105218 / JCM 12690 / 3849 {ECO:0000313|Proteomes:UP000006265};
RX PubMed=23209251; DOI=10.1128/JB.01880-12;
RA Tiago I., Maranha A., Mendes V., Alarico S., Moynihan P.J., Clarke A.J.,
RA Macedo-Ribeiro S., Pereira P.J., Empadinhas N.;
RT "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of
RT heat-stable mycobacterial proteins.";
RL J. Bacteriol. 194:7010-7011(2012).
RN [2] {ECO:0000313|EMBL:VCT91535.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mhassiacum {ECO:0000313|EMBL:VCT91535.1};
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000268660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 / CIP 105218 / JCM 12690 / 3849
RC {ECO:0000313|Proteomes:UP000268660};
RX PubMed=30701245; DOI=10.1128/mra.01522-18;
RA Sanchez M., Blesa A., Sacristan-Horcajada E., Berenguer J.;
RT "Complete genome sequence of Mycolicibacterium hassiacum DSM 44199.";
RL Microbiol. Resour. Announc. 8:e01522-e01522(2019).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; AMRA01000095; EKF22628.1; -; Genomic_DNA.
DR EMBL; LR026975; VCT91535.1; -; Genomic_DNA.
DR RefSeq; WP_005629554.1; NZ_LR026975.1.
DR AlphaFoldDB; K5B7V9; -.
DR STRING; 1122247.GCA_000379865_04228; -.
DR KEGG; mhas:MHAS_03250; -.
DR PATRIC; fig|1122247.3.peg.3231; -.
DR eggNOG; COG0183; Bacteria.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000006265; Unassembled WGS sequence.
DR Proteomes; UP000268660; Chromosome 1.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF8; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:VCT91535.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006265};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:EKF22628.1}.
FT DOMAIN 5..273
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 281..403
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 90
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 360
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 390
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 405 AA; 42974 MW; BA511424F482E793 CRC64;
MAEAVIVATA RSPIGRAHKG SLVDMRPDDL AAQMVRAVLD KVPALDPHDI DDLLMGCGQP
AGESGFNIAR TVAVQLGYDF LPGTTVNRYC SSSLQTTRMA FHAIKAGEGD VFISAGVETV
SRFGKGTADA WPDTKNPLFA DAMKRSEQAA AGADEWHDPR EDGLLPDVYI AMGQTAENVA
LYTGISREEQ DHWGVRSQNR AEEAIKNGFF EREITPVTLP DGTVVSKDDG PRFGTTHEKV
SQLKPVFRPN GTVTAGNACP LNDGAAALVV MSDTKAKKLG LTPLARIVAT GVSGLSPEIM
GLGPIEACRK ALAKAGMTIN DIDLYEINEA FAVQVLGSAR ELGMDLDRLN VSGGAIALGH
PFGMTGARIT ATLINNLQTY DKQFGLETMC VGGGQGMAMI IERLS
//
