ID K5B9F7_MYCHD Unreviewed; 918 AA.
AC K5B9F7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Bacterial regulatory s, luxR family protein {ECO:0000313|EMBL:EKF25368.1};
DE SubName: Full=HTH-type transcriptional regulator {ECO:0000313|EMBL:VCT93019.1};
GN ORFNames=C731_0605 {ECO:0000313|EMBL:EKF25368.1}, MHAS_04757
GN {ECO:0000313|EMBL:VCT93019.1};
OS Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 /
OS 3849) (Mycobacterium hassiacum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1122247 {ECO:0000313|EMBL:EKF25368.1, ECO:0000313|Proteomes:UP000006265};
RN [1] {ECO:0000313|EMBL:EKF25368.1, ECO:0000313|Proteomes:UP000006265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 {ECO:0000313|EMBL:EKF25368.1}, and DSM 44199 / CIP
RC 105218 / JCM 12690 / 3849 {ECO:0000313|Proteomes:UP000006265};
RX PubMed=23209251; DOI=10.1128/JB.01880-12;
RA Tiago I., Maranha A., Mendes V., Alarico S., Moynihan P.J., Clarke A.J.,
RA Macedo-Ribeiro S., Pereira P.J., Empadinhas N.;
RT "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of
RT heat-stable mycobacterial proteins.";
RL J. Bacteriol. 194:7010-7011(2012).
RN [2] {ECO:0000313|EMBL:VCT93019.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mhassiacum {ECO:0000313|EMBL:VCT93019.1};
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000268660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 / CIP 105218 / JCM 12690 / 3849
RC {ECO:0000313|Proteomes:UP000268660};
RX PubMed=30701245; DOI=10.1128/mra.01522-18;
RA Sanchez M., Blesa A., Sacristan-Horcajada E., Berenguer J.;
RT "Complete genome sequence of Mycolicibacterium hassiacum DSM 44199.";
RL Microbiol. Resour. Announc. 8:e01522-e01522(2019).
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DR EMBL; AMRA01000016; EKF25368.1; -; Genomic_DNA.
DR EMBL; LR026975; VCT93019.1; -; Genomic_DNA.
DR RefSeq; WP_005624427.1; NZ_LR026975.1.
DR AlphaFoldDB; K5B9F7; -.
DR STRING; 1122247.GCA_000379865_01549; -.
DR KEGG; mhas:MHAS_04757; -.
DR PATRIC; fig|1122247.3.peg.581; -.
DR eggNOG; COG2909; Bacteria.
DR OrthoDB; 3796539at2; -.
DR Proteomes; UP000006265; Unassembled WGS sequence.
DR Proteomes; UP000268660; Chromosome 1.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00196; GerE; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006265}.
FT DOMAIN 848..913
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
SQ SEQUENCE 918 AA; 99007 MW; 6E1843DAE3743EFE CRC64;
MSRTIDRPGQ AEVVEDFLAA ARSGSAALII EGEAGIGKTT VWLSATEVAA RRGFQVLVAR
PSAAESVLAY GSLADMLGGV DPGMWEHLPA PQRAALERVL LRADGTGPVD QRAVAAGFRS
VVDALAGAGP VLLAIDDLQW LDTSSRLVIE FAARRMPAGV GLLATLRTDP SAPANASWVQ
LRDPQAVRRM VLPPFGLASL RELLLARLGR SFSRAALVRI HEIARGNPFY ALELARATTD
DRIVRLPDSL AELVRARIDR LSEEARTALL AVSCSSTPTV ERVARATESH PEAVIGVLAE
AIDDGIVSVE GHQIRFTHPL LAHGVHDGAS FALRRSMHRR LAGIETEPEL RARHLAMAAV
SGDPDTLACL DAAAQSARRR GAPAAAAELA DLAIGLGGDT PQRRIVSARN HFDAGDGERA
RKVLKHGLAA LEAGPERAEM LSLLGAIEAL DGSYLDAAQL LQRAIDEVGD EPASRARFLV
LQAFARLNIG RRDTAAADVD EAVACAIRCG NAHLLSQALA MQCLMDCVRG RDFDPAKMRR
ALELEDPGAE CLALTRPKNL HAMVLAYTGQ LDEAARATRG IAEDCADRGE EVDQLFSYFH
RVLVEIWRGD LHAADEIGSE AIELAQMLDG GVTRGVGLML QHFLACYRGE VERARRLGSE
ALTALEPSYC GILINLVVTL NGFLEVSQGN YPQAVDVLEP LLAQLDPDLN GTEIIVGWFL
PDLAEALIHS GRGGDAEPLV AALERNGRRL DRAWMTAVGG RCRAMLLAAG GDVDAAVRTA
EEAMRAHDRT PMRFERARTL LVLGQLQRRR RRRDAATVAL REALDAFERI GTPLWAERAR
AELHRGELGA GFAGLSETER RVAELSAAGM TNRDVAATLF ISPKTVETYL GRIYRKLGIH
SRAELGRLMA EQHQPDDK
//
