ID K5BBY7_MYCHD Unreviewed; 432 AA.
AC K5BBY7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Pyrimidine-nucleoside phosphorylase family protein {ECO:0000313|EMBL:EKF24735.1};
DE EC=2.4.2.2 {ECO:0000313|EMBL:EKF24735.1};
DE SubName: Full=Thymidine phosphorylase {ECO:0000313|EMBL:VCT88755.1};
DE EC=2.4.2.4 {ECO:0000313|EMBL:VCT88755.1};
GN Name=pdp {ECO:0000313|EMBL:EKF24735.1};
GN Synonyms=deoA {ECO:0000313|EMBL:VCT88755.1};
GN ORFNames=C731_1270 {ECO:0000313|EMBL:EKF24735.1}, MHAS_00439
GN {ECO:0000313|EMBL:VCT88755.1};
OS Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 /
OS 3849) (Mycobacterium hassiacum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1122247 {ECO:0000313|EMBL:EKF24735.1, ECO:0000313|Proteomes:UP000006265};
RN [1] {ECO:0000313|EMBL:EKF24735.1, ECO:0000313|Proteomes:UP000006265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 {ECO:0000313|EMBL:EKF24735.1}, and DSM 44199 / CIP
RC 105218 / JCM 12690 / 3849 {ECO:0000313|Proteomes:UP000006265};
RX PubMed=23209251; DOI=10.1128/JB.01880-12;
RA Tiago I., Maranha A., Mendes V., Alarico S., Moynihan P.J., Clarke A.J.,
RA Macedo-Ribeiro S., Pereira P.J., Empadinhas N.;
RT "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of
RT heat-stable mycobacterial proteins.";
RL J. Bacteriol. 194:7010-7011(2012).
RN [2] {ECO:0000313|EMBL:VCT88755.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mhassiacum {ECO:0000313|EMBL:VCT88755.1};
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000268660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 / CIP 105218 / JCM 12690 / 3849
RC {ECO:0000313|Proteomes:UP000268660};
RX PubMed=30701245; DOI=10.1128/mra.01522-18;
RA Sanchez M., Blesa A., Sacristan-Horcajada E., Berenguer J.;
RT "Complete genome sequence of Mycolicibacterium hassiacum DSM 44199.";
RL Microbiol. Resour. Announc. 8:e01522-e01522(2019).
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC phosphorylase family. {ECO:0000256|ARBA:ARBA00006915}.
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DR EMBL; AMRA01000032; EKF24735.1; -; Genomic_DNA.
DR EMBL; LR026975; VCT88755.1; -; Genomic_DNA.
DR RefSeq; WP_005625741.1; NZ_LR026975.1.
DR AlphaFoldDB; K5BBY7; -.
DR STRING; 1122247.GCA_000379865_02255; -.
DR KEGG; mhas:MHAS_00439; -.
DR PATRIC; fig|1122247.3.peg.1222; -.
DR eggNOG; COG0213; Bacteria.
DR OrthoDB; 9763887at2; -.
DR Proteomes; UP000006265; Unassembled WGS sequence.
DR Proteomes; UP000268660; Chromosome 1.
DR GO; GO:0004645; F:1,4-alpha-oligoglucan phosphorylase activity; IEA:InterPro.
DR GO; GO:0016154; F:pyrimidine-nucleoside phosphorylase activity; IEA:UniProtKB-EC.
DR GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR GO; GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro.
DR Gene3D; 3.40.1030.10; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR Gene3D; 3.90.1170.30; Pyrimidine nucleoside phosphorylase-like, C-terminal domain; 1.
DR InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom.
DR InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom_sf.
DR InterPro; IPR035902; Nuc_phospho_transferase.
DR InterPro; IPR036566; PYNP-like_C_sf.
DR InterPro; IPR013102; PYNP_C.
DR InterPro; IPR018090; Pyrmidine_PPas_bac/euk.
DR InterPro; IPR017872; Pyrmidine_PPase_CS.
DR InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR NCBIfam; TIGR02644; Y_phosphoryl; 1.
DR PANTHER; PTHR10515; THYMIDINE PHOSPHORYLASE; 1.
DR PANTHER; PTHR10515:SF0; THYMIDINE PHOSPHORYLASE; 1.
DR Pfam; PF02885; Glycos_trans_3N; 1.
DR Pfam; PF00591; Glycos_transf_3; 1.
DR Pfam; PF07831; PYNP_C; 1.
DR PIRSF; PIRSF000478; TP_PyNP; 1.
DR SMART; SM00941; PYNP_C; 1.
DR SUPFAM; SSF52418; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR SUPFAM; SSF47648; Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain; 1.
DR SUPFAM; SSF54680; Pyrimidine nucleoside phosphorylase C-terminal domain; 1.
DR PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:EKF24735.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006265};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EKF24735.1}.
FT DOMAIN 343..417
FT /note="Pyrimidine nucleoside phosphorylase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00941"
SQ SEQUENCE 432 AA; 45362 MW; AB0462CCD60E9CDA CRC64;
MTRFTFDAPT VIRIKRDGGA LPDVAIDWVI DAYTHGRVAD EQMSALLMAI FLRGMTDAEI
ARWTAAMVDS GARLDFTDLR RDGKPLALVD KHSTGGVGDK ITIPLVPVVM ACGGAVPQAA
GRGLGHTGGT LDKLEAIPGF SAELTIDRIR EQLCDIGAAV FAAGELAPAD RKIYALRDIT
ATTESLPLIA SSVMSKKIAE GTRALVLDCK VGSGAFLKTE AESRELARTM VRLGTAHGLR
TRALLTDMST PLGRAVGNAV EVAESLEVLA GGGPDDVVEL TLALAHEMLD AAGLDGVDPA
DTLRDGTAMD RFRALVAAQG GDLSRPLPVG RCRETVTAPE SGVVQDIDAL AVGMAVWRLG
AGRSAPGEQV QFGAGLHIHR RPGEPVTAGE PVLTLYTDIP ERFEAAVAEL DGAIRIGHTA
APPRPLVIDR IV
//
