ID K5BIG2_MYCHD Unreviewed; 325 AA.
AC K5BIG2;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:EKF21309.1};
DE SubName: Full=Phthiocerol/phenolphthiocerol synthesis polyketide synthase type I PpsC {ECO:0000313|EMBL:VCT92331.1};
DE EC=2.3.1.41 {ECO:0000313|EMBL:VCT92331.1};
GN Name=ppsC_2 {ECO:0000313|EMBL:VCT92331.1};
GN ORFNames=C731_4725 {ECO:0000313|EMBL:EKF21309.1}, MHAS_04058
GN {ECO:0000313|EMBL:VCT92331.1};
OS Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 /
OS 3849) (Mycobacterium hassiacum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1122247 {ECO:0000313|EMBL:EKF21309.1, ECO:0000313|Proteomes:UP000006265};
RN [1] {ECO:0000313|EMBL:EKF21309.1, ECO:0000313|Proteomes:UP000006265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 {ECO:0000313|EMBL:EKF21309.1}, and DSM 44199 / CIP
RC 105218 / JCM 12690 / 3849 {ECO:0000313|Proteomes:UP000006265};
RX PubMed=23209251; DOI=10.1128/JB.01880-12;
RA Tiago I., Maranha A., Mendes V., Alarico S., Moynihan P.J., Clarke A.J.,
RA Macedo-Ribeiro S., Pereira P.J., Empadinhas N.;
RT "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of
RT heat-stable mycobacterial proteins.";
RL J. Bacteriol. 194:7010-7011(2012).
RN [2] {ECO:0000313|EMBL:VCT92331.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mhassiacum {ECO:0000313|EMBL:VCT92331.1};
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000268660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 / CIP 105218 / JCM 12690 / 3849
RC {ECO:0000313|Proteomes:UP000268660};
RX PubMed=30701245; DOI=10.1128/mra.01522-18;
RA Sanchez M., Blesa A., Sacristan-Horcajada E., Berenguer J.;
RT "Complete genome sequence of Mycolicibacterium hassiacum DSM 44199.";
RL Microbiol. Resour. Announc. 8:e01522-e01522(2019).
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DR EMBL; AMRA01000150; EKF21309.1; -; Genomic_DNA.
DR EMBL; LR026975; VCT92331.1; -; Genomic_DNA.
DR RefSeq; WP_005632357.1; NZ_LR026975.1.
DR AlphaFoldDB; K5BIG2; -.
DR STRING; 1122247.GCA_000379865_03604; -.
DR KEGG; mhas:MHAS_04058; -.
DR PATRIC; fig|1122247.3.peg.4524; -.
DR eggNOG; COG0604; Bacteria.
DR OrthoDB; 9787435at2; -.
DR Proteomes; UP000006265; Unassembled WGS sequence.
DR Proteomes; UP000268660; Chromosome 1.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR44154; QUINONE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR44154:SF1; QUINONE OXIDOREDUCTASE; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:VCT92331.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006265};
KW Transferase {ECO:0000313|EMBL:VCT92331.1}.
FT DOMAIN 10..323
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 325 AA; 34084 MW; 0C25F37511A266B2 CRC64;
MKAVVLEAFG GPEVLVSRAV PEPPQRRGWV TVALRASALN WHDVLVRQGR YGSPLPHIPG
ADGAGVRVDT GEEVVILPSL FWGADSAAPA PEFEILGDRV AGTYAEYVSV PEECVAPKPA
GLSWAEAAAL PLVGVTCYRA LVTRAGLRTG ESLLIIGAGG GIATMALSLG AALGARVWVT
ASTDAKRDRA IAAGAQGGVL HSDADWPQRA REISPDGRGF DVILDAVGLW GRSVQALRPG
GRLVVLGANV AERADMDIRA FYFGQYSLLG TTMGSPSDFR GLLDLVAKGR LSRPVIARTF
PLADAAEAHR HLESGGEFGK IVLLQ
//
