ID K5BIQ6_MYCHD Unreviewed; 490 AA.
AC K5BIQ6;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=AMP-binding enzyme family protein {ECO:0000313|EMBL:EKF21779.1};
DE SubName: Full=Long-chain-fatty-acid--CoA ligase {ECO:0000313|EMBL:VCT92541.1};
DE EC=6.2.1.3 {ECO:0000313|EMBL:VCT92541.1};
GN Name=lcfB_17 {ECO:0000313|EMBL:VCT92541.1};
GN ORFNames=C731_4263 {ECO:0000313|EMBL:EKF21779.1}, MHAS_04271
GN {ECO:0000313|EMBL:VCT92541.1};
OS Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 /
OS 3849) (Mycobacterium hassiacum).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1122247 {ECO:0000313|EMBL:EKF21779.1, ECO:0000313|Proteomes:UP000006265};
RN [1] {ECO:0000313|EMBL:EKF21779.1, ECO:0000313|Proteomes:UP000006265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 {ECO:0000313|EMBL:EKF21779.1}, and DSM 44199 / CIP
RC 105218 / JCM 12690 / 3849 {ECO:0000313|Proteomes:UP000006265};
RX PubMed=23209251; DOI=10.1128/JB.01880-12;
RA Tiago I., Maranha A., Mendes V., Alarico S., Moynihan P.J., Clarke A.J.,
RA Macedo-Ribeiro S., Pereira P.J., Empadinhas N.;
RT "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of
RT heat-stable mycobacterial proteins.";
RL J. Bacteriol. 194:7010-7011(2012).
RN [2] {ECO:0000313|EMBL:VCT92541.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mhassiacum {ECO:0000313|EMBL:VCT92541.1};
RA Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA Castillo E.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000268660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 / CIP 105218 / JCM 12690 / 3849
RC {ECO:0000313|Proteomes:UP000268660};
RX PubMed=30701245; DOI=10.1128/mra.01522-18;
RA Sanchez M., Blesa A., Sacristan-Horcajada E., Berenguer J.;
RT "Complete genome sequence of Mycolicibacterium hassiacum DSM 44199.";
RL Microbiol. Resour. Announc. 8:e01522-e01522(2019).
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DR EMBL; AMRA01000114; EKF21779.1; -; Genomic_DNA.
DR EMBL; LR026975; VCT92541.1; -; Genomic_DNA.
DR RefSeq; WP_005631337.1; NZ_LR026975.1.
DR AlphaFoldDB; K5BIQ6; -.
DR STRING; 1122247.GCA_000379865_00807; -.
DR KEGG; mhas:MHAS_04271; -.
DR PATRIC; fig|1122247.3.peg.4091; -.
DR eggNOG; COG0318; Bacteria.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000006265; Unassembled WGS sequence.
DR Proteomes; UP000268660; Chromosome 1.
DR GO; GO:0004467; F:long-chain fatty acid-CoA ligase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:VCT92541.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006265}.
FT DOMAIN 13..349
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 399..474
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 490 AA; 51383 MW; A9697402BCB06E13 CRC64;
MSPSLESLSS LPDRRAASDP AAPCLADDAV TLNNAEFRAA VESAAAVLHG HGVGAGDVVA
VMLPNTVDLV VTLFAAWRLG AAVTPLNPAL SADEAGYQLT DAGAKVLVTA GATAAPVPVV
APGELKHGAG PAPAVPGSAE RLALLIYTSG TTGRPKGVML DHANVTAMCA AIIEAYELSP
ADSSLLILPL FHVNGIVVGT LSPLLAGGHV TIAGRFETRS FFERVRRCRP TYFSAVPTIY
TRLVELPEDV EVDTSSLRFA VCGAAPASAE LLERFERRFG VPIVEGYGLS EGTCASTANP
LRGPRKPGTV GIPLPGQRVR IADGQGRTLG PNEIGEVLIA GPTVMRGYLN RPEETAKTIV
DGWLHTGDIG YLDADGYLVL VDRAKDMIIR GGENIYPKEI ETVAYRLPEI AEAAVIGRPH
PVYGEVPVMY LAPAPGHPID TDAVRRHLAA SLAKYKQPVE ITVLDALPKN AVGKIDKPAI
RRLDAAARTA
//
