UniProt: K5BK12

Database: UniProt
Entry: K5BK12_MYCHD

LinkDB:  K5BK12_MYCHD 
Original site:  K5BK12_MYCHD

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Ontology (7)   
   GO (7)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (9)   
   InterPro (6)   
   Pfam (2)   
   SMART (1)   
Literature (2)   
   PubMed (2)   
All databases (24)   

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ID   K5BK12_MYCHD            Unreviewed;       326 AA.
AC   K5BK12;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=Riboflavin biosynthesis protein {ECO:0000256|PIRNR:PIRNR004491};
DE   Includes:
DE     RecName: Full=Riboflavin kinase {ECO:0000256|PIRNR:PIRNR004491};
DE              EC=2.7.1.26 {ECO:0000256|PIRNR:PIRNR004491};
DE     AltName: Full=Flavokinase {ECO:0000256|PIRNR:PIRNR004491};
DE   Includes:
DE     RecName: Full=FMN adenylyltransferase {ECO:0000256|PIRNR:PIRNR004491};
DE              EC=2.7.7.2 {ECO:0000256|PIRNR:PIRNR004491};
DE     AltName: Full=FAD pyrophosphorylase {ECO:0000256|PIRNR:PIRNR004491};
DE     AltName: Full=FAD synthase {ECO:0000256|PIRNR:PIRNR004491};
GN   Name=ribF {ECO:0000313|EMBL:EKF24059.1};
GN   ORFNames=C731_1819 {ECO:0000313|EMBL:EKF24059.1}, MHAS_02410
GN   {ECO:0000313|EMBL:VCT90701.1};
OS   Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 /
OS   3849) (Mycobacterium hassiacum).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=1122247 {ECO:0000313|EMBL:EKF24059.1, ECO:0000313|Proteomes:UP000006265};
RN   [1] {ECO:0000313|EMBL:EKF24059.1, ECO:0000313|Proteomes:UP000006265}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44199 {ECO:0000313|EMBL:EKF24059.1}, and DSM 44199 / CIP
RC   105218 / JCM 12690 / 3849 {ECO:0000313|Proteomes:UP000006265};
RX   PubMed=23209251; DOI=10.1128/JB.01880-12;
RA   Tiago I., Maranha A., Mendes V., Alarico S., Moynihan P.J., Clarke A.J.,
RA   Macedo-Ribeiro S., Pereira P.J., Empadinhas N.;
RT   "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of
RT   heat-stable mycobacterial proteins.";
RL   J. Bacteriol. 194:7010-7011(2012).
RN   [2] {ECO:0000313|EMBL:VCT90701.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mhassiacum {ECO:0000313|EMBL:VCT90701.1};
RA   Peiro R., Begona, Cbmso G., Lopez M., Gonzalez S., Sacristan E.,
RA   Castillo E.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000268660}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44199 / CIP 105218 / JCM 12690 / 3849
RC   {ECO:0000313|Proteomes:UP000268660};
RX   PubMed=30701245; DOI=10.1128/mra.01522-18;
RA   Sanchez M., Blesa A., Sacristan-Horcajada E., Berenguer J.;
RT   "Complete genome sequence of Mycolicibacterium hassiacum DSM 44199.";
RL   Microbiol. Resour. Announc. 8:e01522-e01522(2019).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + FMN + H(+) = diphosphate + FAD; Xref=Rhea:RHEA:17237,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57692, ChEBI:CHEBI:58210; EC=2.7.7.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001332,
CC         ECO:0000256|PIRNR:PIRNR004491};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + riboflavin = ADP + FMN + H(+); Xref=Rhea:RHEA:14357,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57986,
CC         ChEBI:CHEBI:58210, ChEBI:CHEBI:456216; EC=2.7.1.26;
CC         Evidence={ECO:0000256|ARBA:ARBA00000372,
CC         ECO:0000256|PIRNR:PIRNR004491};
CC   -!- PATHWAY: Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step
CC       1/1. {ECO:0000256|ARBA:ARBA00004726, ECO:0000256|PIRNR:PIRNR004491}.
CC   -!- PATHWAY: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin
CC       (ATP route): step 1/1. {ECO:0000256|ARBA:ARBA00005201,
CC       ECO:0000256|PIRNR:PIRNR004491}.
CC   -!- SIMILARITY: Belongs to the ribF family.
CC       {ECO:0000256|PIRNR:PIRNR004491}.
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DR   EMBL; AMRA01000046; EKF24059.1; -; Genomic_DNA.
DR   EMBL; LR026975; VCT90701.1; -; Genomic_DNA.
DR   RefSeq; WP_005626742.1; NZ_LR026975.1.
DR   AlphaFoldDB; K5BK12; -.
DR   STRING; 1122247.GCA_000379865_04827; -.
DR   KEGG; mhas:MHAS_02410; -.
DR   PATRIC; fig|1122247.3.peg.1750; -.
DR   eggNOG; COG0196; Bacteria.
DR   OrthoDB; 9803667at2; -.
DR   UniPathway; UPA00276; UER00406.
DR   UniPathway; UPA00277; UER00407.
DR   Proteomes; UP000006265; Unassembled WGS sequence.
DR   Proteomes; UP000268660; Chromosome 1.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003919; F:FMN adenylyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008531; F:riboflavin kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006747; P:FAD biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009398; P:FMN biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0009231; P:riboflavin biosynthetic process; IEA:InterPro.
DR   CDD; cd02064; FAD_synthetase_N; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   Gene3D; 2.40.30.30; Riboflavin kinase-like; 1.
DR   InterPro; IPR015864; FAD_synthase.
DR   InterPro; IPR023468; Riboflavin_kinase.
DR   InterPro; IPR002606; Riboflavin_kinase_bac.
DR   InterPro; IPR015865; Riboflavin_kinase_bac/euk.
DR   InterPro; IPR023465; Riboflavin_kinase_dom_sf.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   NCBIfam; TIGR00083; ribF; 1.
DR   PANTHER; PTHR22749:SF6; RIBOFLAVIN KINASE; 1.
DR   PANTHER; PTHR22749; RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE; 1.
DR   Pfam; PF06574; FAD_syn; 1.
DR   Pfam; PF01687; Flavokinase; 1.
DR   PIRSF; PIRSF004491; FAD_Synth; 1.
DR   SMART; SM00904; Flavokinase; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF82114; Riboflavin kinase-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR004491};
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRNR:PIRNR004491};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|PIRNR:PIRNR004491};
KW   FMN {ECO:0000256|ARBA:ARBA00022643, ECO:0000256|PIRNR:PIRNR004491};
KW   Kinase {ECO:0000256|PIRNR:PIRNR004491};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRNR:PIRNR004491};
KW   Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR004491};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006265};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR004491}.
FT   DOMAIN          187..322
FT                   /note="Riboflavin kinase"
FT                   /evidence="ECO:0000259|SMART:SM00904"
SQ   SEQUENCE   326 AA;  35695 MW;  C25714FDBC74E248 CRC64;
     MQRWRGQDDI PTDWGRCVVT IGVFDGVHRG HQELISHAVK SGRARGVPTV LMTFDPHPME
     VVFPGSHPAQ LTTLARRAEL VEELGIDVFL VMPFTADFMK LSPERYIHEL LVERLHVVEV
     VVGENFTFGK KAAGNVELLR KAGERFGFHV EAMSLVVEQH GEEVVTFSST YIRSCVDAGD
     VVAAAEALGR PHRVEGVVVR GDGRGRGLGF PTANIAPPMY SAIPADGIYA AWFTVLGHGE
     GAGELVPGER YQAAVSVGTN PTFSGRTRTV EAYVLDVSAD LYGQHVAVDF VARLRGQQKF
     DRVEDLVEQM HADTERTRAV LAADRP
//

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