ID K5UXV0_PHACS Unreviewed; 602 AA.
AC K5UXV0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=tyrosinase {ECO:0000256|ARBA:ARBA00011906};
DE EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
GN ORFNames=PHACADRAFT_259085 {ECO:0000313|EMBL:EKM54921.1};
OS Phanerochaete carnosa (strain HHB-10118-sp) (White-rot fungus) (Peniophora
OS carnosa).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Phanerochaetaceae; Phanerochaete.
OX NCBI_TaxID=650164 {ECO:0000313|EMBL:EKM54921.1, ECO:0000313|Proteomes:UP000008370};
RN [1] {ECO:0000313|EMBL:EKM54921.1, ECO:0000313|Proteomes:UP000008370}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB-10118-sp {ECO:0000313|EMBL:EKM54921.1,
RC ECO:0000313|Proteomes:UP000008370};
RX PubMed=22937793; DOI=10.1186/1471-2164-13-444;
RA Suzuki H., MacDonald J., Syed K., Salamov A., Hori C., Aerts A.,
RA Henrissat B., Wiebenga A., vanKuyk P.A., Barry K., Lindquist E.,
RA LaButti K., Lapidus A., Lucas S., Coutinho P., Gong Y., Samejima M.,
RA Mahadevan R., Abou-Zaid M., de Vries R.P., Igarashi K., Yadav J.S.,
RA Grigoriev I.V., Master E.R.;
RT "Comparative genomics of the white-rot fungi, Phanerochaete carnosa and P.
RT chrysosporium, to elucidate the genetic basis of the distinct wood types
RT they colonize.";
RL BMC Genomics 13:444-444(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 L-dopa + O2 = 2 H2O + 2 L-dopaquinone; Xref=Rhea:RHEA:34287,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57504,
CC ChEBI:CHEBI:57924; EC=1.14.18.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000426};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-tyrosine + O2 = H2O + L-dopaquinone; Xref=Rhea:RHEA:18117,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:57924,
CC ChEBI:CHEBI:58315; EC=1.14.18.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001038};
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- SIMILARITY: Belongs to the tyrosinase family.
CC {ECO:0000256|ARBA:ARBA00009928}.
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DR EMBL; JH930473; EKM54921.1; -; Genomic_DNA.
DR RefSeq; XP_007397593.1; XM_007397531.1.
DR AlphaFoldDB; K5UXV0; -.
DR STRING; 650164.K5UXV0; -.
DR GeneID; 18917302; -.
DR KEGG; pco:PHACADRAFT_259085; -.
DR HOGENOM; CLU_013691_3_0_1; -.
DR InParanoid; K5UXV0; -.
DR OrthoDB; 2785948at2759; -.
DR Proteomes; UP000008370; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004503; F:tyrosinase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.60.310.20; -; 1.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR016216; Monophenol_mOase_fun.
DR InterPro; IPR041640; Tyrosinase_C.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF76; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF18132; Tyosinase_C; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PIRSF; PIRSF000340; MPO_fungal; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00497; TYROSINASE_1; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 3: Inferred from homology;
KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008370}.
FT DOMAIN 90..107
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
FT DOMAIN 283..294
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
SQ SEQUENCE 602 AA; 64760 MW; 27FE3326AB7348D4 CRC64;
MSHFVITGVQ GGSTADAGPP NRLEINDFVK IEDQFSLYIQ ALTAMSQDTQ GDLTSFFQIG
AIHGLPYIQW DGSGGKEPVK NSQWGGYCTH GSVLFPTWHR PYVALFEQVL QQHAATIAKT
YTVDQDRWNK AAADLRAPYW DWAVNSVPPP EVIADKQVTI TLPDGTRGAV NNPLYGYVFH
PIDPSFPAPY NQWQSTLRHP ASDGPDAQTD VQALTDQLQS SQDDITSSTY RLLTRVHTWP
AFSNHSTDDG GSASNSLEAI HDGIHVDVGG DGQMADPSVA GFDPIFFLHH ANVDRMLSLW
SALNPGVWTT NGPAEGGTYT ITSNATVGPT TQLTPFWESQ SGYWLSSQTT ATGKLGYTYP
EFNGLNVSDP RAVKAAIAKA VNSLYGGPSF GAFAAAAPGI AAFAAPAAIH ATPAVSKLAA
PRNPQPSAES APNSVSDAAS SLYDWAVRIH VKKYELSGSF SVLIFLGPVP EDPREWRRSP
SFVGAHHAFV NSSASQCANC HNQAAAGYVT EGFVHLNTAI ARLSEIHSFE PSVVEPYLKR
ELSWRVVRAN KTAVDLNDVP SLEVVVCATQ LTLQPGADLP EHGTPQYFTG ITAGRQGGAR
TE
//
