ID K5W515_PHACS Unreviewed; 1005 AA.
AC K5W515;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 22-FEB-2023, entry version 45.
DE RecName: Full=chitin synthase {ECO:0000256|ARBA:ARBA00012543};
DE EC=2.4.1.16 {ECO:0000256|ARBA:ARBA00012543};
GN ORFNames=PHACADRAFT_257626 {ECO:0000313|EMBL:EKM54034.1};
OS Phanerochaete carnosa (strain HHB-10118-sp) (White-rot fungus) (Peniophora
OS carnosa).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Phanerochaetaceae; Phanerochaete.
OX NCBI_TaxID=650164 {ECO:0000313|EMBL:EKM54034.1, ECO:0000313|Proteomes:UP000008370};
RN [1] {ECO:0000313|EMBL:EKM54034.1, ECO:0000313|Proteomes:UP000008370}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HHB-10118-sp {ECO:0000313|EMBL:EKM54034.1,
RC ECO:0000313|Proteomes:UP000008370};
RX PubMed=22937793; DOI=10.1186/1471-2164-13-444;
RA Suzuki H., MacDonald J., Syed K., Salamov A., Hori C., Aerts A.,
RA Henrissat B., Wiebenga A., vanKuyk P.A., Barry K., Lindquist E.,
RA LaButti K., Lapidus A., Lucas S., Coutinho P., Gong Y., Samejima M.,
RA Mahadevan R., Abou-Zaid M., de Vries R.P., Igarashi K., Yadav J.S.,
RA Grigoriev I.V., Master E.R.;
RT "Comparative genomics of the white-rot fungi, Phanerochaete carnosa and P.
RT chrysosporium, to elucidate the genetic basis of the distinct wood types
RT they colonize.";
RL BMC Genomics 13:444-444(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-
CC D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) +
CC UDP; Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:58223; EC=2.4.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000319};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; JH930473; EKM54034.1; -; Genomic_DNA.
DR RefSeq; XP_007396739.1; XM_007396677.1.
DR AlphaFoldDB; K5W515; -.
DR STRING; 650164.K5W515; -.
DR GeneID; 18916902; -.
DR KEGG; pco:PHACADRAFT_257626; -.
DR HOGENOM; CLU_002572_0_0_1; -.
DR InParanoid; K5W515; -.
DR OrthoDB; 1331060at2759; -.
DR Proteomes; UP000008370; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004100; F:chitin synthase activity; IEA:UniProtKB-EC.
DR CDD; cd04190; Chitin_synth_C; 1.
DR InterPro; IPR004835; Chitin_synth.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22914; CHITIN SYNTHASE; 1.
DR PANTHER; PTHR22914:SF26; CHITIN SYNTHASE 7; 1.
DR Pfam; PF03142; Chitin_synth_2; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008370};
KW Transferase {ECO:0000313|EMBL:EKM54034.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 218..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 699..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 885..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 110491 MW; 76FEF0BF7FE7CC40 CRC64;
MCTFIGFLTV GFQKVLCPGS AQTAGKFVRV GTRPDTLGVQ GWLVNVTKTP QVNGVNFGTL
LESPGQDITT LFQRDASSYP ACNGLSFRAA AEAPCGNNAC TLPTLNQQTL SSLNMVNTSL
IVGYDWSDVA QLQNYLVLDG AVLDMNSYMA LHPTPIPSDS VDAAIRQILT QMPGDSGRDG
TRLFFFYPET RAAVPCLIQR YYAGNIDKIT PGCFASQLIL YAGLIVILSL VMVRFVMSCI
FSWFISARLA GPPDTMSLNR SAISPAVMPE GANMSIDNPN GTAPWASGKK LTVPSKSMRS
LASSNSTLLN DGTAPIVSLA QIGAELFAVC LVTCYSEGED SLRTTLDSIS TTTYSDARKL
LFVVADGMIT GAGEKKSTPD ICVSVLEADP RFGNPVPMSY NAVGAGVKAE NRAMVYAGHY
TVAGRRTPTI IVVKCGTERE AATDKKPGNR GKRDSQLILM NFFSRVTYND RMTPLDFDLF
RKIHILMGVT PDFFEVCLMV DADTKVAPDS LKYLVNCMHH DQMIMGVCGE TRIANKRQSW
VTAIQVFEYF ISHHMAKAFE SVFGGVSCLP GCFSMFRLKA RKSTGEDWVP LIIKPEIVKE
YSQSIVTTLH EKNLLLLGED RFLTTILLRT FPNRKMMFLP QARCRTVVPD TFKILLSQRR
RWINSTIHNL MELVLVRNLC GTFCFSMQFV VFMDLLGTVV LPIAITLTYS LIINMALDPP
KTFEEAIPLV LLIAVLGLPA VLILITTRKV VYVFWMLIYL AALPVWNLIL PVYAFWHFDD
FSWGETRKVE GEAKGEAHGD GGAAHSGPSI PLRRWEDWER SRLRKLRREE RRRREFERQH
GSYMTANGEL LTVRSPVHSQ YGGSDTISVT SSEDEHWAAQ IGGYNENSAS YPPPPIGLMP
QASVSGESVS ASELESMLEH GYDDRPQYRG ASQTPSPQRY QLSDRPGEYT PLSRTAASSP
VSSTGPVDGL SSAAEPYRTH VKKRSGGGSG AKYGPLGPLD PGSRI
//
