ID K5WWT3_AGABU Unreviewed; 414 AA.
AC K5WWT3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=G-protein alpha subunit {ECO:0008006|Google:ProtNLM};
GN ORFNames=AGABI1DRAFT_132402 {ECO:0000313|EMBL:EKM75263.1};
OS Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC
OS 10392) (White button mushroom).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Agaricus.
OX NCBI_TaxID=597362 {ECO:0000313|EMBL:EKM75263.1, ECO:0000313|Proteomes:UP000008493};
RN [1] {ECO:0000313|Proteomes:UP000008493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB137-S8 / ATCC MYA-4627 / FGSC 10392
RC {ECO:0000313|Proteomes:UP000008493};
RX PubMed=23045686; DOI=10.1073/pnas.1206847109;
RA Morin E., Kohler A., Baker A.R., Foulongne-Oriol M., Lombard V., Nagy L.G.,
RA Ohm R.A., Patyshakuliyeva A., Brun A., Aerts A.L., Bailey A.M.,
RA Billette C., Coutinho P.M., Deakin G., Doddapaneni H., Floudas D.,
RA Grimwood J., Hilden K., Kuees U., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lucas S.M., Murat C., Riley R.W., Salamov A.A., Schmutz J., Subramanian V.,
RA Woesten H.A.B., Xu J., Eastwood D.C., Foster G.D., Sonnenberg A.S.,
RA Cullen D., de Vries R.P., Lundell T., Hibbett D.S., Henrissat B.,
RA Burton K.S., Kerrigan R.W., Challen M.P., Grigoriev I.V., Martin F.;
RT "Genome sequence of the button mushroom Agaricus bisporus reveals
RT mechanisms governing adaptation to a humic-rich ecological niche.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:17501-17506(2012).
CC -!- SIMILARITY: Belongs to the G-alpha family.
CC {ECO:0000256|ARBA:ARBA00005804}.
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DR EMBL; JH971416; EKM75263.1; -; Genomic_DNA.
DR RefSeq; XP_007334084.1; XM_007334022.1.
DR AlphaFoldDB; K5WWT3; -.
DR STRING; 597362.K5WWT3; -.
DR GeneID; 18827664; -.
DR KEGG; abp:AGABI1DRAFT132402; -.
DR eggNOG; KOG0082; Eukaryota.
DR HOGENOM; CLU_014184_1_1_1; -.
DR InParanoid; K5WWT3; -.
DR OMA; WRPIVYF; -.
DR OrthoDB; 1864818at2759; -.
DR Proteomes; UP000008493; Unassembled WGS sequence.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF302; GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-8 SUBUNIT-RELATED; 1.
DR Pfam; PF00503; G-alpha; 2.
DR PRINTS; PR00318; GPROTEINA.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008493};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 46760 MW; 6CC4D70E3D64A348 CRC64;
MTRRASINSF TAPMTAAPPK DNADARNRLI DEDIKKENAQ RREERKREVR ANPVMLLGQA
ESGKSTLQKQ FQIYYAFKSL ERERPCWKPV VFFNIIKALR VIFNELEYRF SEYGNQSLEA
PLAVQNQLSE LRTKLLPLIS LEDSLASQLN GGVTIGSGGQ TGAFVRSGWQ TLVGGTSESD
VQVAEAVART VEVSTLTAKT LASSLSDIQT LWRHPTVKLL FQDRKVRLEE SAPFFLDEID
RISEPDYVPT TDDILNVRLQ TLGIMEHSFP VTMGGLSYNW KLYDVGGAYL EEDSKVNRIE
DSLQLFSAIC SSKLLKDADL VLLLNKADLL KKKLAAGILI RQFITSYGDR ANNFEAASNY
FKSHFQQVHR KKDPWKRSLW LHYTTMLDVK ATQKIISNVG EAIIRKHIAE IGLT
//
