ID K5X011_AGABU Unreviewed; 598 AA.
AC K5X011;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Pseudouridine synthase I TruA alpha/beta domain-containing protein {ECO:0000259|Pfam:PF01416};
GN ORFNames=AGABI1DRAFT_108952 {ECO:0000313|EMBL:EKM76207.1};
OS Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC
OS 10392) (White button mushroom).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Agaricus.
OX NCBI_TaxID=597362 {ECO:0000313|EMBL:EKM76207.1, ECO:0000313|Proteomes:UP000008493};
RN [1] {ECO:0000313|Proteomes:UP000008493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB137-S8 / ATCC MYA-4627 / FGSC 10392
RC {ECO:0000313|Proteomes:UP000008493};
RX PubMed=23045686; DOI=10.1073/pnas.1206847109;
RA Morin E., Kohler A., Baker A.R., Foulongne-Oriol M., Lombard V., Nagy L.G.,
RA Ohm R.A., Patyshakuliyeva A., Brun A., Aerts A.L., Bailey A.M.,
RA Billette C., Coutinho P.M., Deakin G., Doddapaneni H., Floudas D.,
RA Grimwood J., Hilden K., Kuees U., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lucas S.M., Murat C., Riley R.W., Salamov A.A., Schmutz J., Subramanian V.,
RA Woesten H.A.B., Xu J., Eastwood D.C., Foster G.D., Sonnenberg A.S.,
RA Cullen D., de Vries R.P., Lundell T., Hibbett D.S., Henrissat B.,
RA Burton K.S., Kerrigan R.W., Challen M.P., Grigoriev I.V., Martin F.;
RT "Genome sequence of the button mushroom Agaricus bisporus reveals
RT mechanisms governing adaptation to a humic-rich ecological niche.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:17501-17506(2012).
CC -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC {ECO:0000256|ARBA:ARBA00009375}.
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DR EMBL; JH971404; EKM76207.1; -; Genomic_DNA.
DR RefSeq; XP_007333164.1; XM_007333102.1.
DR AlphaFoldDB; K5X011; -.
DR STRING; 597362.K5X011; -.
DR GeneID; 18822663; -.
DR KEGG; abp:AGABI1DRAFT108952; -.
DR eggNOG; KOG2554; Eukaryota.
DR HOGENOM; CLU_014673_2_2_1; -.
DR InParanoid; K5X011; -.
DR OMA; SCRERRY; -.
DR OrthoDB; 167554at2759; -.
DR Proteomes; UP000008493; Unassembled WGS sequence.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR HAMAP; MF_00171; TruA; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR001406; PsdUridine_synth_TruA.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11142:SF5; TRNA PSEUDOURIDINE(38_39) SYNTHASE; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000008493};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 283..412
FT /note="Pseudouridine synthase I TruA alpha/beta"
FT /evidence="ECO:0000259|Pfam:PF01416"
FT REGION 35..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 67244 MW; 2753C98B80E463F7 CRC64;
MTTNQRSADY SAWSREQLIE RLIALEGPKL VKESRPSVSP ASVIPVPPRK HNENQNTIPP
PTNIIRPPSK EFNFSNHPKR KIALKFCYSG WEYGGLAYQT GPTQLPTVEA VLFEAFAKAR
LIDRDGGMEG CGWEKCGRTD KGVSAAGQVI SLWLRSAVGS VEEEQGKGKG TEIGLVNPVE
EGSTNQHQDS GVPGLSEEDF GTLDLSELGS PIAATTILQD SSSKSRHELD YVGILNRLLP
PTIRILAWAP VAENFSARFS CKYRHYKYFF SSHLLDISAM REAATHLIGE HDFRNLCKVD
AQKQITMFRR NILRADIEPV VDPSGNNDEA MFVFNLVGSA FLYHQVRHIM AILFLVGTGL
EEPSLVTKLM NAFDGAENRD LAICETRLEV LDRKPEYQMA DALPLMLWDC AYAEEDVKWR
TGTLEPSAQD HNHDTDEHSR RCGLGTESNL YLQLHSIWNR SRIYNVLDGH FLRAAEAHHR
PPTSPLPLIT GTSLNDPSSL NYPLGGGTYK RVQKYVPVLT RNRLDTVEMI NERWRNGKGS
RKAEKRTFVF KTRISAVNRF EHFWRNDGRN KALKIHHALP HPPTLESEAK ETIANLEA
//
