ID K5X900_AGABU Unreviewed; 517 AA.
AC K5X900;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=GTP cyclohydrolase II domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AGABI1DRAFT_74801 {ECO:0000313|EMBL:EKM79678.1};
OS Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC
OS 10392) (White button mushroom).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Agaricus.
OX NCBI_TaxID=597362 {ECO:0000313|EMBL:EKM79678.1, ECO:0000313|Proteomes:UP000008493};
RN [1] {ECO:0000313|Proteomes:UP000008493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB137-S8 / ATCC MYA-4627 / FGSC 10392
RC {ECO:0000313|Proteomes:UP000008493};
RX PubMed=23045686; DOI=10.1073/pnas.1206847109;
RA Morin E., Kohler A., Baker A.R., Foulongne-Oriol M., Lombard V., Nagy L.G.,
RA Ohm R.A., Patyshakuliyeva A., Brun A., Aerts A.L., Bailey A.M.,
RA Billette C., Coutinho P.M., Deakin G., Doddapaneni H., Floudas D.,
RA Grimwood J., Hilden K., Kuees U., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lucas S.M., Murat C., Riley R.W., Salamov A.A., Schmutz J., Subramanian V.,
RA Woesten H.A.B., Xu J., Eastwood D.C., Foster G.D., Sonnenberg A.S.,
RA Cullen D., de Vries R.P., Lundell T., Hibbett D.S., Henrissat B.,
RA Burton K.S., Kerrigan R.W., Challen M.P., Grigoriev I.V., Martin F.;
RT "Genome sequence of the button mushroom Agaricus bisporus reveals
RT mechanisms governing adaptation to a humic-rich ecological niche.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:17501-17506(2012).
CC -!- SIMILARITY: Belongs to the GTP cyclohydrolase II family.
CC {ECO:0000256|ARBA:ARBA00008131}.
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DR EMBL; JH971390; EKM79678.1; -; Genomic_DNA.
DR RefSeq; XP_007329823.1; XM_007329761.1.
DR AlphaFoldDB; K5X900; -.
DR STRING; 597362.K5X900; -.
DR GeneID; 18831220; -.
DR KEGG; abp:AGABI1DRAFT74801; -.
DR eggNOG; KOG1284; Eukaryota.
DR HOGENOM; CLU_029639_2_0_1; -.
DR InParanoid; K5X900; -.
DR OMA; FQQLMPD; -.
DR OrthoDB; 46806at2759; -.
DR Proteomes; UP000008493; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:InterPro.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:InterPro.
DR CDD; cd00641; GTP_cyclohydro2; 1.
DR Gene3D; 3.40.50.10990; GTP cyclohydrolase II; 1.
DR InterPro; IPR022163; GTP_CH_N.
DR InterPro; IPR032677; GTP_cyclohydro_II.
DR InterPro; IPR000926; RibA.
DR InterPro; IPR036144; RibA-like_sf.
DR PANTHER; PTHR47259; -; 1.
DR PANTHER; PTHR47259:SF2; URACIL-REGULATED PROTEIN 1; 1.
DR Pfam; PF12471; GTP_CH_N; 1.
DR Pfam; PF00925; GTP_cyclohydro2; 1.
DR SUPFAM; SSF142695; RibA-like; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008493}.
FT DOMAIN 89..295
FT /note="GTP cyclohydrolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12471"
FT DOMAIN 334..468
FT /note="GTP cyclohydrolase II"
FT /evidence="ECO:0000259|Pfam:PF00925"
FT REGION 30..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 57296 MW; AD9014F159FEEA48 CRC64;
MSSTDAVLTQ ILAQLEAMQL NQQAMQAKID ALGNRSTSPP LEPVKDKDKE PLSPISSVPP
PILGGPSASP PRKGAFTDKE REKLLYPGRV NLSTYPDQHG IKPHPLRWGA SDPHERGPII
CSRLPSSIKR RNGLGAHSGS YSIYRSLSIA MGSLSPTHKP DYTMTEPPVD FPGQPSWFDP
KKIVSFDPWG HLVQIVFKDE MESGLDIRPS IAVTKAHLKM SELDEAARKG TLVVDGNVVM
KSRPLMNEDG SVSSEDNGVE VFVSKAAVEP VWYLPGVAER FEISESLLRR ALFEETGGMY
PELITRPDIK VFLPPIGNLT VYIFGNPAYL SDESKELTLR VHDECNGSDV FGSDICTCKP
YLVYAIEECI RGAQKGGIGV VVYFRKEGRA LGEVTKYLVY NLRKRGGDSA DKYFKSTEMI
AGVKDMRFQA LMPDVLHWLG IRKIDKMVSM SDMKYDAIVK SGIPILKRYD LPDHLIPPDS
RVEIDAKIAA GYFSSAKKIT EADLFKTVGR AWEETEH
//