ID K5XLB7_AGABU Unreviewed; 1132 AA.
AC K5XLB7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=DUF726-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AGABI1DRAFT_117749 {ECO:0000313|EMBL:EKM84363.1};
OS Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC
OS 10392) (White button mushroom).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Agaricus.
OX NCBI_TaxID=597362 {ECO:0000313|EMBL:EKM84363.1, ECO:0000313|Proteomes:UP000008493};
RN [1] {ECO:0000313|Proteomes:UP000008493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB137-S8 / ATCC MYA-4627 / FGSC 10392
RC {ECO:0000313|Proteomes:UP000008493};
RX PubMed=23045686; DOI=10.1073/pnas.1206847109;
RA Morin E., Kohler A., Baker A.R., Foulongne-Oriol M., Lombard V., Nagy L.G.,
RA Ohm R.A., Patyshakuliyeva A., Brun A., Aerts A.L., Bailey A.M.,
RA Billette C., Coutinho P.M., Deakin G., Doddapaneni H., Floudas D.,
RA Grimwood J., Hilden K., Kuees U., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lucas S.M., Murat C., Riley R.W., Salamov A.A., Schmutz J., Subramanian V.,
RA Woesten H.A.B., Xu J., Eastwood D.C., Foster G.D., Sonnenberg A.S.,
RA Cullen D., de Vries R.P., Lundell T., Hibbett D.S., Henrissat B.,
RA Burton K.S., Kerrigan R.W., Challen M.P., Grigoriev I.V., Martin F.;
RT "Genome sequence of the button mushroom Agaricus bisporus reveals
RT mechanisms governing adaptation to a humic-rich ecological niche.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:17501-17506(2012).
CC -!- SIMILARITY: Belongs to the TMCO4 family.
CC {ECO:0000256|ARBA:ARBA00009824}.
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DR EMBL; JH971385; EKM84363.1; -; Genomic_DNA.
DR RefSeq; XP_007325965.1; XM_007325903.1.
DR AlphaFoldDB; K5XLB7; -.
DR STRING; 597362.K5XLB7; -.
DR GeneID; 18825367; -.
DR KEGG; abp:AGABI1DRAFT117749; -.
DR eggNOG; KOG2385; Eukaryota.
DR HOGENOM; CLU_001695_0_1_1; -.
DR InParanoid; K5XLB7; -.
DR OMA; AIQNMEL; -.
DR OrthoDB; 8526at2759; -.
DR Proteomes; UP000008493; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007941; DUF726.
DR PANTHER; PTHR17920:SF24; LIPASE MIL1-RELATED; 1.
DR PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR Pfam; PF05277; DUF726; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008493};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 404..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..912
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1132 AA; 121209 MW; A41D8041F813836F CRC64;
MPVTSAAATP PDIFDDDDDG WQEMPVVRQD YLATDLDEED RKKYHYRAPS TDTKAAGSSN
ATGNLIDFDD SGYEWRSKAE MNEAEYTRLR MKEDEESDEV ALRTKYLFDE DAAMTPLSQM
QATKKLLTES QRIAYVGLCA LTAREMTQAL RLFKRKELKG AVANMELWVL KIMGRLYYHM
ELETPEQKMI ENLAEHGVQA MDLVPSLMTT HTVANPEYDP VEARKRNEES AANEPDNPDL
DDADDISIQT LVDQAPSSKP ASPLQSTTIS VPSTPSSQTS FTATNTASNP TKTTARVLGE
TTTHMAGVTT SLSSTDKNVT LDIRWTVLCD LFLILIADSV YDARSRVLLE SIAQKLGLGW
LDVVRFESRV TEALEIQEDI ENLEQREIMD GVQKSGRRRR YMMLGLATLG GGLVLGLSAG
LLAPVIGVGL AGAFSAIGIT GTGVFLGGTA GAAAITTGGV LTGSAIAGRG MARRTRHVRT
FDILPLHNNK RVNCILTVPG FMTSVNDDVR LPFSVLEPIV GDVFSVLWEP DMIRETGSAL
QIMTAEVLSQ VGMTILGATA MTALMSALQW PIILTKLGYL IDNPWNNALD RAKAAGLVLA
DVLQQRHLGV RPITLIGFSL GARVIFYALL ELSRQKAYGI VQDVFLLGAT LTASQSTWCQ
TRAVVSGRYV NAFAKNDWVL NYLFRATSGG IGTVAGLRPV LHVPGLENVD VTDKISGHMS
YRTFMPLILD QLGFPVSAHY FDEPAEDIIM TPEVDKHEET GWFKRKKQAN HMDACPPPTA
SSDTKQNGTA AVATSTAVAG AAAGAIASST SLSGDDDSDL PPRMPSSTHL PHTSSDIALG
GSTTPSASAR TSISETETST PSEDPIAHIP KHAGFDLEAM KKIVGDANHN PSELQVPSQN
VHVGNSSRVS LSPLPPTPKP LPKGFTAETE EYRKESGFVP MSPSELLEQE KENANAGLAK
SFAESVSLKG ETSSSGFTAS PELNADASSP TLTFGSTYDA PAWASSSTNV TPMAVRPERQ
DSYGFGHNGF KSTYTSPSTS SSTMQNPFAV SSNNNNALSM NDFGYGGGGF GGNNSFGGMG
MDSGLSFGAA DGTIVSGGAA YGGSLDSWNV PGDYGKKQSS STSSGFGSNP WS
//
