ID K5XMF0_AGABU Unreviewed; 759 AA.
AC K5XMF0;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=PABS domain-containing protein {ECO:0000259|PROSITE:PS51006};
GN ORFNames=AGABI1DRAFT_64147 {ECO:0000313|EMBL:EKM75755.1};
OS Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 / FGSC
OS 10392) (White button mushroom).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Agaricaceae; Agaricus.
OX NCBI_TaxID=597362 {ECO:0000313|EMBL:EKM75755.1, ECO:0000313|Proteomes:UP000008493};
RN [1] {ECO:0000313|Proteomes:UP000008493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB137-S8 / ATCC MYA-4627 / FGSC 10392
RC {ECO:0000313|Proteomes:UP000008493};
RX PubMed=23045686; DOI=10.1073/pnas.1206847109;
RA Morin E., Kohler A., Baker A.R., Foulongne-Oriol M., Lombard V., Nagy L.G.,
RA Ohm R.A., Patyshakuliyeva A., Brun A., Aerts A.L., Bailey A.M.,
RA Billette C., Coutinho P.M., Deakin G., Doddapaneni H., Floudas D.,
RA Grimwood J., Hilden K., Kuees U., LaButti K.M., Lapidus A., Lindquist E.A.,
RA Lucas S.M., Murat C., Riley R.W., Salamov A.A., Schmutz J., Subramanian V.,
RA Woesten H.A.B., Xu J., Eastwood D.C., Foster G.D., Sonnenberg A.S.,
RA Cullen D., de Vries R.P., Lundell T., Hibbett D.S., Henrissat B.,
RA Burton K.S., Kerrigan R.W., Challen M.P., Grigoriev I.V., Martin F.;
RT "Genome sequence of the button mushroom Agaricus bisporus reveals
RT mechanisms governing adaptation to a humic-rich ecological niche.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:17501-17506(2012).
CC -!- SIMILARITY: Belongs to the spermidine/spermine synthase family.
CC {ECO:0000256|ARBA:ARBA00007867, ECO:0000256|RuleBase:RU003836}.
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DR EMBL; JH971409; EKM75755.1; -; Genomic_DNA.
DR RefSeq; XP_007333601.1; XM_007333539.1.
DR AlphaFoldDB; K5XMF0; -.
DR SMR; K5XMF0; -.
DR STRING; 597362.K5XMF0; -.
DR GeneID; 18830481; -.
DR KEGG; abp:AGABI1DRAFT64147; -.
DR eggNOG; KOG0172; Eukaryota.
DR eggNOG; KOG1562; Eukaryota.
DR HOGENOM; CLU_016207_2_0_1; -.
DR InParanoid; K5XMF0; -.
DR OMA; PCAEYVV; -.
DR OrthoDB; 2184985at2759; -.
DR Proteomes; UP000008493; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006596; P:polyamine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.1870.10; Domain 3, Saccharopine reductase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.30.140.10; Spermidine synthase, tetramerisation domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR HAMAP; MF_00198; Spermidine_synth; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR030374; PABS.
DR InterPro; IPR030373; PABS_CS.
DR InterPro; IPR032095; Sacchrp_dh-like_C.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR001045; Spermi_synthase.
DR InterPro; IPR035246; Spermidine_synt_N.
DR InterPro; IPR037163; Spermidine_synt_N_sf.
DR NCBIfam; TIGR00417; speE; 1.
DR PANTHER; PTHR11133:SF25; ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11133; SACCHAROPINE DEHYDROGENASE; 1.
DR Pfam; PF16653; Sacchrp_dh_C; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR Pfam; PF17284; Spermine_synt_N; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS01330; PABS_1; 1.
DR PROSITE; PS51006; PABS_2; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW Lysine biosynthesis {ECO:0000256|ARBA:ARBA00023154};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Polyamine biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00354};
KW Reference proteome {ECO:0000313|Proteomes:UP000008493};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU00354}.
FT DOMAIN 11..246
FT /note="PABS"
FT /evidence="ECO:0000259|PROSITE:PS51006"
FT ACT_SITE 166
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00354"
SQ SEQUENCE 759 AA; 83634 MW; 591AC5F55BACAD7D CRC64;
MAPLSHPSIV DGWFREISSQ WPGQAMTLKV NKILHVEKSL YQDVLVFESE TFGNVLVLDG
VIQCTERDEF SYQEMIAHLP LASHPNPKKV LVVGGGDGGV VREVLKHDTV EQVVLCDIDE
AVIRVSKQYL PHMSGLLADP RVTVHIGDGF KFLSNNQNTY DVIITDSSDP VGPAESLFQK
PYFELLHNAL TPGGHISTQG ECQWIQLSLI QDLKRVTTEI FQTTEYAYTT IPTYPSGQIG
FMVCAKAPGR DLRTPVREVK NTKYYNKDIH RTAFVLPEFT RSVLEEGKDI RPKFGRAAKA
VEAEAAGRKR KRVLLLGSGF VARPCAEYVV RNPENELTIA CRTLSSAKAL AESLLATTAI
SLDVNSTDAL EKAIAEHDLV ISLIPYTYHA AVIRAAIKSK THVVTTSYVN PLMRELDAEA
KAAGIVVFNE IGLDPGIDHL YAVKTINEVH AKGGKIKQFL SFCGGLPAPE CADNPLGYKF
SWSSRGVLLA LLNTASYISN SQAITVTGAE LMGHAKPYYI SPAFAFVGYP NRDSTPFREW
YHIPEAETVL RGTLRYQGFP EFIGTLVKLG WLDQTEKEWL KEGITWKQIT KNLVGATAQD
DLTEAAIVDR INTKVQFSSA SEAERIVSGL RWIGTLSDEP AQIRAGNLLD TLCARLEGLM
KYEVGERDLV MLQHKFVVEW ADGTTQILTS TLEAYGSTVP GGYSAMALTV GVPCGITVQL
VLDGVLKEPG VHAPYDYEVC EKIRKVLEIE GLGMVEKVM
//
