ID K6A2X1_9BACT Unreviewed; 1075 AA.
AC K6A2X1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=HMPREF1077_01933 {ECO:0000313|EMBL:EKN10023.1};
OS Parabacteroides johnsonii CL02T12C29.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC Parabacteroides.
OX NCBI_TaxID=999419 {ECO:0000313|EMBL:EKN10023.1, ECO:0000313|Proteomes:UP000001218};
RN [1] {ECO:0000313|EMBL:EKN10023.1, ECO:0000313|Proteomes:UP000001218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL02T12C29 {ECO:0000313|EMBL:EKN10023.1,
RC ECO:0000313|Proteomes:UP000001218};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Zitomersky N.L., Coyne M.J.,
RA Comstock L.E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Chapman S.B.,
RA Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M., Heiman D.,
RA Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Parabacteroides johnsonii CL02T12C29.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKN10023.1}.
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DR EMBL; AGZP01000017; EKN10023.1; -; Genomic_DNA.
DR RefSeq; WP_008156538.1; NZ_JH976466.1.
DR AlphaFoldDB; K6A2X1; -.
DR PATRIC; fig|999419.3.peg.1981; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_010638_0_0_10; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000001218; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.3170.10; Recbcd, chain B, domain 2; 1.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000001218}.
FT DOMAIN 1..462
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 485..744
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 7..14
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1075 AA; 122347 MW; 93A565327CC19459 CRC64;
MLTVYRASAG AGKTHKLTGE YLTLLFTGPG AFRRILAVTF TNKATDEMKT RIVDELYNLA
SGRKSDYVEL LTSTYSLTED QMRKQAAKIL IDILHDYSAF NISTIDRFFQ QTMRAFTREI
GLQGGYGIEM DQELVLTTAI DNLLSDLEKP ESKDLLGWLL RFAEDKIENG GEWNLRKDIM
ALSREVFKES YKAFSEAVGR DIEDKKALDD YKNELYGIIR SVESAAKELG ERGLAILNKY
GLKVTDFKGG SRSPLTLLDR LVQGEMKEPS ATFIGLADNL DGCFTKTVSL GTRQIIGCAF
EDGLNDCIKG IISLFNNLTA YNTAREIVRY YYTLGILTDV SRQIAAYREE KNVMLIADTT
ELLNKVIGGS DAPFIYEKTG THVDHYMIDE FQDTSGMQWN NFRPLIEESL AHSRDNLIVG
DVKQSIYRFR NSDWKLLDEQ VQADFSPEVV HEETLKDNWR SCRNIVEFNN ALFTTLPGVL
QTVYNEALSV SSLSEEQRAA FFTKIMSAYD KSFQQVPPPF MQKDGHVRIE FLSGDDEKDW
KEEALGRLPG VLEKLQDNGY VLKDIAILVR TNQEGAQVAD TLLAYKEEHP SDRYNYDIIS
DEALFVSGST AVRFMVSLLR YLKNPEDRTN GQIALYSYQV LKGIFGVEAP AFPPEVISVL
QILSRQSLYE ITEGLFRLFA DDFPENEQVF VQAFLDMVSE YTQKESADLN RFLKWWDETG
CRKTIATPDG QNAIRILTVH KSKGLGFKVV IIPFGDWEID HKPTKPVILW CHPEEKPFDR
LHLVPVRYGQ SLGKTIFAGD YFKERLHAFI DNLNTLYVAF TRSKEELIVF SPRPKKMKEE
TGEVEKISTL TDALWAGLRT DMPDTRGGEK LISLPAAFDT GTGVFELGDW WHPVAKEDNG
DIQEIGMARL SSISPDDRLQ LRLHGKGYFF DNARRKHGAL MHEVLSRIRT RKDIPQSVER
YRQEGVIDRE EAASLVARLE ELLSLPEAAS WYDGTARVLN EVDILFGKGL SKRPDRVMIT
GNSVIVIDYK FGEHTDQRYH SQVRNYLKLI RQMGYGEVEG FLWYVELNKI EAVKG
//
