ID K6T2T7_9CLOT Unreviewed; 959 AA.
AC K6T2T7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein {ECO:0000313|EMBL:EKQ53618.1};
GN ORFNames=A370_03663 {ECO:0000313|EMBL:EKQ53618.1};
OS Clostridium sp. Maddingley MBC34-26.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1196322 {ECO:0000313|EMBL:EKQ53618.1, ECO:0000313|Proteomes:UP000001325};
RN [1] {ECO:0000313|EMBL:EKQ53618.1, ECO:0000313|Proteomes:UP000001325}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Maddingley MBC34-26 {ECO:0000313|Proteomes:UP000001325};
RX PubMed=23405323;
RA Rosewarne C.P., Greenfield P., Li D., Tran-Dinh N., Bradbury M.I.,
RA Midgley D.J., Hendry P.;
RT "Draft Genome Sequence of Clostridium sp. Maddingley, Isolated from Coal-
RT Seam Gas Formation Water.";
RL Genome Announc. 1:E00081-12(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKQ53618.1}.
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DR EMBL; ALXI01000112; EKQ53618.1; -; Genomic_DNA.
DR AlphaFoldDB; K6T2T7; -.
DR STRING; 1196322.A370_03663; -.
DR PATRIC; fig|1196322.3.peg.3577; -.
DR eggNOG; COG5001; Bacteria.
DR Proteomes; UP000001325; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00130; PAS; 1.
DR CDD; cd12914; PDC1_DGC_like; 1.
DR CDD; cd12912; PDC2_MCP_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR029151; Sensor-like_sf.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF08447; PAS_3; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF103190; Sensory domain-like; 2.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001325};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 316..368
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 401..472
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 475..527
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 559..692
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 701..954
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT COILED 360..394
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 959 AA; 108921 MW; 2448DD448C6CF2F1 CRC64;
MHIKKKLPIT MIILISIPLL ILSYAIYNYT YMSVTNDSEN HIKQVTSIEG NALSTFVNYQ
IKEVELSARI ESVVELLKEA KQSEDLKQLI YKTEALNVDK LLTLRVKELN DVQHSFVCDL
KGNIIADSNS TGLMLNITDR EYFQQAINGE IAISDEIKSK ISNEDIIVVA SPVIDEQGNV
IGLYCNAIQI SAFNKYIENI TIGNTGYAYL VDDDGIMIAH PQKDKLGKPV ENSVLTKVVD
EKSYLNQTDT GFDTYVYNGT KKYFGYTVIP KINWILAVTQ NVDEVNAPAR LELYFIMGIT
LIMLVITSII SLLFSKSITN PISGLIAIMN KAENGDLSVS CDYDSNNELG KLSNNFNSMI
KKLSGSYEEL SAVYEELSAT EEELRCQYEE LVENEKALAI SEDRFKQALD GINDVIWEWD
IKANTFFASD KWEELTGYSN KNIDIKNFLK IILPNEELER IVKNYKTLTM SAEYFREEFE
ITTKSGDKKW ILNRARITMD SEGNPIKITG TISDITSIRQ ANDKIMELAY CDSLTGIPNR
TTLMSKLDEV INECVENNKL GAALFIDLDD FKRINDSLGH DIGDKLLKRI CTKAKSILNQ
NEILYRFGGD EFLILMCNVK AREQVINLSN KLLNIFKNYF IIDNKQVYIT CSIGICIFPT
DGKDKNSILK NADTAMYKAK EKGKNTFEFY NEEMSKKILK DMIIEKALRN GIENNYFYLQ
YQPQVNIEGK IIGVESLVRL KNEELGFVSP GEFIPIAEKT GLIITIGDWI METAIIKKLE
WLNNGYGDIR VSINVSSLQI HRPDFVEKVK KLVEKYKINP NFIELEITES VLMEQLDKNV
VILQELRDIG IRIALDDFGT GYSSLNYLRT IPLNTLKIDK SFIDDICIND KQGAIVDSII
EMAHKLGMEV VAEGIETIDQ LKVMKEKNCD IIQGYVYSRP LLSTDLENLL KKGFDNLIK
//
