ID K6TRE5_9CLOT Unreviewed; 926 AA.
AC K6TRE5;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Site-specific recombinase XerD {ECO:0000313|EMBL:EKQ54820.1};
GN ORFNames=A370_02973 {ECO:0000313|EMBL:EKQ54820.1};
OS Clostridium sp. Maddingley MBC34-26.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1196322 {ECO:0000313|EMBL:EKQ54820.1, ECO:0000313|Proteomes:UP000001325};
RN [1] {ECO:0000313|EMBL:EKQ54820.1, ECO:0000313|Proteomes:UP000001325}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Maddingley MBC34-26 {ECO:0000313|Proteomes:UP000001325};
RX PubMed=23405323;
RA Rosewarne C.P., Greenfield P., Li D., Tran-Dinh N., Bradbury M.I.,
RA Midgley D.J., Hendry P.;
RT "Draft Genome Sequence of Clostridium sp. Maddingley, Isolated from Coal-
RT Seam Gas Formation Water.";
RL Genome Announc. 1:E00081-12(2013).
CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC the cutting and rejoining of the recombining DNA molecules.
CC {ECO:0000256|ARBA:ARBA00003283}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC {ECO:0000256|ARBA:ARBA00008857}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKQ54820.1}.
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DR EMBL; ALXI01000097; EKQ54820.1; -; Genomic_DNA.
DR AlphaFoldDB; K6TRE5; -.
DR STRING; 1196322.A370_02973; -.
DR PATRIC; fig|1196322.3.peg.2887; -.
DR eggNOG; COG0582; Bacteria.
DR eggNOG; COG1961; Bacteria.
DR Proteomes; UP000001325; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR CDD; cd01189; INT_ICEBs1_C_like; 1.
DR CDD; cd00338; Ser_Recombinase; 1.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR Gene3D; 3.40.50.1390; Resolvase, N-terminal catalytic domain; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR038109; DNA_bind_recomb_sf.
DR InterPro; IPR011109; DNA_bind_recombinase_dom.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR InterPro; IPR006119; Resolv_N.
DR InterPro; IPR036162; Resolvase-like_N_sf.
DR InterPro; IPR025827; Zn_ribbon_recom_dom.
DR PANTHER; PTHR30461; DNA-INVERTASE FROM LAMBDOID PROPHAGE; 1.
DR PANTHER; PTHR30461:SF2; RESOLVASE HOMOLOG YNEB; 1.
DR Pfam; PF14659; Phage_int_SAM_3; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR Pfam; PF07508; Recombinase; 1.
DR Pfam; PF00239; Resolvase; 1.
DR Pfam; PF13408; Zn_ribbon_recom; 1.
DR SMART; SM00857; Resolvase; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF53041; Resolvase-like; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51737; RECOMBINASE_DNA_BIND; 1.
DR PROSITE; PS51736; RECOMBINASES_3; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01248}; Reference proteome {ECO:0000313|Proteomes:UP000001325}.
FT DOMAIN 26..174
FT /note="Resolvase/invertase-type recombinase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51736"
FT DOMAIN 184..309
FT /note="Recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51737"
FT DOMAIN 602..685
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 713..913
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
FT COILED 410..472
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 926 AA; 107167 MW; C3CA5D41C549E3CF CRC64;
MADVQVIKAS TSRVNRKNAK VIERLRVAAY CRVSTDSEEQ LSSYNSQVEH YRNMVENKPD
WALVDIYADE AISGTQTDKR LDFQRMINDA VDGKIDLIIT KSISRFARNT LDTLKYVRLL
KEHNVAILFE KENINTLTMN GEMLLVILSS LAQQESESIS ANVKMGLKMK MKRGEMVGFN
GCLGYDYDPI NKVITINEEE AKTVRYIFQR YVEGAGCFVI AKELTKLKYK TKKGNTNWND
GSVRGIIKNE KYKGDLLLGK TFTVDPISHR RLDNMGEEEK YYINSHHEPI ISEEMFNEAQ
KILNKRNSGS NNMGRKEKYS RQFAFSSKIE CGFCGGTATR RRWHSNTSHE KTIWHCVVST
KKGKKYCPDS KGIDEKIIEN AFLEAFNMFC LQNKEIVEEF METVENTINA TNSIKELKKL
QREVSAIENK IRKLVDMRID EMIDKDTYEL KYTELSTELE KLKTQRDEAE LVNEDNIDVK
KRIESFRKVF DSNKPIKEFD RVVFESAVNK IILGGTDEEG NKDPYMLTFI FNSGMSHSLK
GEGSVRKKGN KWYYSFEVGK ENGKRKKIER AGGSTKKEAL ESLRKAIIEF ENAGSYIDES
NISVSDYFDY WFKEYVLLNC KPNTQVSYKQ LIQNHIKPQI GIYHLKKITP AKLQELINTK
YRNGFSKNYL SNLYGVLSGA FKNAVYPYQL IKENPMTFVK MPKYNQKLIN NLEDLKIITL
EQYNTILKRF PYGSNMHIPL QIGFHTGMRA AEVMSLTWDC IDLNAHTIKV EKILYRNEFK
QWVFGTPKTQ SSYRTIKIGG TLISLLKRFH TDQKANKLRY GEYYIKNDYD FVCLKENGEL
LTTDSIKYLS RIVNYELNIP FKFHSLRHTH ATMLLEAGAN IKDIQERLGH SKSSITMDVY
SHVTKKMSND SVNIFENMLK INLPTT
//
