ID   K6TWI1_9CLOT            Unreviewed;       989 AA.
AC   K6TWI1;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Diguanylate cyclase (GGDEF) domain-containing protein {ECO:0000313|EMBL:EKQ51342.1};
GN   ORFNames=A370_04953 {ECO:0000313|EMBL:EKQ51342.1};
OS   Clostridium sp. Maddingley MBC34-26.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1196322 {ECO:0000313|EMBL:EKQ51342.1, ECO:0000313|Proteomes:UP000001325};
RN   [1] {ECO:0000313|EMBL:EKQ51342.1, ECO:0000313|Proteomes:UP000001325}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Maddingley MBC34-26 {ECO:0000313|Proteomes:UP000001325};
RX   PubMed=23405323;
RA   Rosewarne C.P., Greenfield P., Li D., Tran-Dinh N., Bradbury M.I.,
RA   Midgley D.J., Hendry P.;
RT   "Draft Genome Sequence of Clostridium sp. Maddingley, Isolated from Coal-
RT   Seam Gas Formation Water.";
RL   Genome Announc. 1:E00081-12(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKQ51342.1}.
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DR   EMBL; ALXI01000161; EKQ51342.1; -; Genomic_DNA.
DR   AlphaFoldDB; K6TWI1; -.
DR   STRING; 1196322.A370_04953; -.
DR   PATRIC; fig|1196322.3.peg.4817; -.
DR   eggNOG; COG5001; Bacteria.
DR   Proteomes; UP000001325; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd18773; PDC1_HK_sensor; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF78; CYCLIC DI-GMP PHOSPHODIESTERASE PDEI-RELATED; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001325};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        14..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        374..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          589..724
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          733..980
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   989 AA;  114046 MW;  8CAE9CFC243632CA CRC64;
     MSFIKNRNSI IKKLLIPMII IMIVQVFLYL SAISFSGIIE ILRDNSFNIL NQKIESRKNY
     LQNEMLQHWS NVGESESVIN KAILSKLENR GLTVKDLKNN PKLSTELLND ISSDIIFMLR
     KNYVTGAFII LDNDSEEKTG LYFRDLDPNS NPNDNSDLLM ERGPASIAQK LGIPLDTWWN
     NKFIFNPNNE VLASPNEFFT KPLDAAKGNK DLSYKDLGYW SKPFSLSEKD IKVITYSVPL
     IDNNNQPYGV MGIALSLKYL NTLLNYEEID PNGNGVYLLG ANSNNDLNFE KMMSTGPMVN
     KILGEEQDIR LNNKEVYNSI YEIKEPESNK IAYACTKYLN LYNSNTPFEN EKWALIGIVE
     KDNLLYYSTR FKNLLIVSLI ISSVIGIMLV IITGGRITRP IRNLAKDVRT SNPREPLELR
     KINISEIDEL SSAIMALSTN VADSASKLSQ IIKLFNMPIG AFEYKKGEST VLCTETFLEV
     VGIEEPNKFD KYIDIKSFEK IIDGITMNKE LRVDDTYWIE GKNGKPKWIK LKMLQEDSRT
     FGVISDVSQE ILEKQKIEYE RDYDILTNIL NRRAFYNNVK EKIKNDDLKI GAFIMWDLDN
     LKYVNDTYGH DYGDEYIRKA SNQLKKFEEY GGIIGRRSGD EFYTFLYGYE NKKEIRRIIK
     EVHKNIENSI LKLPNNREIK IRISTGIAWY PDDATTFEEL AKYSDFAMYK IKRTVKGNIS
     EFNKDEYSED SFLLSSQEDL NKLLDEELIE YAFQPIIDAR NGSIFAYEAL MRSQLESLRS
     PLHIIKLATA DFRLYEIERI TFFKALEGFL KNIEKFKEAK LFINSIPNQA LSNEDCEKFE
     QLYGEHLDRL VIELLENERS NGEFITKKRK SIEKWNAKLA IDDFGSGYNN EAVLLAITPD
     FVKIDMGIVR GIDKDINRQI ISKNLISYAK QRGIKVVAEG VETSEELEKL IELGVDYLQG
     YHFSKPEFIP PEISDDLINE ILKINEKFN
//