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Database: UniProt
Entry: K6U324_9CLOT
LinkDB: K6U324_9CLOT
Original site: K6U324_9CLOT 
ID   K6U324_9CLOT            Unreviewed;       324 AA.
AC   K6U324;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=PTS system mannose-specific EIIAB component {ECO:0000256|ARBA:ARBA00021685};
DE            EC=2.7.1.191 {ECO:0000256|ARBA:ARBA00011929};
DE   AltName: Full=EIIAB-Man {ECO:0000256|ARBA:ARBA00032197};
DE   AltName: Full=EIII-Man {ECO:0000256|ARBA:ARBA00030229};
GN   ORFNames=A370_02702 {ECO:0000313|EMBL:EKQ55486.1};
OS   Clostridium sp. Maddingley MBC34-26.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1196322 {ECO:0000313|EMBL:EKQ55486.1, ECO:0000313|Proteomes:UP000001325};
RN   [1] {ECO:0000313|EMBL:EKQ55486.1, ECO:0000313|Proteomes:UP000001325}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Maddingley MBC34-26 {ECO:0000313|Proteomes:UP000001325};
RX   PubMed=23405323;
RA   Rosewarne C.P., Greenfield P., Li D., Tran-Dinh N., Bradbury M.I.,
RA   Midgley D.J., Hendry P.;
RT   "Draft Genome Sequence of Clostridium sp. Maddingley, Isolated from Coal-
RT   Seam Gas Formation Water.";
RL   Genome Announc. 1:E00081-12(2013).
CC   -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC       system (sugar PTS), a major carbohydrate active transport system,
CC       catalyzes the phosphorylation of incoming sugar substrates
CC       concomitantly with their translocation across the cell membrane. The
CC       enzyme II ManXYZ PTS system is involved in mannose transport.
CC       {ECO:0000256|ARBA:ARBA00023757}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-mannose(out) + N(pros)-phospho-L-histidyl-[protein] = D-
CC         mannose 6-phosphate(in) + L-histidyl-[protein]; Xref=Rhea:RHEA:49232,
CC         Rhea:RHEA-COMP:9745, Rhea:RHEA-COMP:9746, ChEBI:CHEBI:4208,
CC         ChEBI:CHEBI:29979, ChEBI:CHEBI:58735, ChEBI:CHEBI:64837;
CC         EC=2.7.1.191; Evidence={ECO:0000256|ARBA:ARBA00000514};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKQ55486.1}.
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DR   EMBL; ALXI01000094; EKQ55486.1; -; Genomic_DNA.
DR   AlphaFoldDB; K6U324; -.
DR   STRING; 1196322.A370_02702; -.
DR   PATRIC; fig|1196322.3.peg.2618; -.
DR   eggNOG; COG2893; Bacteria.
DR   eggNOG; COG3444; Bacteria.
DR   Proteomes; UP000001325; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00006; PTS_IIA_man; 1.
DR   CDD; cd00001; PTS_IIB_man; 1.
DR   Gene3D; 3.40.50.510; Phosphotransferase system, mannose-type IIA component; 1.
DR   Gene3D; 3.40.35.10; Phosphotransferase system, sorbose subfamily IIB component; 1.
DR   InterPro; IPR013789; PTS_EIIA_man.
DR   InterPro; IPR004701; PTS_EIIA_man-typ.
DR   InterPro; IPR036662; PTS_EIIA_man-typ_sf.
DR   InterPro; IPR033887; PTS_IIA_man.
DR   InterPro; IPR004720; PTS_IIB_sorbose-sp.
DR   InterPro; IPR036667; PTS_IIB_sorbose-sp_sf.
DR   NCBIfam; TIGR00824; EIIA-man; 1.
DR   PANTHER; PTHR33799:SF1; PHOSPHOTRANSFERASE ENZYME IIA COMPONENT YADI-RELATED; 1.
DR   PANTHER; PTHR33799; PTS PERMEASE-RELATED-RELATED; 1.
DR   Pfam; PF03610; EIIA-man; 1.
DR   Pfam; PF03830; PTSIIB_sorb; 1.
DR   SUPFAM; SSF52728; PTS IIb component; 1.
DR   SUPFAM; SSF53062; PTS system fructose IIA component-like; 1.
DR   PROSITE; PS51096; PTS_EIIA_TYPE_4; 1.
DR   PROSITE; PS51101; PTS_EIIB_TYPE_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001325};
KW   Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          1..126
FT                   /note="PTS EIIA type-4"
FT                   /evidence="ECO:0000259|PROSITE:PS51096"
FT   DOMAIN          154..320
FT                   /note="PTS EIIB type-4"
FT                   /evidence="ECO:0000259|PROSITE:PS51101"
SQ   SEQUENCE   324 AA;  35186 MW;  62DDBA712F492014 CRC64;
     MVGIILASHG EFATGIMQSG KMIFGEQENV KAVTLMPSEG PDDLRAKMKE AIASFDNQDE
     VLFLVDLWGG TPFNQANMLF EEHKDKWAIV AGLNLPMLIE AYGARLSMES AHEIATYILN
     AGKEGVKVKP EALEPATGKT SGAGAGQSNA GAPGSFEYVL ARIDSRLLHG QVATAWTKTV
     NPTRIIVVSD DVARDKLRKN LITQAAPPGV KAHVVPVDHM IKLAKDDKHF GGQRAMLLFE
     NPKDVLRAVE GGIPLKTINV GSMAHSLGKV QPSKVLAFNQ EDINIFNKLK QAGLTFDVRK
     VPNDSKANMD EILKKAQEEL KKLK
//
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