ID K6W5I3_9MICO Unreviewed; 575 AA.
AC K6W5I3;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=KILIM_005_00470 {ECO:0000313|EMBL:GAB94430.1};
OS Kineosphaera limosa NBRC 100340.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermatophilaceae;
OC Kineosphaera.
OX NCBI_TaxID=1184609 {ECO:0000313|EMBL:GAB94430.1, ECO:0000313|Proteomes:UP000008366};
RN [1] {ECO:0000313|EMBL:GAB94430.1, ECO:0000313|Proteomes:UP000008366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 100340 {ECO:0000313|EMBL:GAB94430.1,
RC ECO:0000313|Proteomes:UP000008366};
RA Yoshida I., Isaki S., Hosoyama A., Tsuchikane K., Katsumata H., Ando Y.,
RA Ohji S., Hamada M., Tamura T., Yamazoe A., Yamazaki S., Fujita N.;
RT "Whole genome shotgun sequence of Kineosphaera limosa NBRC 100340.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB94430.1}.
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DR EMBL; BAHD01000005; GAB94430.1; -; Genomic_DNA.
DR AlphaFoldDB; K6W5I3; -.
DR STRING; 1184609.KILIM_005_00470; -.
DR eggNOG; COG0827; Bacteria.
DR Proteomes; UP000008366; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:GAB94430.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008366};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:GAB94430.1}.
FT DOMAIN 20..215
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT REGION 553..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 575 AA; 61356 MW; 8D60440DD4E7F57A CRC64;
MVGETATVST VEHVDTDALR KARGAFFTPP EVAAYVARWA VRSAADCVLE PSCGEAAFLL
AAHERVQTFP SVGPTRLDGV ELHAASAHVA RAVLRAAGAS ARVRVSDFFA VEPEPSYDAV
IGNPPYMRYQ DFAGADRAAS RRAALRAGVA LTGLASSWAA FTVHSALFLK PGGRLGLVLP
AELLSVNYAA QVREFLMRRF ARVRLVLFTE RVFPGVLEDV VLLLAEGSGG TDHCELLQVQ
DADALAELDP ETAAVWTPTS TSGKWTSALL PTASAAAYAA ATTGAGFSTL HTWGETTLGM
VTGANKFFTL TPAQAARLGL ADDELLPLSP PGSRHLRGLS FTAHMRAELG REGSATLLFR
PPADPSPAAQ AYIQQGEEEG VDAAYKCRVR SPWWRVPLVV PADLLLTYMN ADTPRLTTNT
AGAHHLNSVH GVYLTDEHRV LGRELLPLTS LNSVTLVGAE IVGRAYGGGM LKLEPREADD
LPVPSPAGVL ECADALRAVR PRVRDHLRAG RLLDAVRLVD QVILHDSSAL DAAGISDLEQ
AYAMLAARRR ARGTKAKDRV SPHAMALSRR AQDQA
//
