ID K6WAT7_9ACTN Unreviewed; 1292 AA.
AC K6WAT7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Putative non-ribosomal peptide synthetase {ECO:0000313|EMBL:GAB89287.1};
GN ORFNames=GORHZ_055_00720 {ECO:0000313|EMBL:GAB89287.1};
OS Gordonia rhizosphera NBRC 16068.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1108045 {ECO:0000313|EMBL:GAB89287.1, ECO:0000313|Proteomes:UP000008363};
RN [1] {ECO:0000313|EMBL:GAB89287.1, ECO:0000313|Proteomes:UP000008363}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 16068 {ECO:0000313|EMBL:GAB89287.1,
RC ECO:0000313|Proteomes:UP000008363};
RA Takarada H., Isaki S., Hosoyama A., Tsuchikane K., Katsumata H., Baba S.,
RA Ohji S., Yamazaki S., Fujita N.;
RT "Whole genome shotgun sequence of Gordonia rhizosphera NBRC 16068.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB89287.1}.
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DR EMBL; BAHC01000055; GAB89287.1; -; Genomic_DNA.
DR STRING; 1108045.GORHZ_055_00720; -.
DR eggNOG; COG0110; Bacteria.
DR eggNOG; COG1020; Bacteria.
DR Proteomes; UP000008363; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR012728; NRPS_C.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR NCBIfam; TIGR02353; NRPS_term_dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 3.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008363};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 643..671
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 837..861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 873..900
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1080..1102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1108..1133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 503..577
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 123..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1036..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1292 AA; 137159 MW; 19821E5B626E2D7E CRC64;
MGIPAHFLLS AQASAPRTLC DVLDETTARF PDAPAIDDGE LTLSYTQLLA LIRRGAERLA
AAGVGRGGRV GIRMPSGSRE LYVAILSTLY AGASYVPVDA DDPPERAELV FGEAAVDVVV
DASGIHPTGG DDPAPVATES PDDARPSSGD DAWIIFTSGS TGTPKGVAVT HRNAAAFVDA
EARMFLLDDP LGPGDRVLAG LSVAFDASCE EMWLAWRNGA CLVPAPRSLV RSGMDLGPWL
VQRDINVVST VPTLASLWPA EAMEAVRLLI FGGEACPPEL AERLAVEGRE VWNTYGPTEA
TVVACAAQMD GTGPVRIGLP LPGWDLVVVD GDGNPVGDGE IGELVIGGVG LARYLDPAKD
AEKYAPMPTL GWDRAYRSGD LVKLDHSGLL FQGRADDQVK VGGRRIELGE IDNALQKLPG
VSGAAAAVRK SAAGNSLLVG YLVSPNPDFD VTGAHTELLK HLPAPMVPRL ALVDELPTRT
SGKVDRNALP WPLPSGRTSD EDNDLSDTEV WVARCWTDVL GVVVDDPRAD FFAEGGGSLA
AAQLVTALRE RHPDITVADL YDHPRLGSLA EMLDERVPSV VVTPRDVVPT PRRAGLAQIA
LSVPLTTLTG LQWATWLGVA NNVAAEVVHR ADRDVPWLVE VNWWVLLVAF LLFITPPGRM
LIAATGARLL LMGLRPGTYP RGSGTHIRLW VAERLLDASG AANLSGAPWM IYLARALGAN
IGRGVDLHTI PPVTGFLTVN DGASVEPEVD LAGWWIDGDR VHIGEIMVKR GASIGARSTL
LPGAVIGRDA IVAPGSAVRG RVKSRQLWAG SPAVKVGKAD HPWPDHRPPR GTQWVPVYGL
SSMVLAAIPL ISLAAGLAVM GSWAVHADQL ADVALRCLIL LAPATIASLA VFAAITAILV
RLLSIGLTRG YHPVRSRVGW QVWMTERLLD MARTYLFPLY ASLLTPWWFR LLGVTVGPGT
EISTALVLPK FTTIGEGAFL ADDTMVASYE LGGGWLHVDV AKIGKRSFLG NSGMTAPGRK
VPKDGLVAVL SATPESAKSG SSWLGSPPTR LRRTATETDT SRTFDPPMSL KLARAIVETL
RIIPVMVSFA LGLFMLLGLQ YVAVETSYWV AALVSGVLLL VAGAAACCVA AAAKWIVVGR
IEVSEHPLWS SFVWRNELSD AFVETVAAPW FANAAAGTPI LNLWLRMLGA TIGRGVWCET
YWLPEADLVT LGDGATVQRG CVVQTHLFHD RVMAIDEVTL EAGATLGPHC VALPASGLGE
STTVGPASLV MRGDVVPAHT RWQGNPIAPW HE
//
