ID K6WV10_9ACTN Unreviewed; 1034 AA.
AC K6WV10;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=dnaE {ECO:0000313|EMBL:GAB90374.1};
GN ORFNames=GORHZ_102_00010 {ECO:0000313|EMBL:GAB90374.1};
OS Gordonia rhizosphera NBRC 16068.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1108045 {ECO:0000313|EMBL:GAB90374.1, ECO:0000313|Proteomes:UP000008363};
RN [1] {ECO:0000313|EMBL:GAB90374.1, ECO:0000313|Proteomes:UP000008363}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 16068 {ECO:0000313|EMBL:GAB90374.1,
RC ECO:0000313|Proteomes:UP000008363};
RA Takarada H., Isaki S., Hosoyama A., Tsuchikane K., Katsumata H., Baba S.,
RA Ohji S., Yamazaki S., Fujita N.;
RT "Whole genome shotgun sequence of Gordonia rhizosphera NBRC 16068.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAB90374.1}.
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DR EMBL; BAHC01000102; GAB90374.1; -; Genomic_DNA.
DR RefSeq; WP_006333118.1; NZ_BAHC01000102.1.
DR AlphaFoldDB; K6WV10; -.
DR STRING; 1108045.GORHZ_102_00010; -.
DR eggNOG; COG0587; Bacteria.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000008363; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000008363};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..73
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
FT NON_TER 1034
FT /evidence="ECO:0000313|EMBL:GAB90374.1"
SQ SEQUENCE 1034 AA; 113138 MW; 3BFF0092386FEE78 CRC64;
MTDSFVHLHN HTEYSMLDGA AKVSPLFAEA KRLGMTAIGM TDHGNMFGAS EFYNTAVKND
IKPIIGIEAY IAPASRFDTK RVTWGTRDQK DDDVSGSGAY THMTMVAANA TGLRNLFKLS
SLASIEGQLG KWSRMDVDLI AQYAEGIIAT TGCPSGEVQT RLRLGHEREA LEAAAKWQEI
FGPENFYLEL MEHGLEIERR VRDGLLEIGR TLGIKPIVTN DCHYVTKDHA ASHEALLCVQ
TGKTLSDPTR FKFDGDGYYL KSAEEMRAQW DSVVPGACDN TLGIGERVES YADVFTHRDR
MPIFPVPEGD SQETWLRKEV AAGLARRFPD GAPEEYRRRA EYELGVIIQM GFPAYFLVVG
DLIRHALEVG IRVGPGRGSA AGSLVAWALG ITNIDPIPHG LLFERFLNPE RVSMPDIDID
FDDRRRGEMV RYATERWGSE KVAQVITFGT IKTKAAIKDS ARVQFGQPGF AIADRITKAL
PPPIMAKDIP VSGIMDESHE RYAEASEVRT LIETDPDVKK IFDTALGLEG LIRNAGVHAC
AVIMSSEPLT DAIPVWKRAQ DGAIITGWDY PSCEAIGLLK MDFLGLRNLT VIGDAIENIK
LNRGIDLDLD KLPLEDDKTY ELLARGDTLG VFQLDGGAMR ELLKMMQPTG FEDIVAVLAL
YRPGPMGVNA HTDYAKRKNG LQQIKPIHPE LEEPLKEILA ETYGLIVYQE QIMQIAQKVA
GYSLGQADLL RRAMGKKKKE ILDEAYDGFA EGMRSNGFSQ AAITALWDTV LPFAGYAFNK
SHAAGYGLVS FWTAYLKANF PAEYMAGLLT SVGDDKDKAA IYLADCRKLG ITVLPPDVNE
SQRNFAAVGA DIRFGLAAIR NVGTGVVSSI LAAREEKGKF TTFSDYLGKI DVTACNKKVT
ESLIKAGAFD SLGHPRKGLF LVHGDAVESV IGTKKAEAIG QFDLFGDAGG ADETMAEVFA
VKVPDEEWES KHKLALEREM LGLYVSDHPL AGVAHAIAAQ TDTSITSLLE GSVPDGAQIT
IGGIISSVNR RVNK
//