ID K6WW98_9ALTE Unreviewed; 504 AA.
AC K6WW98;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Tryptophan halogenase, putative {ECO:0000313|EMBL:GAC12724.1};
GN ORFNames=GLIP_0069 {ECO:0000313|EMBL:GAC12724.1};
OS Aliiglaciecola lipolytica E3.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Aliiglaciecola.
OX NCBI_TaxID=1127673 {ECO:0000313|EMBL:GAC12724.1, ECO:0000313|Proteomes:UP000006334};
RN [1] {ECO:0000313|EMBL:GAC12724.1, ECO:0000313|Proteomes:UP000006334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E3 {ECO:0000313|EMBL:GAC12724.1,
RC ECO:0000313|Proteomes:UP000006334};
RX PubMed=25009843;
RA Qin Q.-L., Xie B.-B., Yu Y., Shu Y.-L., Rong J.-C., Zhang Y.-J.,
RA Zhao D.-L., Chen X.-L., Zhang X.-Y., Chen B., Zhou B.-C., Zhang Y.-Z.;
RT "Comparative genomics of the marine bacterial genus Glaciecola reveals the
RT high degree of genomic diversity and genomic characteristic for cold
RT adaptation.";
RL Environ. Microbiol. 16:1642-1653(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAC12724.1}.
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DR EMBL; BAEN01000004; GAC12724.1; -; Genomic_DNA.
DR RefSeq; WP_008842544.1; NZ_BAEN01000004.1.
DR AlphaFoldDB; K6WW98; -.
DR STRING; 1127673.GLIP_0069; -.
DR eggNOG; COG0665; Bacteria.
DR OrthoDB; 7178350at2; -.
DR Proteomes; UP000006334; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000006334}.
FT ACT_SITE 80
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 15..18
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 80
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 334
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 343
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 347
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 504 AA; 57226 MW; 3135E3AFF17AD131 CRC64;
MSPQNPIQKI VIVGGGTAGW MTAAALSNSL LKGVSITLIE SEDIGTVGVG EATIPPIKTF
NNTLGISENE FLKNTHGSFK LGIEFVNWGK LNNRYFHPFG QYGRQFDIVN VHQHWLAAEQ
SGTAHPLDEY CMAWAAAKQR RFSPPQPDPR NVLSTYEYAY HFDAGAYAMF LRKYSEQRNV
KRIEGKIKHS QLNPNSGFVD AVVLDNDQLI KGELFIDCSG FRGLLIEQAL KTGYEDMSEY
LPCNSAWAVP CELKDFTPYT RSTAHTAGWQ WRIPLQHRTG NGHVFSNEFI SEQEALDTLM
QNLDGEPLAD PRLLKFTTGR RKRFWNKNVV AIGLSSGFLE PLESTSIHLI QAGIAKLLAL
FPTTDFDQHV IDEYNRIAIN EFEAIRDFLI LHYKLTERDD SEMWRYCKNM PIPETLESKL
LHFESFGRVI KGEMDLFADA SWLAVYIGQG LRPKQRDPLM SYRNSEGDVW LSKLHQALHQ
AAQQLPSHAD YITKHCRSDI NFMS
//
