ID K6X557_9ACTN Unreviewed; 377 AA.
AC K6X557;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Putative acetyl-CoA acyltransferase {ECO:0000313|EMBL:GAC01227.1};
GN ORFNames=GONAM_23_00480 {ECO:0000313|EMBL:GAC01227.1};
OS Gordonia namibiensis NBRC 108229.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC Gordonia.
OX NCBI_TaxID=1208314 {ECO:0000313|EMBL:GAC01227.1, ECO:0000313|Proteomes:UP000035058};
RN [1] {ECO:0000313|EMBL:GAC01227.1, ECO:0000313|Proteomes:UP000035058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 108229 {ECO:0000313|EMBL:GAC01227.1,
RC ECO:0000313|Proteomes:UP000035058};
RA Isaki-Nakamura S., Hosoyama A., Tsuchikane K., Katsumata H., Baba S.,
RA Yamazaki S., Fujita N.;
RT "Whole genome shotgun sequence of Gordonia namibiensis NBRC 108229.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAC01227.1}.
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DR EMBL; BAHE01000023; GAC01227.1; -; Genomic_DNA.
DR RefSeq; WP_006867397.1; NZ_BAHE01000023.1.
DR AlphaFoldDB; K6X557; -.
DR Proteomes; UP000035058; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:GAC01227.1};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:GAC01227.1}.
FT DOMAIN 5..246
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 254..375
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 333
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 363
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 377 AA; 38840 MW; 25A4CF4DD6A5C2CE CRC64;
MRDAVIVDAV RAPIGRRRGA LSGIHPADLS AHVLEALVER TGLDPAVVDD VVWGCVSQSS
EQAGNIARTA ILAAGWPESV PGTTVTRACG SSQQAVSQAA AAVISGQQDI VIAGGVESMS
RVAMGSSAPN GEHQPATVLD RYGIDKFSQG LGAETIASKW GFDRTRLDEY SLRSHELAAA
AVDRGAFDGQ LAPISGVLEG DEGIRRGGTL ESLGKLKPAF AEDGVIHAGN SSQISDGSGA
LLIMSSETAK SHGLTPIARI HTAVVAADDP VVMLTGPIPS TAKALKRSGL SIDDIGAFEI
NEAFAPVPLA WQAETGADIE RLNPLGGAIA VGHPLGGSGA ILMTRLVHHM RDNGIRYGLQ
SMCEAGGMAN TTILELL
//
