ID   K6XKI1_9ACTN            Unreviewed;       799 AA.
AC   K6XKI1;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Thiolase-like protein type 1 additional C-terminal domain-containing protein {ECO:0000259|Pfam:PF18313};
GN   ORFNames=GONAM_08_01190 {ECO:0000313|EMBL:GAB99329.1};
OS   Gordonia namibiensis NBRC 108229.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC   Gordonia.
OX   NCBI_TaxID=1208314 {ECO:0000313|EMBL:GAB99329.1, ECO:0000313|Proteomes:UP000035058};
RN   [1] {ECO:0000313|EMBL:GAB99329.1, ECO:0000313|Proteomes:UP000035058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 108229 {ECO:0000313|EMBL:GAB99329.1,
RC   ECO:0000313|Proteomes:UP000035058};
RA   Isaki-Nakamura S., Hosoyama A., Tsuchikane K., Katsumata H., Baba S.,
RA   Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia namibiensis NBRC 108229.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Could possibly oxidize fatty acids using specific components.
CC       {ECO:0000256|ARBA:ARBA00002994}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:58856; EC=4.2.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00023709};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
CC         ChEBI:CHEBI:137480; EC=4.2.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00023717};
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|ARBA:ARBA00005254, ECO:0000256|RuleBase:RU003707}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAB99329.1}.
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DR   EMBL; BAHE01000008; GAB99329.1; -; Genomic_DNA.
DR   RefSeq; WP_006865595.1; NZ_BAHE01000008.1.
DR   AlphaFoldDB; K6XKI1; -.
DR   Proteomes; UP000035058; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 2.40.50.840; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR040771; TLP1_add_C.
DR   PANTHER; PTHR11941:SF54; ENOYL-COA HYDRATASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11941; ENOYL-COA HYDRATASE-RELATED; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   Pfam; PF18313; TLP1_add_C; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
FT   DOMAIN          429..515
FT                   /note="Thiolase-like protein type 1 additional C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18313"
FT   REGION          73..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   799 AA;  83336 MW;  D9C5F0F84B92EB17 CRC64;
     MPISIADLDP NTPVVVGVGQ ASERLTDPGY EALGEADLAA RAVTAAFDDA GASDLAYSID
     TIAAIRSFEI SSPLSSSPLG RPDNMPRAVG KRVGADPRRA VQAVTGGQTP QTMLTELAGD
     IAAGDSDAAI IFGAEVMSTV RHLQSKPDNE RPSFAEEVGG QLEDRGYGLK GIITVAEMRH
     GLASVIPQYA LLENARRHNT GLGREAYATA MGELFAPFTK VAAANPHSAA PTERDAAELV
     TPTEGNRIVA DPFTRYIVAR DQVNQAAAVV VMSVRAAQAA GIDPSKWVFL HGHAETVERT
     SLLRSNLGAA PAAPAAVKHA LEVAEIGLDD VSVIDIYSCF PIAVFNILDG LGLSPDDPRG
     LTVTGGLPFF GGPGNNYTLH AIAEVVSRVR QSPGDFGLVI ANGGVLSKHA AGVYSTTPAP
     WRADHSAKIQ AQLDAAPTVP TIGDADGPAI LETYTVIPSK SGKRTGVVVG RLVDDTAPDR
     LGARFVANLD SDDDEFFDLL LNADDPTGTE IVVRSFDKGN RVKLTEAAMN AKYPAVAPAF
     RDSYEHVEIR RDGHLLEVTI NRPDARNALN PAANAELDSI FDAYFADDDL WVAILTGAGD
     KAFSAGNDLA ATASPAALSV PKNGFAGLTA RESLPKPVIA AVNGFALGGG CEIAMACHII
     VADEEASFGL PEVKVGLAAA AGGLVRLPRM IPPALARDMI LTGRRISAAE AAEAGLVSRI
     APAGTVLETA RKVAGEILAA SPTSVRASIA TMEQSDAITD TVEAVRASTN VLDSLIISGD
     TLEGIMAFVM KREPQWKGR
//