ID K6XL58_9ALTE Unreviewed; 718 AA.
AC K6XL58;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=GTP pyrophosphokinase {ECO:0000256|ARBA:ARBA00019852};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
DE AltName: Full=ppGpp synthase I {ECO:0000256|ARBA:ARBA00033308};
GN Name=relA {ECO:0000313|EMBL:GAC21374.1};
GN ORFNames=GARC_4432 {ECO:0000313|EMBL:GAC21374.1};
OS Paraglaciecola arctica BSs20135.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Paraglaciecola.
OX NCBI_TaxID=493475 {ECO:0000313|EMBL:GAC21374.1, ECO:0000313|Proteomes:UP000006327};
RN [1] {ECO:0000313|EMBL:GAC21374.1, ECO:0000313|Proteomes:UP000006327}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BSs20135 {ECO:0000313|EMBL:GAC21374.1,
RC ECO:0000313|Proteomes:UP000006327};
RX PubMed=25009843;
RA Qin Q.-L., Xie B.-B., Yu Y., Shu Y.-L., Rong J.-C., Zhang Y.-J.,
RA Zhao D.-L., Chen X.-L., Zhang X.-Y., Chen B., Zhou B.-C., Zhang Y.-Z.;
RT "Comparative genomics of the marine bacterial genus Glaciecola reveals the
RT high degree of genomic diversity and genomic characteristic for cold
RT adaptation.";
RL Environ. Microbiol. 16:1642-1653(2014).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step
CC 1/2. {ECO:0000256|ARBA:ARBA00004976}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAC21374.1}.
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DR EMBL; BAEO01000062; GAC21374.1; -; Genomic_DNA.
DR RefSeq; WP_007624256.1; NZ_BAEO01000062.1.
DR AlphaFoldDB; K6XL58; -.
DR STRING; 493475.GARC_4432; -.
DR eggNOG; COG0317; Bacteria.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000006327; Unassembled WGS sequence.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF40; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:GAC21374.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006327};
KW Transferase {ECO:0000313|EMBL:GAC21374.1}.
FT DOMAIN 390..451
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 643..718
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 718 AA; 82260 MW; 24E30EB65958CB49 CRC64;
MVSIRTVHED HRPPFDEWLA GLNLPEASKQ KLRDVSDTPE ILLIGQEMVE ILHELHMDDE
TLQAALIYPY CEVHQLDEQQ ITEQFGEGIQ KLIVGVRRMD AIKSLHSRAN SKKKNDEEQI
DNVRRMLLAM VEDVRAVVLK LAERICTLQK VKNEDEETRV LVARECANIY APLANRLGIG
QLKWELEDHS FRYLHPNTYK QIAGLLDERR SDREQYIEDF VEELQEVLDS QNIKAKVYGR
PKHIYSIWKK MQKKHLNFEQ LYDIRAVRII ADRLQDCYAA LGVVHANWKH IRNEFDDYIA
TPKPNGYQSI HTVTLGKQGK TIEIQIRTAK MHEDAELGVA AHWRYKEGTT SSRSAYEERI
NWLRKILLWQ EEVADSGDLV EELRSQVFDD RVYVFTPKGD VVDLPLGSTP LDFAYYIHSN
VGHRCNGAKI AGRIVPFTYQ LQTGDQVEIL TGKHSNPSRD WMHPGLGYVY SSRARAKIQT
YFKKQDKDKN QQAGKELLDR ELVKVNIEPK LASEAIPRFN MQNLDDLYAG IGGGDVRIMQ
VVHYLQQKYA PEPELKIRAK KPQSAKFKKD SIVVEGVGNL LSQIAGCCQP LPGEEIMGYI
TQGRGVSVHR EDCEQLNNLL DQHPERQIDV NWANNLQAAF QTKIQVVGED RDGILRDVTT
VIANEQVTLL GVNSNSDTKL NIAKIELNLE VKNLTYLSKA MSRLNLIKGV TDVFKVDK
//
