ID K6Y2S1_9ALTE Unreviewed; 513 AA.
AC K6Y2S1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:GAC18241.1};
GN ORFNames=GARC_1261 {ECO:0000313|EMBL:GAC18241.1};
OS Paraglaciecola arctica BSs20135.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Paraglaciecola.
OX NCBI_TaxID=493475 {ECO:0000313|EMBL:GAC18241.1, ECO:0000313|Proteomes:UP000006327};
RN [1] {ECO:0000313|EMBL:GAC18241.1, ECO:0000313|Proteomes:UP000006327}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BSs20135 {ECO:0000313|EMBL:GAC18241.1,
RC ECO:0000313|Proteomes:UP000006327};
RX PubMed=25009843;
RA Qin Q.-L., Xie B.-B., Yu Y., Shu Y.-L., Rong J.-C., Zhang Y.-J.,
RA Zhao D.-L., Chen X.-L., Zhang X.-Y., Chen B., Zhou B.-C., Zhang Y.-Z.;
RT "Comparative genomics of the marine bacterial genus Glaciecola reveals the
RT high degree of genomic diversity and genomic characteristic for cold
RT adaptation.";
RL Environ. Microbiol. 16:1642-1653(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAC18241.1}.
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DR EMBL; BAEO01000015; GAC18241.1; -; Genomic_DNA.
DR RefSeq; WP_007617889.1; NZ_BAEO01000015.1.
DR AlphaFoldDB; K6Y2S1; -.
DR STRING; 493475.GARC_1261; -.
DR eggNOG; COG0644; Bacteria.
DR eggNOG; COG0654; Bacteria.
DR OrthoDB; 7178350at2; -.
DR Proteomes; UP000006327; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000006327}.
FT ACT_SITE 79
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 79
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 192
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 339
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 348
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 352
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 513 AA; 58302 MW; 864A2FB1330F156D CRC64;
MQNTLKSICI VGGGTSGWMA ATLLTTALRG SNIQITVIES PDIATIGVGE STVPSMMDFL
QASQINLKEF IQATSATFKL GIRFDDWLTQ GESYFHPFGR VGKDINGFDF YQAWLKSLAD
GQTSRWVDHS PSAIMAEHER FMLRPHQSNQ TQPENWVLSH FAHSLHLDAI QVARYLRDLC
HKRGVTRIEA TVKNVNVDKK DFIRSLELDN GSIVESNFFI DCTGFKGLLI ENSLKVGYQD
WSHYLPCNRA VTVQTENVAN PVPYTIATAR EAGWTWKIPL QHRTGNGYVF SSEHCSDEQA
TETLLNSVNG KLINNPKIIP FVTGKREKIW HNNCLALGLA AGFLEPLEST AIHLVYKTLV
HFIKYFPDMD FDTCNELAFN QKIDVDYTEI RDFIILHYCT SGRDDSDFWR WCQTMPVPDS
LSEKIRLFRQ RGQIEHSTEP FFTSDSWYSI LEGMKIRPQK YHPLLDGFDS QGLANTLHKN
IENIRSTVLK MPSHHDYIQA NCQATHQNAK ATI
//
