ID K6YSU4_9ALTE Unreviewed; 251 AA.
AC K6YSU4;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=tRNA pseudouridine synthase C {ECO:0000256|ARBA:ARBA00040675};
DE EC=5.4.99.26 {ECO:0000256|ARBA:ARBA00038943};
DE AltName: Full=tRNA pseudouridine(65) synthase {ECO:0000256|ARBA:ARBA00041975};
DE AltName: Full=tRNA pseudouridylate synthase C {ECO:0000256|ARBA:ARBA00043049};
DE AltName: Full=tRNA-uridine isomerase C {ECO:0000256|ARBA:ARBA00041803};
GN Name=truC {ECO:0000313|EMBL:GAC14350.1};
GN ORFNames=GLIP_1717 {ECO:0000313|EMBL:GAC14350.1};
OS Aliiglaciecola lipolytica E3.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Alteromonadaceae; Aliiglaciecola.
OX NCBI_TaxID=1127673 {ECO:0000313|EMBL:GAC14350.1, ECO:0000313|Proteomes:UP000006334};
RN [1] {ECO:0000313|EMBL:GAC14350.1, ECO:0000313|Proteomes:UP000006334}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E3 {ECO:0000313|EMBL:GAC14350.1,
RC ECO:0000313|Proteomes:UP000006334};
RX PubMed=25009843;
RA Qin Q.-L., Xie B.-B., Yu Y., Shu Y.-L., Rong J.-C., Zhang Y.-J.,
RA Zhao D.-L., Chen X.-L., Zhang X.-Y., Chen B., Zhou B.-C., Zhang Y.-Z.;
RT "Comparative genomics of the marine bacterial genus Glaciecola reveals the
RT high degree of genomic diversity and genomic characteristic for cold
RT adaptation.";
RL Environ. Microbiol. 16:1642-1653(2014).
CC -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-65 in
CC transfer RNAs. {ECO:0000256|ARBA:ARBA00037670}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=uridine(65) in tRNA = pseudouridine(65) in tRNA;
CC Xref=Rhea:RHEA:42536, Rhea:RHEA-COMP:10103, Rhea:RHEA-COMP:10104,
CC ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.26;
CC Evidence={ECO:0000256|ARBA:ARBA00036607};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAC14350.1}.
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DR EMBL; BAEN01000036; GAC14350.1; -; Genomic_DNA.
DR RefSeq; WP_008844166.1; NZ_BAEN01000036.1.
DR AlphaFoldDB; K6YSU4; -.
DR STRING; 1127673.GLIP_1717; -.
DR eggNOG; COG0564; Bacteria.
DR OrthoDB; 9785808at2; -.
DR Proteomes; UP000006334; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0106029; F:tRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd02563; PseudoU_synth_TruC; 1.
DR Gene3D; 3.30.2350.10; Pseudouridine synthase; 1.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006224; PsdUridine_synth_RluA-like_CS.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR PANTHER; PTHR21600; MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE; 1.
DR PANTHER; PTHR21600:SF56; TRNA PSEUDOURIDINE SYNTHASE C; 1.
DR Pfam; PF00849; PseudoU_synth_2; 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS01129; PSI_RLU; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:GAC14350.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006334};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 12..171
FT /note="Pseudouridine synthase RsuA/RluA-like"
FT /evidence="ECO:0000259|Pfam:PF00849"
SQ SEQUENCE 251 AA; 28709 MW; 6EE4355AC13799FF CRC64;
MHLDILYQDE YIVAVDKPAG LLVHRSMIDR HETQFAMQLL RDQLGQHVFP VHRLDKPTSG
VLLFALSSEI AKTLNQQFAD KHVSKTYFAI VRGYSPEAGQ IDYPLKEKLD KIADKKAQQD
KPAQDAVTDY QCLQQFELPF AVGRYQTSRF SLVKLQPLTG RKHQLRRHMA HIRHPILGDT
THGDGKQNAF LRHQFNLQGL ALSCSEMVIS HPVTQLRLKL AAQFDIRLAV LLEQWGLSLK
QIQNLTNLNN D
//
