ID K6ZUP1_PANTR Unreviewed; 539 AA.
AC K6ZUP1; A0A2J8PTW8;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Discoidin, CUB and LCCL domain containing 1 {ECO:0000313|EMBL:JAA08831.1, ECO:0000313|Ensembl:ENSPTRP00000085062.1};
GN Name=DCBLD1 {ECO:0000313|EMBL:JAA08831.1,
GN ECO:0000313|Ensembl:ENSPTRP00000085062.1, ECO:0000313|VGNC:VGNC:7173};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA08831.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000085062.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA08831.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA08831.1}, Skin
RC {ECO:0000313|EMBL:JAA30441.1}, and Smooth vascular
RC {ECO:0000313|EMBL:JAA21550.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000085062.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; AACZ04054354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01002507; JAA08831.1; -; mRNA.
DR EMBL; GABF01000595; JAA21550.1; -; mRNA.
DR EMBL; GABD01002659; JAA30441.1; -; mRNA.
DR Ensembl; ENSPTRT00000098373.1; ENSPTRP00000085062.1; ENSPTRG00000018545.7.
DR VGNC; VGNC:7173; DCBLD1.
DR GeneTree; ENSGT00940000157334; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000018545; Expressed in fibroblast and 19 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00057; FA58C; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.170.130.20; LCCL-like domain; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR004043; LCCL.
DR InterPro; IPR036609; LCCL_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46806:SF1; DISCOIDIN, CUB AND LCCL DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF03815; LCCL; 1.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00603; LCCL; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF69848; LCCL domain; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50820; LCCL; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..539
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015095771"
FT TRANSMEM 459..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..150
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 152..248
FT /note="LCCL"
FT /evidence="ECO:0000259|PROSITE:PS50820"
FT DOMAIN 248..412
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT REGION 278..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 41..68
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 539 AA; 59137 MW; 929D4BD29EE0AA4C CRC64;
MVPGARGGGA LARAAGPGLL ALLLAVSAPL RLQAEELGDG CGHLVTYQDS GTMTSKNYPG
TYPNHTVCEK TITVPKGKRL ILRLGDLDIE SQTCASDYLL FTSSSDQYGP YCGSMTVPKE
LLLNTSEVTV RFESGSHISG RGFLLTYASS DHPDLITCLE RASHYLKTEY SKFCPAGCRD
VAGDISGNMV DGYRDTSLLC KAAIHAGIIA DELGGQISVL QRKGISRYEG ILANGVLSRD
GSLSDKRFLF TSNGCSRSLS FEPDGQIRAS SSWQSVNESG DQVHWSPGQA RLQDQGPSWA
SGDSSNNHKP REWLEIDLGE KKKITGIRTT GSTQSNFNFY VKSFVMNFKN NNSKWKTYKG
IVNNEEKVFQ GNSNFRDPVQ NNFIPPIVAR YVRVVPQTWH QRIALKVELI GCQITQGNDS
LVWRKTSQST SVSTKKEDET ITRPIPSEET STGINITTVA IPLVLLVVLV FAGMGIFAAF
RKKKKKGSPY GSAEAQKTDC WKQIKYPFAR HQSAEFTISY DNEKEMTQKL DLITSDMAG
//
