ID K6ZZD0_PANTR Unreviewed; 343 AA.
AC K6ZZD0; A0A2J8PX33;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Ion channel TACAN {ECO:0000256|ARBA:ARBA00039635};
DE AltName: Full=Transmembrane protein 120A {ECO:0000256|ARBA:ARBA00041456};
GN Name=TMEM120A {ECO:0000313|EMBL:JAA00598.1,
GN ECO:0000313|Ensembl:ENSPTRP00000085941.1};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA00598.1};
RN [1] {ECO:0000313|Ensembl:ENSPTRP00000085941.1, ECO:0000313|Proteomes:UP000002277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16136131; DOI=10.1038/nature04072;
RG Chimpanzee sequencing and analysis consortium;
RT "Initial sequence of the chimpanzee genome and comparison with the human
RT genome.";
RL Nature 437:69-87(2005).
RN [2] {ECO:0000313|EMBL:JAA00598.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA00598.1}, and Skin
RC {ECO:0000313|EMBL:JAA24244.1};
RA Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT "De novo assembly of the reference chimpanzee transcriptome from NextGen
RT mRNA sequences.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSPTRP00000085941.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus inner membrane
CC {ECO:0000256|ARBA:ARBA00004473}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004473}.
CC -!- SIMILARITY: Belongs to the TMEM120 family.
CC {ECO:0000256|ARBA:ARBA00009700}.
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DR EMBL; AC182767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GABC01010740; JAA00598.1; -; mRNA.
DR EMBL; GABD01008856; JAA24244.1; -; mRNA.
DR RefSeq; XP_001156903.2; XM_001156903.4.
DR RefSeq; XP_016801326.1; XM_016945837.1.
DR STRING; 9598.ENSPTRP00000081243; -.
DR Ensembl; ENSPTRT00000084367.1; ENSPTRP00000085941.1; ENSPTRG00000048556.1.
DR Ensembl; ENSPTRT00000090615.1; ENSPTRP00000088097.1; ENSPTRG00000044557.1.
DR GeneID; 747412; -.
DR CTD; 83862; -.
DR GeneTree; ENSGT00390000007848; -.
DR OrthoDB; 314124at2759; -.
DR Proteomes; UP000002277; Unplaced.
DR Bgee; ENSPTRG00000044557; Expressed in liver and 15 other cell types or tissues.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR012926; TACAN/TMEM120B.
DR PANTHER; PTHR21433:SF1; ION CHANNEL TACAN; 1.
DR PANTHER; PTHR21433; TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA; 1.
DR Pfam; PF07851; TMPIT; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 343 AA; 40629 MW; 5EFE24181BCB6959 CRC64;
MQPPPPGPLG DCLRDWEDLQ QDFQNIQETH RLYRLKLEEL TKLQNNCTSS ITRQKKRLQE
LALALKKCKP SLPAEAEGAA QELENQMKER QGLFFDMEAY LPKKNGLYLS LVLGNVNVTL
LSKQAKFAYK DEYEKFKLYL TIILILISFT CRFLLNSRVT DAAFNFLLVW YYCTLTIRES
ILINNGSRIK GWWVFHHYVS TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY
QSGCLYRLRA LGERHTMDLT VEGFQSWMWR GLTFLLPFLF FGHFWQLFNA LTLFNLARDP
QCKEWQVLMC GFPFLLLFLG NFFTTLRVVH QKFHSQRHGS KKD
//
